| Titre : | A pilot trial of topiramate for the treatment of cocaine dependence |
| Titre traduit : | (Essai contrôlé d'utilisation du topiramate pour le traitement de la dépendance à la cocaïne) |
| Auteurs : | K. M. KAMPMAN ; PETTINATI H. ; K. G. LYNCH ; C. DACKIS ; T. SPARKMAN ; WEIGLEY C. ; C. P. O'BRIEN |
| Type de document : | Périodique |
| Année de publication : | 2004 |
| Format : | 233-240 / graph. ; tabl. |
| Note générale : |
Drug and Alcohol Dependence, 2004, 75, (3), 233-240 |
| Langues: | Anglais |
| Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
| Mots-clés : |
Thésaurus mots-clés COCAINE ; DEPENDANCE ; MECANISME D'ACTION ; NEUROTRANSMETTEURS ; ANTICONVULSIVANTS ; ESSAI THERAPEUTIQUE |
| Résumé : |
ENGLISH : Background: Both GABAergic and glutamatergic neurons appear to be important modulators of the brain reward system and medications that affect GABA and glutamatergic neurotransmission may reduce the rewarding properties of cocaine and reduce cocaine craving. Topiramate, an anticonvulsant, raises cerebral GABA levels, facilitates GABAergic neurotransmission and inhibits glutametergic activity at AMPA/kainite receptors. Thus, it may be useful for treating cocaine dependence. Methods: The efficacy of topiramate for cocaine dependence was tested in a 13-week, double-blind, placebo-controlled pilot trial (n = 40). Topiramate was titrated gradually over 8 weeks to a dose of 200 mg daily. The primary outcome measure was cocaine abstinence verified by twice weekly urine benzoylecgonine tests (UBT). Results: Eighty-two percent of subjects completed the trial. Analysis of the UBT using a GEE model showed that after week 8, when the dose titration was completed, topiramate-treated subjects were more likely to be abstinent from cocaine compared to placebo-treated subjects (Z = 2.67, P = 0.01). Topiramate-treated subjects were also more likely to attain 3 weeks of continuous abstinence from cocaine (X2 = 3.9, d.f. = 1, P = 0.05). Conclusion: Topiramate may be effective for the treatment of cocaine dependence. (Review's abstract.) |
| Note de contenu : | graph. ; tabl. |
| Domaine : | Drogues illicites / Illicit drugs |
| Refs biblio. : | 46 |
| Affiliation : |
Dept. Psychiatry, Univ. PA Sch. Med., 3900 Chestnut Str., Philadelphia, PA 19104 Etats-Unis. United States. |
| Numéro Toxibase : | 804652 |
| Centre Emetteur : | 08 CAS Strasbourg |
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