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ETUDE RANDOMISEE |
Documents disponibles dans cette catégorie (227)
Article : Périodique
D. LÉCALLIER ; F. HADJ-SLIMANE ; M. LANDRY ; P. BRISTOL-GAUZY ; C. CORDOLIANI ; M. GRÉLOIS ; C. DELVA ; P. MICHAUD |FRANÇAIS : Objectifs : Le questionnaire DEP-ADO évalue les risques liés aux substances psycho-actives (SPA) chez les adolescents, en distinguant trois niveaux, faible (feu vert), intermédiaire (feu jaune) et élevé (feu rouge). Nous avons évalué[...]Article : Périodique
This article reviews the evidence in support of current treatment dropout responses designed for use in outpatient, psychosocial-based alcohol and other drug (AOD) treatment settings. A total of 17 publications meeting the inclusion criteria wer[...]Périodique
D. LUCIDARME ; A. DECOSTER ; D. FREMAUX ; J. HARBONNIER ; C. JACOB ; V. VOSGIEN ; P. JOSSE ; P. VILLEGER ; C. HENRIO ; B. PROUVOST-KELLER ; C. SACCARDY ; M. LEMAIRE ; G. VAZEILLE ; C. DUCHENE ; M. THUILLIER ; C. COLBEAUX ; A. M. LEFEBVRE ; G. FORZY ; B. FILOCHE | 2007FRANÇAIS : But : Le but de cette étude randomisée multicentrique était d'évaluer l'apport diagnostique du dépistage de l'infection par le VHC sur prélèvement salivaire en pratique quotidienne dans la population toxicomane. Méthodes : Entre janv[...]Article : Périodique
S. G. MITCHELL ; R. P. SCHWARTZ ; A. S. KIRK ; K. DUSEK ; M. OROS ; C. HOSLER ; J. GRYCZYNSKI ; C. BARBOSA ; L. DUNLAP ; D. LOUNSBURY ; K. E. O'GRADY ; B. S. BROWN |Background: Alcohol, tobacco, and other drug use remains highly prevalent among US adolescents and is a threat to their well-being and to the public health. Evidence from clinical trials and meta-analyses supports the effectiveness of Screening,[...]Article : Périodique
R. SAITZ ; T. PALFAI ; D. M. CHENG ; D. P. ALFORD ; J. A. BERNSTEIN ; C. LLOYD-TRAVAGLINI ; S. M. MELI ; C. E. CHAISSON ; J. H. SAMET |Importance: The United States has invested substantially in screening and brief intervention for illicit drug use and prescription drug misuse, based in part on evidence of efficacy for unhealthy alcohol use. However, it is not a recommended uni[...]Article : Périodique
C. J. CHERPITEL ; J. MOSKALEWICZ ; G. SWIATKIEWICZ ; Y. YE ; J. BOND |OBJECTIVE: A randomized, controlled trial of screening, brief intervention, and referral to treatment (SBIRT) for drinking and related problems among at-risk and dependent drinkers was conducted in an emergency department (ED) in Sosnowiec, Pola[...]Article : Périodique
Background: There are epidemiological data indicating that medical and/or nonmedical use of prescription opioids oftentimes involves concurrent use of other substances. One of those substances is benzodiazepines. It would be of relevance to char[...]Article : Périodique
S. A. BALL ; S. MARTINO ; C. NICH ; T. L. FRANKFORTER ; D. VAN HORN ; P. CRITS-CHRISTOPH ; G. E. WOODY ; J. L. OBERT ; C. FARENTINOS ; K. M. CARROLL ; National Institute on Drug Abuse Clinical Trials Network |The effectiveness of motivational enhancement therapy (MET) in comparison with counseling as usual (CAU) for increasing retention and reducing substance use was evaluated in a multisite randomized clinical trial. Participants were 461 outpatient[...]Article : Périodique
Background and aims: Brief alcohol interventions in medical settings are efficacious in improving self-reported alcohol consumption among those with low-severity alcohol problems. Screening, Brief Intervention and Referral to Treatment initiativ[...]Article : Périodique
J. KAKKO ; GRÖNBLADH L. ; K. D. SVANBORG ; J. VON WACHENFELDT ; RÜCK C. ; RAWLINGS B. ; NILSSON L. H. ; M. HEILIG |OBJECTIVE: Both methadone and buprenorphine are effective therapy for heroin dependence. Efficacy is best documented for methadone maintenance therapy, but safety concerns limit its use. Buprenorphine offers lower overdose risk and improved acce[...]Article : Périodique
