Titre : | Cocaine addicts with conduct disorder are typified by decreased cortisol responsivity and high plasma levels of DHEA-S (2004) |
Titre traduit : | (Les addictions à la cocaïne avec troubles du comportement sont caractéristiques d'une diminution du cortisol et d'un haut niveau de DHEA dans le plasma) |
Auteurs : | BUYDENS-BRANCHEY L. ; BRANCHEY M. |
Type de document : | Article : Périodique |
Dans : | Neuropsychobiology (Vol.50, n°2, July 2004) |
Article en page(s) : | 161-166 |
Langues: | Anglais |
Mots-clés : |
Thésaurus mots-clés DEPENDANCE ; COCAINE ; TROUBLES DU COMPORTEMENT ; BIOLOGIE ; COMORBIDITE ; HORMONES |
Résumé : | There is evidence that children with antisocial behaviors have increased plasma levels of the adrenal androgen dehydroepiandrosterone sulfate (DHEA-S) and either a decreased level of another adrenal steroid, cortisol, or a decreased cortisol responsivity to stress. Low levels of cortisol have also been reported in antisocial adults but their levels of DHEA-S have not been studied. The present study was designed to perform in adult cocaine addicts simultaneous assessments of DHEA-S and cortisol as a function of a diagnosis of antisocial personality disorder (adult symptoms) and of a retrospective diagnosis of conduct disorder (CD). Basal cortisol and DHEA-S were determined in the plasma samples of 40 hospitalized men. The patients' cortisol responsivity was also assessed while they were being exposed to a stressful situation. Patients who had a retrospective CD diagnosis had significantly increased DHEA-S levels and secreted less cortisol when stressed. Comparisons between patients who did and did not meet the antisocial personality disorder adult criteria did not reveal any significant difference in DHEA-S or in cortisol responsivity. This could be attributed to the nature of the criteria used to define the adult disorder, which focus mostly on a failure to conform to social norms, whereas a number of CD criteria involve displays of some degree of violence. In conclusion, adults who retrospectively qualified for a CD diagnosis had increased DHEA-S levels and a decreased cortisol reactivity, confirming observations made in children and indicating that mechanisms underlying adrenal steroid alterations in childhood could still be at play in adulthood. (Author' s abstract) |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 38 |
Affiliation : |
New York Harbor Healthcare System, Brooklyn Campus, Brooklyn, N.Y. Etats-Unis. United States. |
Numéro Toxibase : | 207844 |
Centre Emetteur : | 02 Coordonnateur |
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