Historique
Périodique
Therapy of the neonatal abstinence syndrome with tincture of opium or morphine drops
(Traitement du syndrome de sevrage néonatal à la teinture d'opium ou avec de la morphine en gouttes)
Auteur(s) :
LANGENFELD, S. ;
BIRKENFELD, L. ;
HERKENRATH P. ;
MULLER, C. ;
HELLMICH M. ;
THEISOHN M.
Année :
2005
Page(s) :
31-36
Langue(s) :
Anglais
Refs biblio. :
22
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
OPIUM
;
MORPHINE
;
OPIACES
;
SYNDROME DE SEVRAGE
;
NOUVEAU-NE
;
ENFANT D'USAGER
;
TRAITEMENT
Note générale :
Drug and Alcohol Dependence, 2005, 77, (1), 31-36
Note de contenu :
tabl. ; graph.
Résumé :
ENGLISH :
Background: Treating opioid-addicted women with methadone in pregnancy increased the number of newborns suffering from neonatal abstinence syndrome (NAS). High-pitch crying, insomnia, tremor, myoclonic jerks, vomiting, diarrhoea and poor weight gain were reported symptoms, which were evaluated using the Finnegan (F)-score. Earlier phenobarbital or paregoric had been used to suppress symptoms. We surveyed the administration of pure u-agonist morphine (MO) in comparison to the alcoholic opioid mixture in tincture of opium (TO). Thirty-three newborns were included in the survey, after informed consent by their parents. Results: NAS started 35 days after delivery and lasted for 27 or 30 days (mean) in the TO and MO groups, respectively. In either of the tested parameters, we found no significant differences between the two groups (2P
Affiliation :
Dept. Pharmacol., Univ. Cologne, Gleuelerstr.24, Cologne 50931. E-mail: martin.theisohnmedizin.uni-koeln.de
Allemagne. Germany.
Allemagne. Germany.