J. STRANG ; N. METREBIAN ; N. LINTZERIS ; L. POTTS ; T. CARNWATH ; S. MAYET ; H. WILLIAMS ; D. ZADOR ; R. EVERS ; T. GROSHKOVA ; V. CHARLES ; A. MARTIN ; L. FORZISI |Background: Some heroin addicts persistently fail to benefit from conventional treatments. We aimed to compare the effectiveness of supervised injectable treatment with medicinal heroin (diamorphine or diacetylmorphine) or supervised injectable [...]Article : Périodique
BACKGROUND: Several systematic reviews of school-based smoking prevention trials have shown short-term decreases in smoking prevalence but have not examined long-term follow-up evaluation. The purpose of this study was to conduct a systematic re[...]Article : Périodique
Background: The aim of this study is to investigate the effects of an Internet-based screening and brief intervention (SBI) site for problematic alcohol and drug use among illicit drug users. Method: Individuals searching for information about[...]Article : Périodique
B. C. BOCK ; N. P. BARNETT ; H. THIND ; R. ROSEN ; K. WALASKA ; R. TRAFICANTE ; R. FOSTER ; C. DEUTSCH ; J. L. FAVA ; L. A. J. SCOTT-SHELDON |ENGLISH: Background: Students at community colleges comprise nearly half of all U.S. college students and show higher risk of heavy drinking and related consequences compared to students at 4-year colleges, but no alcohol safety programs curren[...]Article : Périodique
I. K. CROMBIE ; L. IRVINE ; B. WILLIAMS ; F. F. SNIEHOTTA ; D. PETRIE ; C. JONES ; J. NORRIE ; J. M. M. EVANS ; C. EMSLIE ; P. M. RICE ; P. W. SLANE ; G. HUMPHRIS ; I. W. RICKETTS ; A. J. MELSON ; P. T. DONNAN ; S. M. HAPCA ; A. MCKENZIE ; M. ACHISON |Aims: To test the effectiveness of a theoretically based text-message intervention to reduce binge drinking among socially disadvantaged men. Design: A multi-centre parallel group, pragmatic, individually randomized controlled trial. Setting:[...]Périodique
M. FERRI ; M. DAVOLI ; F. FAGGIANO ; L. AMATO ; C. A. PERUCCI | 2003ENGLISH : The Cochrane Drugs and Alcohol Review Group is part of Cochrane Collaboration, which was established in the UK, in 1992, with the aim of producing and disseminating systematic reviews of the effects of healthcare interventions. The G[...]Article : Périodique
FRANÇAIS : Les essais randomisés contrôlés (ERC) font partie des études les plus performants pour évaluer les effets des interventions de soins. Il est impossible cependant de connaître tous les ERC réalisés. Une recherche sur Medline et sur d[...]Article : Périodique
R. DHITAL ; I. NORMAN ; C. WHITTLESEA ; T. MURRELLS ; J. McCAMBRIDGE |Background and Aims: To undertake the first randomized controlled trial to evaluate the effectiveness of a brief intervention delivered by community pharmacists to reduce hazardous or harmful drinking. Design: This parallel group randomized tri[...]Article : Périodique
In order to quantify the effectiveness of family interventions in preventing and reducing adolescent illicit drug use, we conducted a systematic review and meta-analysis of randomized controlled trials. We searched the Cochrane Database of Syste[...]Article : Périodique
F. FAGGIANO ; M. R. GALANTI ; K. BOHRN ; G. BURKHART ; F. VIGNA-TAGLIANTI ; L. CUOMO ; L. FABIANI ; M. PANELLA ; T. PEREZ ; R. SILIQUINI ; P. VAN DER KREEFT ; M. VASSARA ; G. WIBORG ; EU-Dap Study Group |OBJECTIVE: To evaluate the effectiveness of the school-based drug abuse prevention program developed in the EU-Dap study (EUropean Drug Abuse Prevention trial) in preventing the use of tobacco, alcohol and drugs at the post-test. METHODS: Clust[...]Article : Périodique
Aims: To evaluate the effectiveness of a web-based brief alcohol intervention 'What Do You Drink' (WDYD) among heavy drinking students at 1- and 6-month post-intervention. Additionally, it was investigated whether certain subgroups would benefit[...]Article : Périodique
OBJECTIVES: This study tested the hypothesis that adoption and implementation of local policies regarding youth access to tobacco can affect adolescent smoking. METHODS: A randomized community trial was conducted in 14 Minnesota communities. S[...]Article : Périodique
