Historique
Périodique
Well-being, psychosocial factors, and side-effects among heroin-dependent inpatients after detoxification using buprenorphine versus clonidine
(Comparaison du bien-être, des facteurs psychosociaux et des effets secondaires constatés chez des héroïnomanes ayant suivi un protocole de désintoxication avec buprénorphine ou avec clonidine)
Auteur(s) :
PONIZOVSKY A. M. ;
GRINSHPOON A. ;
MARGOLIS A. ;
COHEN, R. ;
ROSCA P.
Année :
2006
Page(s) :
2002-2013
Langue(s) :
Anglais
Refs biblio. :
57
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
HEROINE
;
DEPENDANCE
;
SEVRAGE
;
COMPARAISON
;
CLONIDINE
;
BUPRENORPHINE
;
EFFICACITE
Note générale :
Addictive Behaviors, 2006, 31, (11), 2002-2013
Note de contenu :
tabl.
Résumé :
ENGLISH :
Previous studies comparing buprenorphine and clonidine provided little information about subjective factors associated with the effective management of opioid withdrawal. This study sought to compare detoxification programs using these medications with regard to side-effects and related distress, general well-being, perceived self-efficacy and social support. A total of 200 treatment-seeking heroin-dependent patients, aged 1850, were randomly assigned to buprenorphine or clonidine inpatient withdrawal treatments over 10 days followed by 11 days of relapse prevention measures. A semi-structured interview and a battery of self-rating scales assessing parameters of the interest were administered to the patients who completed the 10-day detoxification protocol with buprenorphine (n = 90) and clonidine (n = 50). Chi-square statistics and analysis of covariance were performed to examine between-group differences. Compared with patients treated with clonidine, patients who received buprenorphine developed significantly less side-effects and related distress, and had higher senses of well-being, self-efficacy and social support. The findings suggest that buprenorphine is preferable for inpatient detoxification due to its side-effects profile and positive effects on well-being and psychosocial variables. These early benefits of buprenorphine could enable consequent maintenance treatment. (Editor's abstract.)
Affiliation :
Mental Health Services, Ministry of Health, 2 Ben Tabai St., Jerusalem, 93591. E-mail : alexander.ponizovskymoh.health.gov.il
Israël. Israel.
Israël. Israel.