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ETUDE RANDOMISEE |
Documents disponibles dans cette catégorie (226)
Article : Périodique
BACKGROUND: Many adolescents receive mentoring. There is no systematic review if mentoring prevents alcohol and drug use. OBJECTIVES: Assess effectiveness of mentoring to prevent adolescent alcohol/drug use. SEARCH METHODS: Cochrane CENTRAL [...]Article : Périodique
M. P. CARRIERI ; L. MICHEL ; C. LIONS ; J. COHEN ; M. VRAY ; M. MORA ; F. MARCELLIN ; B. SPIRE ; A. MOREL ; P. ROUX ; The Methaville Study Group |Objective: Methadone coverage is poor in many countries due in part to methadone induction being possible only in specialized care (SC). This multicenter pragmatic trial compared the effectiveness of methadone treatment between two induction mod[...]Article : Périodique
R. P. MATTICK ; C. BREEN ; J. KIMBER ; M. DAVOLI |Background: Methadone maintenance was the first widely used opioid replacement therapy to treat heroin dependence, and it remains the best-researched treatment for this problem. Despite the widespread use of methadone in maintenance treatment fo[...]Article : Périodique
A. SCHNEEGANS ; F. BOURGOGNON ; E. ALBUISSON ; R. SCHWAN ; M. ARFA ; L. POLLI ; M. MOULARD ; V. LAPREVOTE ; T. SCHWITZER |FRANÇAIS : Les approches basées sur la pleine conscience ont montré leur efficacité chez les patients atteints de troubles liés à la consommation de substances. La prévention des rechutes basée sur la pleine conscience (MBRP) intègre les pratiq[...]Article : Périodique
G. SMEDSLUND ; R. C. BERG ; K. T. HAMMERSTROM ; A. STEIRO ; K. A. LEIKNES ; H. M. DAHL ; K. KARLSEN |ENGLISH: BACKGROUND: There are 76.3 million people with alcohol use disorders worldwide and 15.3 million with drug use disorders. Motivational interviewing (MI) is a client-centred, semi-directive method for enhancing intrinsic motivation to ch[...]Article : Périodique
H. RIGTER ; C. E. HENDERSON ; I. PELC ; P. TOSSMANN ; O. PHAN ; V. HENDRIKS ; M. SCHAUB |Background: Noticing a lack of evidence-based programmes for treating adolescents heavily using cannabis in Europe, government representatives from Belgium, France, Germany, The Netherlands, and Switzerland decided to have U.S.-developed multidi[...]Article : Périodique
C. WERCH ; M. J. MOORE ; C. C. DICLEMENTE ; R. BLEDSOE ; E. JOBLI |The primary purpose of this study was to test the efficacy of a brief, multi-health behavior intervention integrating physical activity and alcohol use prevention messages for high school-aged adolescents. A total of 604 participants, 335 9th an[...]Périodique
R. Q. SKRABEK ; L. GALLMOVA ; K. ETHANS ; D. PERRY | 2008A randomized, double-blind, placebo-controlled trial was conducted to determine the benefit of nabilone in pain management and quality of life improvement in 40 patients with fibromyalgia. After a baseline assessment, subjects were titrated up o[...]Article : Périodique
N. LINTZERIS ; A. BHARDWAJ ; L. MILLS ; A. DUNLOP ; J. COPELAND ; I. MCGREGOR ; R. BRUNO ; J. GUGUSHEFF ; N. PHUNG ; M. MONTEBELLO ; T. CHAN ; A. KIRBY ; M. HALL ; M. JEFFERIES ; J. LUKSZA ; M. SHANAHAN ; R. KEVIN ; D. ALLSOP ; Agonist Replacement for Cannabis Dependence study group |ENGLISH: Importance: There are no effective medications for treating dependence on cannabis. Objective: To examine the safety and efficacy of nabiximols in the treatment of patients with cannabis dependence. Design, Setting, and Participants:[...]Article : Périodique
H. E. JONES ; K. KALTENBACH ; S. H. HEIL ; S. M. STINE ; M. G. COYLE ; A. M. ARRIA ; K. E. O'GRADY ; P. SELBY ; P. R. MARTIN ; G. FISCHER |Background: Methadone, a full mu-opioid agonist, is the recommended treatment for opioid dependence during pregnancy. However, prenatal exposure to methadone is associated with a neonatal abstinence syndrome (NAS) characterized by central nervou[...]Article : Périodique
N. WALKER ; V. PARAG ; M. VERBIEST ; G. LAKING ; M. LAUGESEN ; C. BULLEN |Background: Combination nicotine replacement therapy shows additive cessation benefits. We aimed to find out the effectiveness of combining nicotine patches with an e-cigarette (with and without nicotine) on six-month smoking abstinence. Method[...]Article : Périodique