C. DIAZ GOMEZ ; A. MOREL ; I. SEDANO ; H. J. AUBIN |Alcohol and tobacco use is a major health problem and one of the first causes of the burden of disease and mortality. School-based alcohol and tobacco use prevention programmes that have demonstrated efficacy are most often based on psychosocial[...]Périodique
J. McCAMBRIDGE ; J. STRANG | 2004FRANÇAIS : L'essai randomisé a porté sur 200 jeunes (16-20 ans), dont 105 ont suivi un entretien motivationnel de 1 heure en face à face et 95 ont constitué le groupe témoin. La comparaison des consommations auto-déclarées et des perceptions d[...]Rapport
D. NABER ; C. HAASEN | Hamburg : Centre for Interdisciplinary Addiction Research of Hamburg University (ZIS) | 2006ENGLISH : The German project of heroin assisted treatment of opiate dependent patients addresses drug addicts who were not successfully treated by the existing addiction therapies or whose course of methadone maintenance treatment was not sati[...]Rapport
Article : Périodique
BACKGROUND AND AIMS: Increasing numbers of school-based drug surveys are transitioning data collection to electronic tablets from paper-and-pencil, which may produce a survey mode effect and consequent discontinuity in time trends for population[...]Article : Périodique
T. SLADE ; N. C. NEWTON ; M. MATHER ; E. L. BARRETT ; K. E. CHAMPION ; L. STAPINSKI ; P. J. CONROD ; M. TEESSON |AIM: To compare the long-term universal outcomes of the Climate Schools programme, the selective preventure programme and their combined implementation to standard substance use education in reducing the uptake of alcohol use, engagement in bing[...]Article : Périodique
Aims: This study aimed to assess the effectiveness of the Örebro prevention programme (ÖPP), an alcohol misuse prevention programme that aims to reduce youth drinking by changing parental behaviour. Design: Cluster-randomized trial, with schoo[...]Article : Périodique
AIMS Sublingual buprenorphine and buprenorphine/naloxone are efficacious opioid dependence pharmacotherapies, but there are reports of their diversion and misuse by the intranasal route. The study objectives were to characterize and compare thei[...]Article : Périodique
R. DE BEAUREPAIRE ; J. M. A. SINCLAIR ; M. HEYDTMANN ; G. ADDOLORATO ; H. J. AUBIN ; E. M. BERAHA ; F. CAPUTO ; J. D. CHICK ; P. DE LA SELLE ; N. FRANCHITTO ; J. C. GARBUTT ; P. S. HABER ; P. JAURY ; A. R. LINGFORD-HUGHES ; K. C. MORLEY ; C. A. MULLER ; L. OWENS ; A. PASTOR ; L. M. PATERSON ; F. PELISSIER ; B. ROLLAND ; A. STAFFORD ; A. THOMPSON ; W. VAN DEN BRINK ; L. LEGGIO ; R. AGABIO |Alcohol use disorder (AUD) is a brain disorder associated with high rates of mortality and morbidity worldwide. Baclofen, a selective gamma-aminobutyric acid-B (GABA-B) receptor agonist, has emerged as a promising drug for AUD. The use of this d[...]Article : Périodique
L. RIGAL ; S. SIDORKIEWICZ ; J. M. TRELUYER ; E. PERRODEAU ; C. LE JEUNNE ; R. PORCHER ; P. JAURY |Background and Aims: Baclofen is a promising drug for treating patients with alcohol-related disorders. Nevertheless, the first randomized clinical trials (mainly with target doses) reported inconsistent efficacy, possibly because of the effecti[...]Article : Périodique
Aims: To assess the efficacy of topiramate in treating cocaine use disorder (i.e. retention, efficacy, safety and craving reduction) through a systematic review and meta-analysis. Methods: We searched six scientific databases from inception to[...]Article : Périodique
B. A. JOHNSON ; N. AIT-DAOUD ; X. Q. WANG ; J. K. PENBERTHY ; M. A. JAVORS ; C. SENEVIRATNE ; L. LIU |IMPORTANCE: No medication has been established as an efficacious treatment for cocaine dependence. We hypothesized that dual modulation of the mesocorticolimbic dopamine system by topiramate-a glutamate receptor antagonist and.-aminobutyric acid[...]Article : Périodique
