Titre : | A controlled trial of methylphenidate in adults with attention deficit/hyperactivity disorder and substance use disorders |
Titre traduit : | (Un essai contrôlé d'administration de méthylphénidate chez des adultes, usagers de drogues, présentant des troubles d'hyperactivité avec déficit d'attention.) |
Auteurs : | P. J. CARPENTIER ; C. A. J. DE JONG ; B. A. G. DIJKSTRA ; C. A. G. VERBRUGGE ; P. F. M. KRABBE |
Type de document : | Périodique |
Année de publication : | 2005 |
Format : | 1868-1874 / graph. ; tabl. |
Note générale : |
Addiction, 2005, 100, (12), 1868-1874, graph. ; tabl.
|
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés COMORBIDITE ; TROUBLES DU COMPORTEMENT ; TROUBLES DE L'ATTENTION ; METHYLPHENIDATE ; EFFICACITE |
Résumé : | Aims: Attention delicit/hyperactivity disorder (ADHD) is common among adult patients with substance use disorders. The benefits of treating ADHD in these patients are uncertain and the prescription of psychostimulants is disputed, because of the risk of abuse. This study examined the short-term effectiveness of methylphenidate treatment for ADHD in adults with substance use disorders. Design: Double-blind, placebo-controlled, multiple cross-over (A-B-A-B design) comparative trial of methylphenidate versus placebo. Setting: ln-patient addiction treatment facility. Participants: Twenty-five patients with ADHD who were receiving in-patient treatment for various substance use disorders. Intervention During the course of 8 weeks, each participant completed two phases of placebo and two phases of active medication treatment, in a fixed low-dosage schedule (up to 0.6 mg/kg/day). Abstinence was maintained during the study. Measurements: The outcome measure was ADHD symptomatology, as measured with the ADHD rating scale-IV The results were compared using MANOVA repeated measures. Findings Nineteen of the 2 5 patients completed the trial. A significant reduction in ADHD symptoms was observed in the first week in both conditions. The positive response to active treatment (nine patients: 36%) was not significantly higher than that to placebo (five patients; 20%). Conclusions: In this small pilot study, the effect of low-dose methylphenidate in adult ADHD patients with concomitant substance use disorders is limited. ADHD symptoms in adults were susceptible to a distinct short-term placebo response. (Author' s abstract) |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 27 |
Affiliation : |
Novadic-Kentron, Schijndelseweg 46, 5491 TB Sint-Oedenrode. Pays-Bas. Netherlands. |
Numéro Toxibase : | 208624 |
Centre Emetteur : | 02 Coordonnateur |
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