L. F. STEAD ; R. PERERA ; C. BULLEN ; D. MANT ; T. LANCASTER |BACKGROUND: The aim of nicotine replacement therapy (NRT) is temporarily to replace much of the nicotine from cigarettes to reduce motivation to smoke and nicotine withdrawal symptoms, thus easing the transition from cigarette smoking to complet[...]Article : Périodique
A. WHITE ; D. KAVANAGH ; H. STALLMAN ; B. KLEIN ; F. KAY-LAMBKIN ; J. PROUDFOOT ; J. DRENNAN ; J. CONNOR ; A. BAKER ; E. HINES ; R. YOUNG |BACKGROUND: There has been a significant increase in the availability of online programs for alcohol problems. A systematic review of the research evidence underpinning these programs is timely. OBJECTIVES: Our objective was to review the effi[...]Article : Périodique
R. P. SCHWARTZ ; S. M. KELLY ; S. G. MITCHELL ; J. GRYCZYNSKI ; K. E. O'GRADY ; D. GANDHI ; Y. OLSEN ; J. H. JAFFE |Background and Aims: Methadone patients who discontinue treatment are at high risk of relapse, yet a substantial proportion discontinue treatment within the first year. We investigated whether a patient-centered approach to methadone treatment i[...]Périodique
R. S. GARFEIN ; E. T. GOLUB ; A. E. GREENBERG ; H. HAGAN ; D. L. HANSON ; S. M. HUDSON ; F. KAPADIA ; M. H. LATKA ; L. J. OUELLET ; D. W. PURCELL ; S. A. STRATHDEE ; H. THIEDE | 2007OBJECTIVES: To evaluate whether a behavioral intervention, which taught peer education skills, could reduce injection and sexual risk behaviors associated with primary HIV and hepatitis C virus infection (HCV) among young injection drug users (I[...]Article : Périodique
Objective: A small body of evidence supports targeting adolescents who are heavy users of cannabis with brief interventions, yet more research is needed to confirm the effectiveness of these studies. We conducted a secondary analysis of our Peer[...]Article : Périodique
Article : Périodique
BACKGROUND: Personality factors are implicated in the vulnerability to adolescent alcohol misuse. This study examined whether providing personality-targeted interventions in early adolescence can delay drinking and binge drinking in high-risk yo[...]Article : Périodique
A. E. PERRY ; M. NEILSON ; M. MARTYN-ST JAMES ; J. M. GLANVILLE ; R. WOODHOUSE ; C. GODFREY ; C. HEWITT |Background: The review represents one in a family of four reviews focusing on a range of different interventions for drug-using offenders. This specific review considers pharmacological interventions aimed at reducing drug use or criminal activi[...]Article : Périodique
A. ARAIN ; J. DE SOUSA ; K. CORTEN ; R. VERRANDO ; H. THIJS ; C. MATHEI ; F. BUNTINX ; G. ROBAEYS |Background: Treatment uptake for hepatitis C virus (HCV) infection remains low in persons who inject drugs (PWID), due to lack of knowledge and low perceived need for treatment. Therefore, we conducted a pilot study to assess the influence on kn[...]Article : Périodique
ENGLISH : Aims: To assess the feasibility of conducting an RCT comparing buprenorphine and methadone maintenance therapy in Norfolk. Design: Forty-two opiate dependent patients were given the option of being randomized or choosing between open[...]Article : Périodique
AIMS This study conducted a secondary analysis to examine injection cessation and decreasing frequency of injection during a multi-site randomized controlled HIV prevention intervention trial that sought to reduce sexual and injection risk behav[...]Article : Périodique
Young adults in college have high rates of marijuana use, abuse, and dependence. Web-based interventions are increasingly popular, but their dissemination exceeds empirical support. One popular but understudied program is The Marijuana eCHECKUP [...]Article : Périodique
BACKGROUND AND AIMS: The prevalence of cannabis use based on self-reports is likely to be underestimated in population surveys, especially in contexts where its use is a criminal offence. Indirect survey methods ask sensitive questions ensuring [...]Article : Périodique
There are many mandated school-based programs to prevent adolescent alcohol and drug (AOD) use, but few are voluntary and take place outside of class time. Objectives: This cluster randomized controlled trial evaluates CHOICE, a voluntary after[...]Article : Périodique