S. J. BECKER ; A. SPIRITO ; L. HERNANDEZ ; N. P. BARNETT ; C. A. EATON ; W. LEWANDER ; D. J. ROHSENOW ; P. M. MONTI |Objective: The primary aim of this study was to identify distinct classes of trajectories of adolescent substance use following a brief motivational interviewing (MI) intervention in an Emergency Department (ED). The secondary aim was to identif[...]Article : Périodique
BACKGROUND: To meet the treatment needs of the growing number of adolescents who seek help for cannabis use problems, new or supplementary types of treatment are needed. We investigated whether multidimensional family therapy (MDFT) was more eff[...]Article : Périodique
Y. I. HSER ; A. J. SAXON ; D. HUANG ; A. HASSON ; C. THOMAS ; M. HILLHOUSE ; P. JACOBS ; C. TERUYA ; P. McLAUGHLIN ; K. WIEST ; A. COHEN ; W. LING |Aims: To examine patient and medication characteristics associated with retention and continued illicit opioid use in methadone (MET) versus buprenorphine/naloxone (BUP) treatment for opioid dependence. Design, settings and participants: This s[...]Article : Périodique
BACKGROUND: Alcohol misuse in young people is a cause of concern for health services, policy makers, prevention workers, and criminal justice system, youth workers, teachers, and parents. OBJECTIVES: To systematically review evidence on the ef[...]Article : Périodique
BACKGROUND: Alcohol misuse in young people is a cause of concern for health services, policy makers, prevention workers, and criminal justice system, youth workers, teachers, and parents. OBJECTIVES: To systematically review evidence on the ef[...]Article : Périodique
BACKGROUND: Alcohol misuse in young people is cause of concern for health services, policy makers, prevention workers, criminal justice system, youth workers, teachers, parents. This is one of three reviews examining the effectiveness of (1) sch[...]Article : Périodique
M. MIOVSKY ; H. VONKOVA ; R. GABRHELIK ; L. STASTNA |This study aims to examine the effect of school-based preventive intervention on cannabis use in Czech adolescents with different levels of risk factors and provide evidence of its universality. A randomized controlled prevention trial with six [...]Article : Périodique
T. WEAVER ; N. METREBIAN ; J. HELLIER ; S. PILLING ; V. CHARLES ; N. LITTLE ; D. POOVENDRAN ; L. MITCHESON ; F. RYAN ; O. BOWDEN-JONES ; J. DUNN ; GLASPER A. ; E. FINCH ; J. STRANG |BACKGROUND. Poor adherence to treatment diminishes its individual and public health benefit. Financial incentives, provided on the condition of treatment attendance, could address this problem. Injecting drug users are a high-risk group for hepa[...]Article : Périodique
K. KYPRI ; T. VATER ; S. J. BOWE ; J. B. SAUNDERS ; J. A. CUNNINGHAM ; N. J. HORTON ; J. McCAMBRIDGE |Importance: Unhealthy alcohol use is a leading contributor to the global burden of disease, particularly among young people. Systematic reviews suggest efficacy of web-based alcohol screening and brief intervention and call for effectiveness tri[...]Article : Périodique
L. A. MARSCH ; H. GUARINO ; M. ACOSTA ; Y. APONTE-MELENDEZ ; C. CLELAND ; M. GRABINSKI ; R. BRADY ; J. EDWARDS |This study is the first experimental trial to evaluate the effectiveness of a Web-based behavioral intervention when deployed in a model where it partially substituted for standard counseling in a community-based specialty addiction treatment pr[...]Article : Périodique
C. SUNDSTROM ; N. EEK ; M. KRAEPELIEN ; V. KALDO ; A. H. BERMAN |INTRODUCTION: Internet interventions for alcohol problems are effective, but not all participants are helped. Further, the importance of adherence has often been neglected in research on internet interventions for alcohol problems. Prediction an[...]Périodique
When treatment meets research: clinical perspectives from the CSAT methamphetamine treatment project
J. L. OBERT ; A. H. BROWN ; J. ZWEBEN ; D. CHRISTIAN ; DELMHORST J. ; MINSKY S. ; MORRISEY P. ; D. VANDERSLOOT ; A. WEINER | 2005ENGLISH : Integrating research-based treatments into clinical settings has become a priority in the substance abuse treatment field. This article examines the introduction of research, via manualized treatment (i.e., the Matrix Model), into co[...]