Titre : | Systemic disease among cases of fatal opioid toxicity |
Titre traduit : | (Troubles systémiques parmi des cas de toxicité fatale liée aux opioïdes.) |
Auteurs : | S. DARKE ; S. KAYE ; J. DUFLOU |
Type de document : | Périodique |
Année de publication : | 2006 |
Format : | 1299-1305 / tabl. |
Note générale : |
Addiction, 2006, 101, (9), 1299-1305, tabl.
|
Langues: | Anglais |
Discipline : | PAT (Pathologie organique / Organic pathology) |
Mots-clés : |
Thésaurus mots-clés OPIOIDES ; TOXICITE ; SURDOSE ; AUTOPSIE ; PATHOLOGIE ORGANIQUE ; APPAREIL RESPIRATOIRE ; APPAREIL CARDIOVASCULAIRE ; REIN ; FOIE |
Résumé : | Aims: To determine levels of systemic disease among cases of death due to opioid toxicity. Design: Analysis of coronial cases. Setting: Sydney, Australia. Cases: A total of 841 cases of death due to opioid toxicity (1 January 199831 December 2002). Findings: Ventricular hypertrophy was present in 5.9% of cases and severe coronary artery atherosclerosis in 5.7%. Severe coronary pathology was more pronounced among older cases. Pre-existing bronchopneumonia was present in 13.2% of cases. Hepatic pathology was the most common type of pathology, and was far more marked among older cases. Cirrhosis was present in 25.3% of those aged > 44 years. Levels of renal pathology were comparatively low, but were related significantly to increasing age. Systemic disease in more than one organ system was present in 24.4% of cases, and was related to increasing age (44% of those aged > 44 years). The only pathology for which gender was an independent predictor among opioid cases was ventricular hypertrophy, more common in males. Conclusions: Systemic disease, most prominently liver disease, is common among fatal opioid toxicity cases, and may be a factor in understanding the dynamics and age demographics of opioid-related death. (Author' s abstract) |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 33 |
Affiliation : |
National Drug and Alcohol Research Centre, University of New South Wales, NSW, 2052, Australie. Australia. |
Numéro Toxibase : | 208862 |
Centre Emetteur : | 02 Coordonnateur |
Exemplaires
Disponibilité |
---|
aucun exemplaire |
Accueil