Titre : | Drug therapy: Gamma-hydroxybutyric acid (2005) |
Auteurs : | SNED O. C. ; K. M. GIBSON |
Type de document : | Article : Périodique |
Dans : | New England Journal of Medicine (Vol.352, n°26, June 30, 2005) |
Article en page(s) : | 2721-2732 |
Note générale : | p. 2671-2: Close calls with club drugs [Perspective], McGinn C.G. |
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés GHB ; PHARMACOLOGIE ; NEUROBIOLOGIE ; NEUROTRANSMETTEURS ; USAGE THERAPEUTIQUE ; POTENTIEL ADDICTIF ; MECANISME D'ACTION |
Résumé : | The short-chain fatty acid gamma-hydoxybutyric (GHB) was synthesized in 1960 in an attempt to create an analogue of the ubiquitous inhibitory brain neurotransmitter gamma-aminobutyric acid (GABA) that would cross the blood-brain barrier. GHB turned out to have sedative properties similar to those that had been reported for g-butyrolactone 13 years earlier. In fact, g-butyrolactone has since been shown to be biologically inactive, since all its biologic and behavioral effects are due to its rapid conversion to GHB by an active lactonase. Although GHB has found limited clinical use as an anesthetic agent and in the treatment of narcolepsy and alcoholism, widespread interest has developed during the past 5 to 10 years because GHB has emerged as a major recreational drug and public health problem in the United States. GHB has diverse neuropharmacologic and neurobiologic properties and appears to have dual neuronal mechanisms ofaction that include activation ofboth the g-aminobutyric acid type B (GABAb) receptor and a separate, GHB-specific receptor. This complex interaction between GHB and the GHB and GABAb receptors within mesocorticolimbic dopamine pathways is probably responsible for the addictive nature of GHB and for symptoms of withdrawal from it. (Author' s abstract) |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 104 |
Affiliation : | Department of Pediatrics, University of Toronto, Canada |
Numéro Toxibase : | 208372 |
Centre Emetteur : | 02 Coordonnateur |
Cote : | Abonnement |
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