Historique
Périodique
Altered brain tissue composition in heavy marijuana users
(Altération de la composition du tissu nerveux chez les gros fumeurs de marijuana)
Auteur(s) :
MATOCHIK J. A. ;
ELDRETH D. A. ;
CADET, J. L. ;
BOLLA K.I.
Année :
2005
Page(s) :
23-30
Langue(s) :
Anglais
Refs biblio. :
39
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
Drug and Alcohol Dependence, 2005, 77, (1), 23-30
Note de contenu :
tabl. ; ill.
Résumé :
ENGLISH :
Marijuana is the most widely used illicit substance in the United States; however, previous imaging studies have not detected altered brain structure in marijuana users compared to non-users. Voxel-based morphometry was used to investigate possible differences in brain tissue composition in a group of 11 heavy marijuana users and a group of 8 non-users. All participants were male. Statistical comparisons were made at the voxel level on T1-weighted magnetic resonance images to determine differences in gray matter and white matter tissue density. Compared to non-users, marijuana users had lower gray matter density in a cluster of voxels in the right parahippocampal gyrus (P = 0.0001), and greater density bilaterally near the precentral gyrus and the right thalamus (P
Affiliation :
NIH/DHHS, 5500 N. Shock Drive, Baltimore, MD 21224-6823. E-mail: jmatochiintra.nida.nih.gov
Etats-Unis. United States.
Etats-Unis. United States.