H. F. BYRNES ; B. A. MILLER ; B. BOURDEAU ; M. B. JOHNSON ; D. B. BULLER ; J. BERTELETTI ; V. A. ROGERS |Objective: Electronic music dance events (EMDEs) at nightclubs attract young adults engaging in high-risk alcohol and other drug (AOD) use. Studies show that most patrons arrive at clubs in groups and that these peer groups influence drinking. T[...]Article : Périodique
H. F. BYRNES ; B. A. MILLER ; J. W. GRUBE ; B. BOURDEAU ; D. B. BULLER ; M. WANG-SCHWEIG ; W. G. WOODALL |This study examines effects of a randomized controlled trial for an online, family-based prevention program for older teens, Smart Choices 4 Teens, on alcohol use and related outcomes. Families (N = 411; teen age M = 16.4, SD = 0.5) were randoml[...]Article : Périodique
A. A. MOORE ; F. C. BLOW ; M. HOFFING ; S. WELGREEN ; J. W. DAVIS ; J. C. LIN ; K. D. RAMIREZ ; D. H. LIAO ; L. TANG ; R. GOULD ; M. GILL ; O. CHEN ; K. L. BARRY |AIMS: To examine whether a multi-faceted intervention among older at-risk drinking primary care patients reduced at-risk drinking and alcohol consumption at 3 and 12 months. DESIGN: Randomized controlled trial. SETTING: Three primary care sites [...]Rapport
Université de Liège ; I. DEMARET ; G. LITRAN ; C. MAGOGA ; C. DEBLIRE ; J. DE ROUBAIX ; E. QUERTEMONT ; D. VAN CAILLIE ; N. DUBOIS ; A. LEMAITRE ; M. ANSSEAU | Université de Liège | 2013Le projet - historique et protocole : Ce projet, qui était en discussion à Liège depuis 1995, a fait l'objet d'un accord définitif en février 2007, date à laquelle les ministres fédéraux de la Santé publique et de la Justice ont annoncé le lanc[...]Article : Périodique
C. BEN LAKHDAR ; A. DEPLANCKE ; F. LE LEC ; S. MASSIN ; A. PIERMATTEO ; N. VAILLANT |INTRODUCTION: Tobacco smoking is one of the leading causes of preventable death. This is not inevitable as tobacco control tools have become more powerful and more effective. Among these, warnings on cigarette packs have proven to be somewhat ef[...]Article : Périodique
G. GMEL ; V. VENZIN ; K. MARMET ; G. DANKO ; F. LABHART |Objectives: To show the effectiveness of a brief group alcohol intervention. Aims of the intervention were to reduce the frequency of heavy drinking occasions, maximum number of drinks on an occasion and overall weekly consumption. Methods: A c[...]Périodique
N. HEATHER ; BOWIE A. ; H. ASHTON ; MC AVOY B. ; I. SPENCER ; BRODIE J. ; GIDDINGS D. | 2004ENGLISH : Previous studies have reported that a letter from the patient's General Practitioner (GP) and a short GP consultation led to reduced intake among long-term benzodiazepine (BZD) users, with no evidence of a deterioration in general or[...]Article : Périodique
L. M. ROBERTS ; S. WILSON ; A. ROALFE ; P. BRIDGE |BACKGROUND: Postal questionnaires are an economical and simple method of data collection for research purposes but are subject to non-response bias. Several studies have explored the effect of monetary and non-monetary incentives on response. Re[...]Article : Périodique
BACKGROUND: A well designed randomized clinical trial rates as the highest level of evidence for a particular intervention's efficacy. Randomization, a fundamental feature of clinical trials design, is a process invoking the use of probability t[...]Article : Périodique
A. SPIRITO ; P. M. MONTI ; N. P. BARNETT ; S. M. COLBY ; H. SINDELAR ; D. J. ROHSENOW ; W. LEWANDER ; M. MYERS |We tested whether a brief motivational interview (MI) would reduce alcohol-related consequences and use among adolescents treated in an emergency department (ED) after an alcohol-related event. Patients aged 13 to 17 years (N = 152) with a posit[...]Article : Périodique
R. HUMENIUK ; R. ALI ; T. F. BABOR ; M. L. SOUZA FORMIGONI ; R. B. DE LACERDA ; W. LING ; B. McREE ; D. NEWCOMBE ; H. PAL ; V. POZNYAK ; S. SIMON ; J. VENDETTI |AIMS: This study evaluated the effectiveness of a brief intervention (BI) for illicit drugs (cannabis, cocaine, amphetamine-type stimulants and opioids) linked to the World Health Organization (WHO) Alcohol, Smoking and Substance Involvement Scr[...]Article : Périodique
D. D. WALKER ; R. STEPHENS ; R. ROFFMAN ; J. DEMARCE ; B. LOZANO ; S. TOWE ; B. BERG |AIMS: Cannabis use adversely affects adolescents and interventions that are attractive to adolescents are needed. This trial compared the effects of a brief motivational intervention for cannabis use with a brief educational feedback control and[...]Article : Périodique
