Titre : | Illicit drug use and abuse/dependence: modeling of two-stage variables using the CCC approach |
Titre traduit : | (Usage et abus/dépendance de drogues illicites : une comparaison des variables influençant ces deux étapes de la consommation à partir de l'approche CCC, qui différentie les facteurs Causals, Communs et Contingents) |
Auteurs : | A. AGRAWAL ; M. C. NEALE ; K. C. JACOBSON ; C. A. PRESCOTT ; K. S. KENDLER |
Type de document : | Périodique |
Année de publication : | 2005 |
Format : | 1043-1048 / tabl. |
Note générale : |
Addictive Behaviors, 2005, 30, (5), 1043-1048 |
Langues: | Anglais |
Discipline : | EPI (Epidémiologie / Epidemiology) |
Mots-clés : |
Thésaurus mots-clés EPIDEMIOLOGIE ; CONSOMMATION ; ABUS ; DEPENDANCE ; TYPE D'USAGE ; COMPARAISON ; ETIOLOGIE ; EVALUATION ; GENETIQUE ; MODELE ; SEXE |
Résumé : |
ENGLISH : Drug use and abuse/dependence are stages of a complex drug habit. Most genetically informative: models that are tit to twin data examine drug use and abuse/dependence independent of each other. This poses an interesting question: for a multistage process, how can we partition the factors influencing each stage specifically from the factors that are common to both stages? We used a causal-common-contingent (CCC) model to partition the common and specific influences on drug use and abuse/dependence. Data on use and abuse/dependence of cannabis, cocaine, sedatives. stimulants and any illicit drug was obtained from male and female twin pairs. CCC models were tested individually for each sex and in a sex-equal model. Our results suggest that there is evidence for additive genetic, shared environmental and unique environmental influences that are common to illicit drug use and abuse/dependence. Furthermore, we found substantial evidence for factors that were specific to abuse/dependence. Finally, sexes could be equated for all illicit drugs. The findings of this study emphasize the need for models that can partition the sources of individual differences into common and stage-specific influences. (Editor's abstract.) |
Note de contenu : | tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 12 |
Affiliation : |
Department of Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Box 980003 Suite 1-154, Richmond, VA 23298-0003. E-mail : arpana_vipbgyahoo.com Etats-Unis. United States. |
Numéro Toxibase : | 404938 |
Centre Emetteur : | 04 CIRDD-51 |
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