| Titre : | A medication screening trial evaluation of reserpine, gabapentin and lamotrigine pharmacotherapy of cocaine dependence |
| Titre traduit : | (Evaluation de l'essai thérapeutique de reserpine, gabapentin et lamotrigine dans la pharmacothérapie de la dépendance à la cocaïne) |
| Auteurs : | S. P. BERGER ; T. M. WINHUSEN ; SOMOZA E. C. ; J. M. HARRER ; MEZINSKIS J. P. ; LEIDERMAN D. B. ; M. A. MONTGOMERY ; R. J. GOLDSMITH ; D. A. BLOCH ; SINGAL B. M. ; A. ELKASHEF |
| Type de document : | Périodique |
| Année de publication : | 2005 |
| Format : | 58-67 / graph. ; tabl. |
| Note générale : |
Addiction, 2005, 100, (Suppl. 1 Clinical Rapid Efficacy Screening Trials (CREST)), 58-67 |
| Langues: | Anglais |
| Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
| Mots-clés : |
Thésaurus TOXIBASE COCAINE ; DEPENDANCE ; PHARMACOTHERAPIE ; MEDICAMENTS ; ESSAI THERAPEUTIQUE ; PLACEBO |
| Résumé : |
ENGLISH : Aims : To conduct a preliminary evaluation of the safety and efficacy of reserpine, gabapentin or lamotrigine versus an unmatched placebo control as a treatment for cocaine dependence. Design : A 10-week out-patient study using the Cocaine Rapid Efficacy and Safety Trial (CREST) study design. Setting : The study was conducted at the Cincinnati Medication Development Research Unit (MDRU). Participants : Participants met Diagnostic and Statistical Manual version IV (DSM-IV) criteria for cocaine dependence. Sixty participants were enrolled, with 50 participants completing the final study measures. Intervention : The targeted daily doses of medication were reserpine 0.5 mg, gabapentin 1800 mg and lamotrigine 150 mg. All participants received 1 hour of manualized individual cognitive behavioral therapy on a weekly basis. Measurements : Primary outcome measures of efficacy included urine benzoylecgonine (BE) level, Cocaine Clinical Global Impression scale{PRIVATE "TYPE=PICT;ALT=-"}observer and self-report of cocaine use. Safety measures included adverse events, electrocardiograms (ECGs), vital signs and laboratory tests. Findings : Subjective measures of cocaine dependence indicated significant improvement for all study groups. Urine BE results indicated a significant improvement for the reserpine group (P |
| Note de contenu : | graph. ; tabl. |
| Domaine : | Drogues illicites / Illicit drugs |
| Sous-type de document : | N° spécial de revue / Special issue of a journal |
| Refs biblio. : | 33 |
| Affiliation : |
Psychiatry Service Department of Veterans Affairs Medical Center Mental Health (P3MHDC) 3710 SW US Veterans Hospital Road Portland OR 97201 ; bergerp@ohsu.edu Etats-Unis. United States. |
| Numéro Toxibase : | 208108 |
| Centre Emetteur : | 02 Coordonnateur |
Exemplaires
| Disponibilité |
|---|
| aucun exemplaire |
Accueil
