Titre : | Acute phase and five-year follow-up study of fluoxetine in adolescents with major depresssion and a comorbid substance use disorder: a review |
Titre traduit : | (Usage de fluoxétine en phase de crise et étude de suivi sur 5 ans chez des adolescents souffrant d'une grave dépression et d'une comorbidité de troubles liés à l'usage de substances psychoactives : une revue) |
Auteurs : | J. R. CORNELIUS ; D. B. CLARK ; O. G. BUKSTEIN ; B. BIRMAHER ; SALLOUM I. M. ; S. A. BROWN |
Type de document : | Périodique |
Année de publication : | 2005 |
Format : | 1824-1833 |
Note générale : |
Addictive Behaviors, 2005, 30, (9), 1824-1833 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés COMORBIDITE ; DEPRESSION ; ADOLESCENT ; ANTIDEPRESSEURS ; SUIVI DU PATIENT ; ETUDE LONGITUDINALE |
Résumé : |
ENGLISH : This paper reviews the results of an acute phase trial and a five-year follow-up study fluoxetine in adolescent with major depression and a substance use disorder (SUD). This study included a 12-week open label acute phase study of 13 comorbid adolescents. followed by comprehensive assessments conducted 1, 3, and 5 years after entry into an acute phase fluoxetine trial. The results of the acute phase study and of the 1, 3, and 5-year follow-up assessments have already been published in four papers. The current paper was designed to cover the results of the study across the entire 5-year time spectrum of the study, and to summarize the clinical results across that entire time period. The data from this pilot study suggest that the long-term (5-year) clinical course for the Alcohol Dependence, Cannabis Dependence, and academic functioning of comorbid adolescents following acute phase treatment with SSRIs is generally good. However, the long-term clinical course for the Major Depression of that comorbid adolescent population is surprisingly poor. (Editor's abstract.) |
Domaine : | Plusieurs produits / Several products |
Refs biblio. : | 29 |
Affiliation : |
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, PAARC Suite, Pittsburgh, PA 15213. E-mail : jcornelpitt.edu Etats-Unis. United States. |
Numéro Toxibase : | 405116 |
Centre Emetteur : | 04 CIRDD-51 |
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