ENGLISH: Aim: We tested the efficacy of a brief intervention based on motivational interviewing (MI) to reduce high-risk injection behaviours over a 6-month period among people who inject drugs (PWID). Design: A single-site two-group parallel [...]Article : Périodique
Aims: To evaluate the efficacy of a telephone-based intervention consisting of four sessions of motivational interviewing (MI) and cognitive behavioural therapy (CBT) designed to assist individuals to reduce their cannabis use and related proble[...]Article : Périodique
M. A. WALTON ; S. RESKO ; K. L. BARRY ; S. T. CHERMACK ; R. A. ZUCKER ; M. A. ZIMMERMAN ; B. M. BOOTH ; F. C. BLOW |Aims: To examine the efficacy of a brief intervention delivered by a therapist (TBI) or a computer (CBI) in preventing cannabis use among adolescents in urban primary care clinics. Design: A randomized controlled trial comparing: CBI and TBI v[...]Article : Périodique
D. M. DOUMAS ; S. ESP ; B. FLAY ; L. BOND |OBJECTIVE: The purpose of this randomized controlled study was to examine the efficacy of a brief, web-based personalized feedback intervention (the eCHECKUP TO GO) on alcohol use and alcohol-related consequences among high school seniors. METH[...]Livre
Randomized controlled trials are one of the most powerful and revolutionary tools of research. This book is a convenient and accessible description of the underlying principles and practice of randomized controlled trials and their role in clini[...]Article : Périodique
M. REYNAUD ; H. J. AUBIN ; F. TRINQUET ; B. ZAKINE ; C. DANO ; M. DEMATTEIS ; B. TROJAK ; F. PAILLE ; M. DETILLEUX |Aims: Alcohol dependence is a major public health issue with a need for new pharmacological treatments. The ALPADIR study assessed the efficacy and safety of baclofen at the target dose of 180 mg/day for the maintenance of abstinence and the red[...]Article : Périodique
P. HAJEK ; A. PHILLIPS-WALLER ; D. PRZULJ ; F. PESOLA ; K. MYERS SMITH ; N. BISAL ; J. LI ; S. PARROTT ; P. SASIENI ; L. DAWKINS ; L. ROSS ; M. GONIEWICZ ; Q. WU ; H. J. MCROBBIE |Background: E-cigarettes are commonly used in attempts to stop smoking, but evidence is limited regarding their effectiveness as compared with that of nicotine products approved as smoking-cessation treatments. Methods: We randomly assigned adu[...]Article : Périodique
M. McKENZIE ; N. ZALLER ; S. L. DICKMAN ; T. C. GREEN ; A. PARIHK ; P. D. FRIEDMANN ; J. D. RICH |Individuals who use heroin and illicit opioids are at high risk for infection with human immunodeficiency virus (HIV) and other blood-borne pathogens, as well as incarceration. The purpose of the randomized trial reported here is to compare outc[...]Article : Périodique
T. COLEMAN ; S. COOPER ; J. G. THORNTON ; M. J. GRAINGE ; K. WATTS ; J. BRITTON ; S. LEWIS ; Smoking, Nicotine, and Pregnancy (SNAP) Trial Team |Background: Nicotine-replacement therapy is effective for smoking cessation outside pregnancy and its use is widely recommended during pregnancy. We investigated the efficacy and safety of nicotine patches during pregnancy. Methods: We recruite[...]Article : Périodique
H. REDDON ; T. KERR ; M. J. MILLOY |Evidence-based medicine has consistently prized the epistemological value of randomized-controlled trials (RCTs) owing to their methodological advantages over alternative designs such as observational studies. However, there are limitations to R[...]Article : Périodique
E. F. KANER ; LOCK C. A. ; McAVOY B. R. ; N. HEATHER ; E. GILVARRY |BACKGROUND: Providing doctors with new research findings or clinical guidelines is rarely sufficient to promote changes in clinical practice. An implementation strategy is required to provide clinicians with the skills and encouragement needed t[...]Article : Périodique
Injection drug initiation usually requires assistance by someone who already injects drugs. To develop interventions that prevent people from starting to inject drugs, it is imperative to understand why people who inject drugs (PWID) assist with[...]Article : Périodique
T. W. KIM ; J. BERNSTEIN ; D. M. CHENG ; C. LLOYD-TRAVAGLINI ; J. H. SAMET ; T. P. PALFAI ; R. SAITZ |Background and Aims: Screening, brief intervention and 'referral to treatment' programs have been promoted widely as US federal policy. Little is known about the efficacy of the RT component (referral to treatment) of brief intervention for moti[...]