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Cardiorespiratory function in stable methadone maintenance treatment (MMT) patients
(Fonction cardio-respiratoire chez des patients stabilisés en traitement de maintenance à la méthadone.)
Auteur(s) :
H. TEICHTAHL ;
D. WANG ;
CUNNINGTON D. ;
I. KRONBORG ;
C. GOODMAN ;
A. PRODROMIDIS ;
O. H. DRUMMER
Article en page(s) :
247-253
Refs biblio. :
38
Domaine :
Plusieurs produits / Several products
Langue(s) :
Anglais
Discipline :
PAT (Pathologie organique / Organic pathology)
Thésaurus mots-clés
PATHOLOGIE ORGANIQUE
;
APPAREIL CARDIOVASCULAIRE
;
APPAREIL RESPIRATOIRE
;
TABAC
;
CANNABIS
;
TRAITEMENT DE MAINTENANCE
;
PREVALENCE
Note générale :
Addiction Biology, 2004, 9, (3-4), 247-253
Résumé :
Patients in methadone maintenance programmes (MMT) often smoke tobacco and cannabis and many have ongoing illicit drug use. There is therefore potential for these patients to have abnormal cardiorespiratory function; however, few studies address this in stable MMT patients. We assessed resting cardiorespiratory function on 50 stable MMT patients (25 males, 25 females). Forty-six MMT patients were current tobacco smokers, 19 were current cannabis users and none were currently using opioids other than prescribed methadone. We defined abnormalities of respiratory function as those results outside the 95% confidence interval of reference values for normal subjects adjusted for age, weight, height and sex. Thirty-one (62%) MMT patients had reduced carbon monoxide transfer factor (DLCO); 17 (34%) had elevated single breath alveolar volume (VA) and 43 (86%) had a reduced DLCO/VA ratio. Six patients (12%) had reduced FEV1; one (2%) had reduced FVC; and nine (18%) had an obstructive ventilatory defect. Ten (20%) patients had PaCO2 higher than 45 mmHg and 14 (28%) had alveolar to arterial oxygen gradient (A-aPO2) higher than 15 mmHg. CXR, Echocardiography and ECG showed no significant abnormalities. We conclude that stable MMT patients have abnormalities of resting respiratory function which may be due to ongoing tobacco cigarette and current or past cannabis smoking. (Author' s abstract)
Affiliation :
Dprt of Respiratory and Sleep Disorders Medicine, Western Hospital, Footscray, 3011, Victoria.
Australie. Australia.
Australie. Australia.
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