Titre : | HCV viremia is associated with drug use in young HIV-I and HCV coinfected pregnant and non-pregnant women |
Titre traduit : | (La virémie VHC est associée à l'usage de drogue chez de jeunes femmes, enceintes ou pas, coinfectées par le VIH 1 et le VHC) |
Auteurs : | NIKOLOPOULOU G. B. ; NOWICKI M. J. ; DU W. ; HOMANS J. ; STEK A. ; F. KRAMER ; A. KOVACS |
Type de document : | Périodique |
Année de publication : | 2005 |
Format : | 626-635 / tabl. |
Note générale : |
Addiction, 2005, 100, (5), 626-635 |
Langues: | Anglais |
Discipline : | MAL (Maladies infectieuses / Infectious diseases) |
Mots-clés : |
Thésaurus mots-clés HEPATITE ; VIRUS ; SEXE FEMININ ; GROSSESSE ; VIH ; ETUDE TRANSVERSALE ; INJECTION ; CONTAMINATION ; FACTEUR DE RISQUE |
Résumé : |
ENGLISH : Aims : Vertical transmission of HCV is increased among HIV-1/HCV coinfected women and is related to HCV viral load. In this study we assessed clinical and demographic factors associated with HCV viremia in a cohort of young pregnant and non-pregnant mothers coinfected with HIV-1. Design : A cross-sectional clinic-based study nested within a prospective cohort study. Methods : From 1988 to 2000, HIV-1 + pregnant and non-pregnant women with children followed in a large maternal, child and adolescent HIV-1 clinic were evaluated for HCV infection using EIA 3.0. HCV RNA levels were determined for HCV antibody + women using polymerase chain reaction. Demographic and clinical characteristics between HCV-RNA(+) and HCV-RNA({PRIVATE "TYPE=PICT;ALT=-"}) women and between pregnant and non-pregnant HIV-1/HCV coinfected women were compared using univariate and multivariate analyses. Findings : Among 359 HIV-1(+) women, 84 (23%) were HCV-ab + and 49/84 (58%) had detectable HCV-RNA in plasma. Median age was 31. CD4 counts, HIV-1 RNA levels and demographic characteristics were similar for viremic and non-viremic women and pregnant and non-pregnant women. However, viremic women were more likely to report a history of (88% versus 43% ; P |
Note de contenu : | tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 55 |
Affiliation : |
Maternal, Child and Ado. Ctr. for Infect. Dis. and Virology LAC & USC Med. Ctr., Univ. Sth Calif., Keck Sch. Med., 1640 Marengo St., HRA Build., 3th floor, L. A. , CA 90033 ; akovacs@usc.edu Etats-Unis. United States. |
Numéro Toxibase : | 208235 |
Centre Emetteur : | 02 Coordonnateur |
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