Titre : | Psychiatric comorbidity and progression in drug use in adult male twins: implications for the design of genetic association studies |
Titre traduit : | (Comorbidité psychiatrique et trajectoire d'usage de la drogue chez des jumeaux mâles adultes : implications pour la conception d'études génétiques) |
Auteurs : | A. A. TODOROV ; M. T. LYNSKEY ; J. D. GRANT ; J. F. SCHERRER ; R. D. TODD ; K. K. BUCHOLZ |
Type de document : | Périodique |
Année de publication : | 2006 |
Format : | 948-961 / tabl. |
Note générale : |
Addictive Behaviors, 2006, 31, (6), 948-961, tabl.
|
Langues: | Anglais |
Discipline : | PSY (Psychopathologie / Psychopathology) |
Mots-clés : |
Thésaurus mots-clés PSYCHIATRIE ; COMORBIDITE ; CONSOMMATION ; TRAJECTOIRE ; FRATRIE ; RECHERCHE ; GENETIQUE |
Résumé : | Psychiatric comorbidity with drug dependence has been widely documented. In the present study, we reanalyze DSM-III-R diagnostic data on middle-aged male twin pairs from the VETR study using latent class methods. We identify four subtypes based on 15 diagnostic categories. We then show that these subtypes are strongly associated with differential rates of transitions in drug use histories, with increased risks in relatives for depression, alcohol, drug and ASPD, as well as with a variety of non-normative and deviant behaviors in youth and in adulthood. We use the result of these analyses to show how the use of a particular drug disorder phenotype for selecting cases could impact final sample composition. (Editor's abstract.) |
Domaine : | Plusieurs produits / Several products |
Refs biblio. : | 66 |
Affiliation : |
Department of Psychiatry, Midwest Alcoholism Research Center, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134 St. Louis, MO 63110-1502. Etats-Unis. United States. |
Numéro Toxibase : | 405145 |
Centre Emetteur : | 04 CIRDD-51 |
Exemplaires
Disponibilité |
---|
aucun exemplaire |
Accueil