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ANTICORPS |
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Article : Périodique
One pharmacokinetic approach to the treatment of cocaine abuse and toxicity involves the development of compounds that can be safely administered to humans and that accelerate the metabolism of cocaine to inactive components. Catalytic antibodie[...]Périodique
B. M. KINSEY ; T. R. KOSTEN ; F. M. ORSON | 2010Cocaine abuse is an ongoing and serious problem that has led to the growth of a brutal criminal enterprise, particularly in the Americas and Europe. At present, there are no effective pharmacological agents available to treat the addiction by bl[...]Texte legislatif
Cette circulaire rappelle la conduite à tenir vis à vis du dépistage des anti-corps anti-LAV, un dépistage systématique ne devant ni être mis comme conditions d'admission ou comme condition de prise en charge, ni imposé au personnel.Périodique
M. J. HICKS ; B. P. DE ; J. B. ROSENBERG ; J. T. DAVIDSON ; A. Y. MORENO ; K. D. JANDA ; S. WEE ; G. F. KOOB ; N. R. HACKETT ; S. M. KAMINSKY ; S. WORGALL ; M. TOTH ; J. G. MEZEY ; R. G. CRYSTAL | 2011Based on the concept that anticocaine antibodies could prevent inhaled cocaine from reaching its target receptors in the brain, an effective anticocaine vaccine could help reverse cocaine addiction. Leveraging the knowledge that E1−E3− adenoviru[...]Article : Périodique
M. HANEY ; E. W. GUNDERSON ; H. JIANG ; E. D. COLLINS ; R. W. FOLTIN |BACKGROUND. Rates of relapse among cocaine-dependent patients are high, and new treatment approaches are needed. Clinical data demonstrate that a cocaine vaccine (TA-CD) produces selective anticocaine antibodies, yet the impact of these antibodi[...]Périodique
B. A. MARTELL ; F. M. ORSON ; J. POLING ; E. MITCHELL ; R. D. ROSSEN ; T. GARDNER ; T. R. KOSTEN | 2009CONTEXT. Cocaine dependence, which affects 2.5 million Americans annually, has no US Food and Drug Administration–approved pharmacotherapy. OBJECTIVES. To evaluate the immunogenicity, safety, and efficacy of a novel cocaine vaccine to treat coc[...]Article : Périodique
C. PIOCHE ; C. PELAT ; C. LARSEN ; J. C. DESENCLOS ; M. JAUFFRET-ROUSTIDE ; F. LOT ; J. PILLONEL ; C. BROUARD |FRANÇAIS : Introduction - En 2004, la prévalence de l'infection chronique par le virus de l'hépatite C (VHC) en France métropolitaine avait été estimée à 0,53% (IC95%:[0,40-0,70]). L'objectif de ce travail a été d'actualiser l'estimation de la [...]Article : Périodique
PURPOSE OF REVIEW: To describe the rationale of vaccines against cocaine and nicotine, to review progress in developing and trialing vaccines to treat dependence on these drugs and to discuss some of the ethical issues that may arise from their [...]Article : Périodique
A. JUDD ; J. PARRY ; M. HICKMAN ; T. McDONALD ; L. JORDAN ; K. LEWIS ; CONTRERAS M. ; DUSHEIKO G. ; G. FOSTER ; N. GILL ; K. KEMP ; J. MAIN ; I. MURRAY-LYON ; M. NELSON |Oral fluid testing is an effective alternative to serum antibody testing for surveillance of human immunodeficiency virus (HIV) and hepatitis B infections, and is being extended to hepatitis C infections. The objective of this study was to deter[...]Article : Périodique
P. K. NELSON ; B. M. MATHERS ; B. COWIE ; H. HAGAN ; D. C. DES JARLAIS ; D. HORYNIAK ; L. DEGENHARDT |BACKGROUND: Injecting drug use is an important risk factor for transmission of viral hepatitis, but detailed, transparent estimates of the scale of the issue do not exist. We estimated national, regional, and global prevalence and population siz[...]Article : Périodique
P. RYAN ; J. VALENCIA ; G. CUEVAS ; J. TROYA ; C. RAMON ; A. RODRIGUEZ ; J. TORRES-MACHO ; M. J. MUNOZ-GOMEZ ; I. CANOREA ; S. VAZQUEZ-MORON ; S. RESINO |Background: The burden of hepatitis C virus (HCV) infection among people who use drugs (PWUDs) is considerable. We aimed to screen for HCV infection using the fingerstick dried blood spot (DBS) test and to describe the cascade of hepatitis C car[...]Article : Périodique
A resume, with key European results, is given of Willing Anonymous Salivary HIV/Hepatitis C (WASH-C) surveillance studies for estimating HIV and Hepatitis C prevalence among prisoners, and associated risk behaviours. The WASH methodology was acc[...]Périodique
F. M. ORSON ; B. M. KINSEY ; R. A. SINGH ; Y. WU ; T. GARDNER ; T. R. KOSTEN | 2008Conventional substance-abuse treatments have only had limited success for drugs such as cocaine, nicotine, methamphetamine, and phencyclidine. New approaches, including vaccination to block the effects of these drugs on the brain, are in advance[...]