Titre : | Puffy hand syndrome due to drug addiction: a casecontrol study of the pathogenesis |
Titre traduit : | (Le lymphoedème des mains dû à linjection de drogues : une étude de cas contrôlés des pathogénèses.) |
Auteurs : | V. ANDRESZ ; N. MARCANTONI ; F. BINDER ; M. VELTEN ; M. ALT ; J. C. WEBER ; D. STEPHAN |
Type de document : | Périodique |
Année de publication : | 2006 |
Format : | 1347-1351 / tabl. |
Note générale : |
Addiction, 2006, 101, (9), 1347-1351, tabl.
|
Langues: | Anglais |
Discipline : | PAT (Pathologie organique / Organic pathology) |
Mots-clés : |
Thésaurus mots-clés BUPRENORPHINE ; VOIE INTRAVEINEUSE ; PATHOLOGIE ORGANIQUE ; OEDEME ; MAIN |
Résumé : | Aim: We studied the pathogenesis of puffy hand syndrome of intravenous drug use. We hypothesized that injections of high-dose sublingual buprenorphine, instead of the recommended sublingual administration, could play an important role in lymphatic obstruction and destruction. Design and participants: We set up a casecontrol study in substitution centres, recruiting intravenous drug addicts with and without puffy hands, respectively. The subjects were asked to answer anonymously a questionnaire of 40 items comprising social and demographic status, history of illicit drugs use, buprenorphine misuse and injection practices. Findings: We included 33 cases and 33 controls, mean age of 34 years. They were past heroin users, mainly methadone-substituted. In multivariate analysis, sex (women) (OR = 8.9, P = 0.03), injections in the hands (OR = 5.9, P = 0.03), injections in the feet (OR = 6.5, P = 0.01) and the absence of tourniquet (OR = 7.0, p = 0.02) were significant risk factors for puffy hand syndrome. In 69.7% of the cases and 59.4% of the controls, respectively, there was a high-dose sublingual buprenorphine misuse, although it appeared not to be a significant risk factor for puffy hand syndrome. Conclusions: Injection practices are likely to cause puffy hands syndrome, but buprenorphine misuse should not be considered as a significant risk factor. However, intravenous drug users must still be warned of local and systemic complications of intravenous drug misuse. (Author' s abstract) |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 20 |
Affiliation : |
Service Hypertension Maladies vasculaires Pharmacologie clinique, Hôpitaux Universitaires de Strasbourg, 67091 Strasbourg cedex, France. France. |
Numéro Toxibase : | 208868 |
Centre Emetteur : | 02 Coordonnateur |
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