Titre : | A double-blind, double-dummy, randomized, prospective pilot study of the partiel Mu opiate agonist, buprenorphine, for acute detoxification from heroin |
Titre traduit : | (Etude pilote prospective randomisée en double aveugle d'utilisation de la buprénorphine, agoniste partiel des récepteurs mu des opiacés, pour le sevrage d'héroïne) |
Auteurs : | ORESKOVICH M. R. ; A. J. SAXON ; M. L. K. ELLIS ; MALTE C. A. ; REOUX J. P. ; P. C. KNOX |
Type de document : | Périodique |
Année de publication : | 2005 |
Format : | 71-79 / graph. ; tabl. |
Note générale : |
Drug and Alcohol Dependence, 2005, 77, (1), 71-79 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés HEROINE ; BUPRENORPHINE ; OPIACES ; DEPENDANCE ; SEVRAGE ; CLONIDINE ; TRAITEMENT DE MAINTENANCE |
Résumé : |
ENGLISH : The optimum dose of buprenorphine for acute inpatient heroin detoxification has not been determined. This randomized, double-blind, double-dummy, pilot study compares two buprenorphine sublingual tablet dosing schedules to oral clonidine. Heroin users (N = 30) who met DSM-IV criteria for opioid dependence and achieved a Clinical Opiate Withdrawal Scale (COWS) score of 13 (moderate withdrawal), were randomized to receive higher dose buprenorphine (HD, 8-8-8-4-2 mg/day on days 15), lower dose buprenorphine (LD, 2-4-8-4-2 mg/day on days 15), or clonidine (C, 0.2-0.3-0.3-0.2-0.1 mg QID on days 15). COWS scores were obtained QID. Twenty-four hours after randomization, the percentages of subjects who achieved suppression of withdrawal, as defined by four consecutive COWS scores |
Note de contenu : | graph. ; tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 37 |
Affiliation : |
Dept. Psychiatr. Behav. Sci., Univ. Washington Sch. Med., 1660 South Columbian Way, Seattle, WA 98108 Etats-Unis. United States. |
Numéro Toxibase : | 804773 |
Centre Emetteur : | 08 CAS Strasbourg |
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