Titre : | A randomised, controlled trial of low dose naltrexone for the treatment of opioid dependence |
Titre traduit : | (Essai contrôlé randomisé d'administration de faibles doses de naltrexone pour le traitement de la dépendance aux opiacés) |
Auteurs : | REA F. ; J. R. BELL ; M. R. YOUNG ; R. P. MATTICK |
Type de document : | Périodique |
Année de publication : | 2004 |
Format : | 79-88 / fig. ; graph. ; tabl. |
Note générale : |
Drug and Alcohol Dependence, 2004, 75, (1), 79-88 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés NALTREXONE ; HEROINE ; DEPENDANCE ; PHARMACOTHERAPIE ; PREVENTION ; RECHUTE |
Résumé : |
ENGLISH : Aim: To investigate the efficacy of low doses of naltrexone in relapse prevention for heroin dependence. Design: Double blind, randomised comparison of three groups-Group 1 taking 50 mg per day, Group 2: 0.5 mg per day, and Group 3: 0.05 mg per day. Participants: Sixty-six dependent heroin users. Interventions: After detoxification followed by 1 week on 50 mg per day naltrexone, participants were randomised to trial medication. All were offered counselling and monitored with weekly clinical reviews. Research interviews were conducted at three and 6 months. Outcome measures: Retention in treatment and heroin use at 3 and 6 months. Secondary outcome measures were side effects and craving. Findings: Mean days retained in randomised treatment were-Group 1: 58.9 days; Group 2: 46.6 days; and Group 3: 47.8 days. Differences in retention were not significant using survival analysis. However, nine of the first 60 participants, transferred to the 50 mg dose, and one transferred to a lower dose (chi-square = 0.142; P = 0.018). At follow-up, there was no relationship between abstinence from heroin and naltrexone dose, nor between level of heroin use and dose. There were no differences between groups in craving or depression. Conclusion: Low doses of naltrexone had no discernible advantage, and participants preferred 50 mg per day. Despite preference for blocking doses of naltrexone, outcomes appeared to be independent of naltrexone dose. (Review's abstract.) |
Note de contenu : | fig. ; graph. ; tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 20 |
Affiliation : |
The Langton Ctr., South Eastern Sydney Area Health Serv., 591 South Dowling St., Surry Hills, Sydney, NSW 2010 Australie. Australia. |
Numéro Toxibase : | 804641 |
Centre Emetteur : | 08 CAS Strasbourg |
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