Titre : | Nefazodone in out-patient treatment of inhaled cocaine dependence: a randomized double-blind placebo-controlled trial |
Titre traduit : | (La néfazodone dans le traitement ambulatoire de la dépendance à la cocaïne inhalée : un essai randomisé, contre placébo, en double aveugle.) |
Auteurs : | S. R. LAMBERT PASSOS ; L. A. BASTOS CAMACHO ; C. S. LOPES ; M. A. BORGES DOS SANTOS |
Type de document : | Périodique |
Année de publication : | 2005 |
Format : | 489-494 / tabl. |
Note générale : |
Addiction, 2005, 100, (4), 489-494, tabl.
|
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés COCAINE ; TRAITEMENT ; ANTIDEPRESSEURS ; EFFICACITE |
Résumé : |
FRANÇAIS :
La comparaison des résultats entre les 2 groupes ne démontre pas l'indication de cet antidépresseur dans la dépendance à la cocaïne. ENGLISH: Aims To assess the efficacy of oral nefazodone in the treatment of cocaine dependence. Design A 10-week randomized double-blind clinical trial was performed. Methods All 210 subjects fulfilled Diagnostic and Statistical Manual version IV (DSM-IV) criteria for cocaine dependence and were assigned randomly to 300 mg/day of oral nefazodone (N) or placebo (P). Self-reported drug use, retention interval in treatment, adherence to prescription and depressive symptoms were assessed by the Hamilton scale. Findings Abstinence from cocaine for 3 weeks or more was achieved by 49.5% (N) and 45.7% (P) (P = 0.58), but 16.2% (N) and 22.9% (P) used other drugs during abstinence. The average interval to resumption of drug use was 33.9 days (N) and 36.1 days (P). Adverse effects were reported by 45.8% (N) and 29.5% (P) (P = 0.01). Treatment for these events was needed more often in N (24.0%) than in P (9.5%) (P |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 28 |
Affiliation : |
Instituto de Pesquisa Clínica Evandro Chagas Fundação Oswaldo Cruz, Epidemiology Department, Avenue Brasil 4365, Manguinhos, Rio de Janeiro, Brésil. Brazil. |
Numéro Toxibase : | 208279 |
Centre Emetteur : | 02 Coordonnateur |
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