| Titre : | Acute effects of cocaine in two models of inhibitory control: implications of non-linear dose effects |
| Titre traduit : | (Effets aigus de la cocaïne sur deux modèles de contrôle de linhibition : implications deffets-dose non linéaires.) |
| Auteurs : | M. T. FILLMORE ; C. R. RUSH ; L. HAYS |
| Type de document : | Périodique |
| Année de publication : | 2006 |
| Format : | 1323-1332 / fig. ; tabl. |
| Note générale : |
Addiction, 2006, 101, (9), 1323-1332
|
| Langues: | Anglais |
| Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
| Mots-clés : |
Thésaurus mots-clés COCAINE ; EFFET SECONDAIRE ; INHIBITION ; TROUBLES DU COMPORTEMENT ; TROUBLES DE LA MEMOIRE ; TEST |
| Résumé : | Aims: This study examined doseresponse effects of oral cocaine on the inhibitory control of behavior in adult cocaine users using two different behavioral models of inhibitory control. Design: Adults (n = 12) with a history of cocaine use performed the stop-signal and cue-dependent gono-go task to measure inhibitory control of behavior in response to a range of oral cocaine HCl doses (0, 100, 200 and 300 mg). Findings: Although both tasks showed cocaine-induced facilitation of inhibitory control, doseresponse functions differed depending on the measures. The stop-signal measure revealed a quadratic doseresponse function and the cued gono-go measure showed a more orderly, linear improvement as a function of dose. Conclusions: The evidence suggests a two-phasic doseresponse in which facilitating effects of stimulant drugs on inhibitory control might be limited to a range of intermediate doses, above which improvement is no longer evident and impairing effects could possibly emerge. (Author' s abstract) |
| Domaine : | Drogues illicites / Illicit drugs |
| Refs biblio. : | 14 |
| Affiliation : |
Department of Psychology, University of Kentucky, Lexington, KY. 405060044. Etats-Unis. United States. |
| Numéro Toxibase : | 208865 |
| Centre Emetteur : | 02 Coordonnateur |
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