Titre : | Altered brain tissue composition in heavy marijuana users |
Titre traduit : | (Altération de la composition du tissu nerveux chez les gros fumeurs de marijuana) |
Auteurs : | MATOCHIK J. A. ; ELDRETH D. A. ; J. L. CADET ; BOLLA K.I. |
Type de document : | Périodique |
Année de publication : | 2005 |
Format : | 23-30 / tabl. ; ill. |
Note générale : |
Drug and Alcohol Dependence, 2005, 77, (1), 23-30 |
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés CANNABIS ; CERVEAU ; MECANISME D'ACTION ; IMAGERIE MEDICALE ; TOXICITE |
Résumé : |
ENGLISH : Marijuana is the most widely used illicit substance in the United States; however, previous imaging studies have not detected altered brain structure in marijuana users compared to non-users. Voxel-based morphometry was used to investigate possible differences in brain tissue composition in a group of 11 heavy marijuana users and a group of 8 non-users. All participants were male. Statistical comparisons were made at the voxel level on T1-weighted magnetic resonance images to determine differences in gray matter and white matter tissue density. Compared to non-users, marijuana users had lower gray matter density in a cluster of voxels in the right parahippocampal gyrus (P = 0.0001), and greater density bilaterally near the precentral gyrus and the right thalamus (P |
Note de contenu : | tabl. ; ill. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 39 |
Affiliation : |
NIH/DHHS, 5500 N. Shock Drive, Baltimore, MD 21224-6823. E-mail: jmatochiintra.nida.nih.gov Etats-Unis. United States. |
Numéro Toxibase : | 804769 |
Centre Emetteur : | 08 CAS Strasbourg |
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