Titre : | Chronic opiate treatment enhances both cocaine-reinforced and cocaine-seeking behaviors following opiate withdrawal |
Titre traduit : | (Un traitement chronique par les opiacés amplifie les comportements de craving et les comportements renforcés par la cocaïne qui font suite à un sevrage d'opiacés) |
Auteurs : | S. HE ; GRASING K. |
Type de document : | Périodique |
Année de publication : | 2004 |
Format : | 215-221 / fig. ; tabl. |
Note générale : |
Drug and Alcohol Dependence, 2004, 75, (2), 215-221 |
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés COCAINE ; OPIACES ; CONDITIONNEMENT ; AUTOADMINISTRATION ; MODELE ANIMAL ; SYNDROME DE SEVRAGE ; INTERACTION CHIMIQUE |
Résumé : |
ENGLISH : After chronic exposure to psychostimulants or opiates, self-administration or conditioned place preference with either class is increased (sensitized). Cross-sensitization of conditioned place preference, i.e., enhancement of psychostimulant-induced preferences after exposure to opiates, has also been described, but increases in cocaine self-administration after morphine pretreatment have not been reported. The present study evaluated effects of chronic morphine treatment on cocaine reinforcement. Opiate dependence was established in Wistar rats by administration of morphine as a constant infusion that was gradually increased to a dose of 50mg/kg per day over a 1-week period. Immediately after discontinuation of chronic morphine treatment, animals were allowed to acquire cocaine self administration under a simple fixed-ratio schedule (FR-1), and were subsequently advanced to a progressive ratio schedule. Acquisition of cocaine self-administration under the FR-1 did not differ in saline- and morphine-pretreated animals. For cocaine self-administration under a progressive ratio schedule measured at 5 or more days after the onset of opiate withdrawal, chronic pretreatment with morphine increased the number of ratios completed, augmented final response requirements, and produced a more stable pattern of cocaine self-administration. Responding was also increased in morphine-pretreated animals during an initial extinction session. These results show that chronic opiate treatment can enhance both cocaine-reinforced and cocaine-seeking behaviors following opiate withdrawal. A similar effect may occur in human patients who discontinue methadone or other forms of replacement therapy for opiate abuse, and may contribute to relapse involving use of cocaine or other psychostimulants. (Review's abstract.) |
Note de contenu : | fig. ; tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 45 |
Affiliation : |
Dept. Veterans Affairs Med. Ctr., 4801 Linwood Blvd, Kansas City, MO 64128 Etats-Unis. United States. |
Numéro Toxibase : | 804651 |
Centre Emetteur : | 08 CAS Strasbourg |
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