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A medication screening trial evaluation of reserpine, gabapentin and lamotrigine pharmacotherapy of cocaine dependence
(Evaluation de l'essai thérapeutique de reserpine, gabapentin et lamotrigine dans la pharmacothérapie de la dépendance à la cocaïne)
Auteur(s) :
BERGER, S. P. ;
WINHUSEN, T. M. ;
SOMOZA E. C. ;
HARRER, J. M. ;
MEZINSKIS J. P. ;
LEIDERMAN D. B. ;
MONTGOMERY, M. A. ;
GOLDSMITH, R. J. ;
BLOCH, D. A. ;
SINGAL B. M. ;
ELKASHEF, A.
Année :
2005
Page(s) :
58-67
Sous-type de document :
N° spécial de revue / Special issue of a journal
Langue(s) :
Anglais
Refs biblio. :
33
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
COCAINE
;
DEPENDANCE
;
PHARMACOTHERAPIE
;
MEDICAMENTS
;
ESSAI THERAPEUTIQUE
;
PLACEBO
Note générale :
Addiction, 2005, 100, (Suppl. 1 Clinical Rapid Efficacy Screening Trials (CREST)), 58-67
Note de contenu :
graph. ; tabl.
Résumé :
ENGLISH :
Aims : To conduct a preliminary evaluation of the safety and efficacy of reserpine, gabapentin or lamotrigine versus an unmatched placebo control as a treatment for cocaine dependence. Design : A 10-week out-patient study using the Cocaine Rapid Efficacy and Safety Trial (CREST) study design. Setting : The study was conducted at the Cincinnati Medication Development Research Unit (MDRU). Participants : Participants met Diagnostic and Statistical Manual version IV (DSM-IV) criteria for cocaine dependence. Sixty participants were enrolled, with 50 participants completing the final study measures. Intervention : The targeted daily doses of medication were reserpine 0.5 mg, gabapentin 1800 mg and lamotrigine 150 mg. All participants received 1 hour of manualized individual cognitive behavioral therapy on a weekly basis. Measurements : Primary outcome measures of efficacy included urine benzoylecgonine (BE) level, Cocaine Clinical Global Impression scale{PRIVATE "TYPE=PICT;ALT=-"}observer and self-report of cocaine use. Safety measures included adverse events, electrocardiograms (ECGs), vital signs and laboratory tests. Findings : Subjective measures of cocaine dependence indicated significant improvement for all study groups. Urine BE results indicated a significant improvement for the reserpine group (P
Affiliation :
Psychiatry Service Department of Veterans Affairs Medical Center Mental Health (P3MHDC) 3710 SW US Veterans Hospital Road Portland OR 97201 ; bergerp@ohsu.edu
Etats-Unis. United States.
Etats-Unis. United States.