Titre : | Methadone-associated Torsades de Pointes (polymorphic ventricular tachycardia) in opioid-dependent patients |
Titre traduit : | (Torsades de pointes associées à la méthadone - tachycardie ventriculaire polymorphique - chez des patients dépendants des opioïdes.) |
Auteurs : | D. JUSTO ; A. GAL-OZ ; Y. PARAN ; Y. GOLDIN ; D. ZELTSER |
Type de document : | Périodique |
Année de publication : | 2006 |
Format : | 1333-1338 / tabl. |
Note générale : |
Addiction, 2006, 101, (9), 1333-1338, tabl.
|
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés METHADONE ; PATHOLOGIE ORGANIQUE ; APPAREIL CARDIOVASCULAIRE |
Résumé : | Aims: We reviewed all the publications concerning methadone-associated Torsades de Pointes (TdP) (polymorphic ventricular tachycardia) in opioid-dependent patients in order to characterize the clinical circumstances leading to this serious complication. Methods: Our literature search yielded 14 reports on 40 patients with methadone-associated TdP. We gathered and recorded the risk factors for TdP mentioned in those reports, among other clinical aspects. Results: The most prevalent risk factors for TdP were high-dose methadone (n = 39, 97.5%) and concomitant use of agents that increase serum methadone levels or trigger TdP (n = 22, 55%). HIV infection (n = 16), hypokalaemia (n = 14), female sex (n = 13), liver cirrhosis or renal failure (n = 11) and heart disease (n = 9) were also described. All the patients had at least one and 34 (85%) had two or more risk factors for TdP during methadone treatment. Conclusions: We wish to raise the level of awareness of risk factors for TdP among physicians in heroin-treatment clinics who frequently prescribe methadone. (Author' s abstract) |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 52 |
Affiliation : |
Department of Internal Medicine D, Tel Aviv Sourasky Medical Center, 6 Weitzman Street, Tel Aviv 64239, Israël. Israel. |
Numéro Toxibase : | 208866 |
Centre Emetteur : | 02 Coordonnateur |
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