Titre : | Evaluation of an injection depot formulation of buprenorphine: placebo comparison |
Titre traduit : | (Evaluation d'un implant sous-cutanée de buprénorphine, comparativement à un placebo.) |
Auteurs : | S. C. SIGMON ; C. J. WONG ; CHAUSMER A. L. ; I. A. LIEBSON ; G. E. BIGELOW |
Type de document : | Périodique |
Année de publication : | 2004 |
Format : | 1439-1449 / fig. ; tabl. |
Note générale : |
Addiction, 2004, 99, (11), 1439-1449 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés BUPRENORPHINE ; VOIE SOUSCUTANEE ; EFFICACITE ; SYNDROME DE SEVRAGE |
Résumé : |
FRANÇAIS : Chez15 usagers dépendant des opioïdes on a pratiqué soit un implant de buprénorphine 58 mg soit un placebo. La buprénorphine sous cutanée a supprimé les symptômes de sevrage et a eu des effets agonistes opioïdes. ENGLISH : Aims: Buprenorphine is a mu-opioid partial agonist that is marketed in a sublingual formulation as a treatment for opioid dependence. A microcapsule depot sustained-release formulation has been developed which may offer effective treatment of opioid dependence while also minimizing risks of illicit diversion or patient non-compliance. The present study examined the efficacy of depot buprenorphine in suppressing the opioid withdrawal syndrome and in attenuating the effects of exogenous opioid challenge. Design: A placebo-controlled, double-blind, randomized trial. Setting: A closed residential research facility. Participants: A total of 15 opioid-dependent participants were enrolled into the 6-week study. Intervention: Fifteen participants were randomized to receive a single subcutaneous depot injection containing buprenorphine (58 mg) or placebo. Two participants, both of whom received placebo, terminated participation after depot administration. Thirteen participants (six buprenorphine, seven placebo) completed the 6-week study and were assessed throughout the study for signs and symptoms of opioid withdrawal and for response to weekly subcutaneous challenges with 3 mg hydromorphone. Measurement: Subjective, physiological and observer-rated indices of opioid withdrawal and opioid agonist effects. Findings: Depot buprenorphine provided more effective relief from opioid withdrawal than placebo, as evidenced by significantly fewer buprenorphine participants requiring supplemental medications for withdrawal suppression after depot administration compared to participants receiving placebo. In the weekly hydromorphone challenge sessions, depot buprenorphine significantly reduced opioid response on measures of subjective effects and pupillary diameter. Conclusions: Results from this double-blind, placebo-controlled study indicate that depot buprenorphine is effective in providing both withdrawal suppression and opioid blockade. Future studies examining additional doses and repeated dosing regimens with depot buprenorphine are warranted. (Author' s abstract) |
Note de contenu : | fig. ; tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 41 |
Affiliation : |
5510 Nathan Shock Drive, Baltimore, MD 21234 Etats-Unis. United States. |
Numéro Toxibase : | 208003 |
Centre Emetteur : | 02 Coordonnateur |
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