Titre : | Polymorphism in the serotonin transporter gene and response to treatment in African-American cocaine and alcohol-abusing individuals |
Titre traduit : | (Polymorphisme du gène transporteur de la sérotonine et réponse au traitement chez des personnes abusant de cocaïne et d'alcool, d'origine afro-américaine.) |
Auteurs : | P. MANNELLI ; A. A. PATKAR ; H. W. MURRAY ; CERTA K. ; PEINDL K. ; M. MATTILA-EVENDEN ; W. H. BERRETTINI |
Type de document : | Périodique |
Année de publication : | 2005 |
Format : | 261-268 / graph. ; tabl. |
Note générale : |
Addiction Biology, 2005, 10, (3), 261-268 |
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés COCAINE ; ALCOOL ; TRAITEMENT ; SEROTONINE ; GENETIQUE ; FACTEUR DE RISQUE |
Résumé : |
ENGLISH : The serotonin transporter (5-HTT) regulates serotonin transmission and modulates behavioral effects of drug of abuse. A polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) yielding a short (S) and long (L) allele has been associated with severity of substance abuse. The aims of the study were to investigate whether 5-HTTLPR genotypes differed in their response to treatment in cocaine- and alcohol-abusing patients. Polymerase chain reaction-based genotyping of a 44 base pair insertion/deletion polymorphism was performed in 141 African American cocaine-dependent patients with concurrent alcohol use who were entering a 12-week behaviorally oriented outpatient treatment program. In treatment, end of treatment and 6-month follow-up outcome measures included changes in Addiction Severity Index (ASI) scores, urine drug screens, days in treatment, individual/group sessions, dropout and completion rates. As expected, there was a reduction in substance abuse by the end of treatment and follow-up (F = 5.15, p = 0. 000). However, there were no differences in the reduction in cocaine use across the LL, LS and SS genotypes. Interestingly, individuals with the S allele showed greater severity of alcohol use at admission (F= 4.84, p = 0. 03), and the SS genotype showed less improvement in alcohol measures than the LL at follow-up (F = 3. 68, p = 0. 03), after controlling for baseline variables. While we found no association of the 5-HTTLPR variants with severity of cocaine abuse or any cocaine-related outcome measures, the data suggested that the S-HTTLPR polymorphism may distinguish responders from non-responders to behavioral treatment in terms of alcohol use. Further investigations are required to determine the role of the 5-HTTLPR polymorphism in influencing treatment-outcome among substance abusers. (Author' s abstract) |
Note de contenu : | graph. ; tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 57 |
Affiliation : |
Associate Professor of Psychiatry Duke University Medical Center, 4323 Ben Franklin Blvd, Suite 700, Durham, NC 27704. Email : ashwin.patkarkuke.edu Etats-Unis. United States. |
Numéro Toxibase : | 208468 |
Centre Emetteur : | 02 Coordonnateur |
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