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Neurobiochemical and clinical aspects of craving in alcohol addiction : a review
(Addiction à l'alcool : aspects neurobiochimiques et cliniques du besoin impérieux de consommer. Une synthèse)
Auteur(s) :
G. ADDOLORATO ;
L. LEGGIO ;
L. ABENAVOLI ;
G. GASBARRINI
Article en page(s) :
1209-1224
Refs biblio. :
80
Domaine :
Alcool / Alcohol
Langue(s) :
Anglais
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
ALCOOL
;
ADDICTION
;
COMPULSION
;
ETIOLOGIE
;
NEUROBIOLOGIE
;
RECHUTE
;
NEUROTRANSMETTEURS
;
COGNITION
;
COMPORTEMENT
;
FACTEUR DE VULNERABILITE
Note générale :
Addictive Behaviors, 2005, 30, (6), 1209-1224
Résumé :
ENGLISH :
Craving plays an important role in the pathogenesis of alcohol dependence and relapse. In this review we have tried to analyse how many contrasting theories have been formulated in order to clarify the concept of craving. Many complex neurobiochemical mechanisms are implicated in the etiology of craving; these mechanisms involve several neurotransmitters, such us dopamine, opioids, glutamate, and serotonin. On the other hand comportamental and/or cognitive aspects could also play a role in the etiology of craving. The coexistence of many and often contrasting theories can indicate that different subtypes of patients could have different mechanisms at the basis of alcohol craving, suggesting that it could be advisable to personalize the anti-craving therapy. (Editor's abstract.)
ENGLISH :
Craving plays an important role in the pathogenesis of alcohol dependence and relapse. In this review we have tried to analyse how many contrasting theories have been formulated in order to clarify the concept of craving. Many complex neurobiochemical mechanisms are implicated in the etiology of craving; these mechanisms involve several neurotransmitters, such us dopamine, opioids, glutamate, and serotonin. On the other hand comportamental and/or cognitive aspects could also play a role in the etiology of craving. The coexistence of many and often contrasting theories can indicate that different subtypes of patients could have different mechanisms at the basis of alcohol craving, suggesting that it could be advisable to personalize the anti-craving therapy. (Editor's abstract.)
Affiliation :
Institute of Internal Medicine, Catholic University of Rome, Gemeli Hospital, Largo A. Gemelli 8, 00168 Rome. E-mail : g.addoloratorm.unicatt.it
Italie. Italy.
Italie. Italy.
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