Titre : | Long-term effects of MDMA (Ecstasy) on the human central nervous system revealed by visual evoked potentials |
Titre traduit : | (Effets à long terme de l'ecstasy sur le système nerveux central chez l'homme mis en évidence à l'aide des potentiels visuels évoqués.) |
Auteurs : | CASCO C ; FORCELLA M. C. ; G. BERETTA ; GRIECO A. ; CAMPANA G. |
Type de document : | Périodique |
Année de publication : | 2005 |
Format : | 187-195 |
Note générale : | Addiction Biology, 2005, 10, (2), 187-195 |
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés MDMA-ECSTASY ; PHYSIOLOGIE ; NEUROLOGIE ; EFFET SECONDAIRE ; SYSTEME NERVEUX CENTRAL ; COGNITION |
Résumé : | Several studies indicate long-term cognitive impairment of MDMA (ecstasy) users. In the present study we attempted to establish whether electrophysiological correlates of low-level cognitive processes present a long-term alteration, dependent on the level of use of ecstasy. We addressed this issue by investigating amplitude and latency of VEPs related to a very simple discrimination task involving sustained attention (arousal). Eight heavy-MDMA users, eight moderate-MDMA users and 18 drug-free control subjects were asked to discriminate whether the digit at the centre of the screen was 1 or 2. None of the subjects (except one) had used MDMA in the 6 months previous testing. We measured psychophysical performance and EEG, recorded in Oz and Fz during task execution. The heavy-MDMA users made significantly more errors than the other two groups (p |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 64 |
Affiliation : | Dipart. Psicologia Generale, Univ. di Padova, Italy |
Numéro Toxibase : | 208845 |
Centre Emetteur : | 02 Coordonnateur |
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