Titre : | General anaesthesia does not improve outcome in opioid antagonist detoxification treatment: a randomized controlled trial |
Titre traduit : | (L'anesthésie générale n'améliore pas les résultats d'une désintoxication par antagoniste opioïdes : un essai controllé randomisé.) |
Auteurs : | C. A. J. DE JONG ; R. J. F. LAHEIJ ; P. F. M. KRABBE |
Type de document : | Périodique |
Année de publication : | 2005 |
Format : | 206-215 / fig. ; tabl. |
Note générale : |
Addiction, 2005, 100, (2), 206-215
|
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés CURE DE DESINTOXICATION ; DESINTOXICATION ; OPIOIDES ; ANESTHESIE ; EFFICACITE ; COUT ; COMPARAISONThésaurus géographique PAYS-BAS |
Résumé : | Aim. Opioid detoxification by administering opioid-antagonists under general anaesthesia has caused considerable controversy. This study is conducted to determine whether rapid detoxification under general anaesthesia results in higher levels of opioid abstinence than rapid detoxification without anaesthesia. Design. Randomized controlled open clinical trial from September 1999 to August 2001. Setting. Four addiction centres in collaboration with three general hospitals in the Netherlands. Participants. A total of 272 opioid-dependent patients whose previous attempts to abstain were unsuccessful. Intervention. Patients received rapid detoxification with general anaesthesia (RD-GA) or without general anaesthesia (RD). Measurements. Urine screens and an interview (EuropASI) to assess opioid abstinence; two questionnaires (SOOS, OOWS) to measure withdrawal symptoms and one to measure craving (VAS). Findings. One month after the intervention 62.8% of the patients in the RD-GA group and 60.0% in the RD group were abstinent for opioids (P = 0.71). No adverse events or complications occurred during RD; however, in the RD-GA group, five adverse events necessitated admission to a general hospital. The average 1-month cost for RD was 2517 euros versus 4439 euros for RD-GA. Conclusions. Rapid detoxification under general anaesthesia did not result in higher levels of opioid abstinence than rapid detoxification without anaesthesia. The cost of the former intervention was much higher. (Author' s abstract) |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 35 |
Affiliation : |
Kentron Network for Addiction Treatment Services, Nijmegen Institute for Scientist-Practitioners in Addiction, Radboud University Nijmegen, PO Box 9104, 6500 HE Nijmegen, Pays-Bas. Netherlands. |
Numéro Toxibase : | 208194 |
Centre Emetteur : | 02 Coordonnateur |
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