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ETUDE RANDOMISEE |
Documents disponibles dans cette catégorie (226)
Article : Périodique
Adult marijuana users (N = 291) seeking treatment were randomly assigned to an extended 14-session cognitive-behavioral group treatment (relapse prevention support group; RPSG), a brief 2-session individual treatment using motivational interview[...]Article : Périodique
N. M. J. WRIGHT ; L. SHEARD ; C. E. ADAMS ; B. J. RUSHFORTH ; W. HARRISON ; N. BOUND ; R. HART ; C. N. E. TOMPKINS |BACKGROUND: Many opiate users require prescribed medication to help them achieve abstinence, commonly taking the form of a detoxification regime. In UK prisons, drug users are nearly universally treated for their opiate use by primary care clini[...]Article : Périodique
Recent studies have demonstrated the therapeutic potential of cannabinoids to treat pain, yet none have compared the analgesic effectiveness of smoked marijuana to orally administered Δ9-tetrahydrocannabinol (THC; dronabinol). This randomized, p[...]Article : Périodique
S. ROOKE ; E. B. THORSTEINSSON ; A. KARPIN ; J. COPELAND ; D. ALLSOP |AIMS: To quantify the overall effectiveness of computer-delivered interventions for alcohol and tobacco use. METHODS: Meta-analysis of 42 effect sizes from randomized controlled trials, based on the responses of 10 632 individuals. RESULTS: [...]Article : Périodique
FRANÇAIS : La réduction du tabagisme dans les populations socialement défavorisées est une composante importante de la réduction des inégalités sociales de santé. Pour cela, outre la prévention de l'initiation tabagique au sein de ces populatio[...]Article : Périodique
J. LI ; P. HAJEK ; F. PESOLA ; Q. WU ; A. PHILLIPS-WALLER ; D. PRZULJ ; K. MYERS SMITH ; N. BISAL ; P. SASIENI ; L. DAWKINS ; L. ROSS ; M. L. GONIEWICZ ; H. McROBBIE ; S. PARROTT |AIM: To evaluate the cost-effectiveness of e-cigarettes as a smoking cessation aid used in routine stop smoking services in England. DESIGN: Cost-effectiveness analysis was performed from the National Health Service (NHS) and Personal Social Se[...]Article : Périodique
S. BYFORD ; B. BARRETT ; N. METREBIAN ; T. GROSHKOVA ; M. CARY ; V. CHARLES ; N. LINTZERIS ; J. STRANG |Background: Despite evidence of the effectiveness of injectable opioid treatment compared with oral methadone for chronic heroin addiction, the additional cost of injectable treatment is considerable, and cost-effectiveness uncertain. Aims: To[...]Article : Périodique
N. A. RIGOTTI ; N. L. BENOWITZ ; J. PROCHASKA ; S. LEISCHOW ; M. NIDES ; B. BLUMENSTEIN ; A. CLARKE ; D. CAIN ; C. JACOBS |Key Points: Question: Is cytisinicline an effective and safe pharmacotherapy to promote smoking cessation? Findings: In a randomized clinical trial that included 810 adults who smoked, both a 6-week and a 12-week course of a novel cytisiniclin[...]Article : Périodique
M. D. STEIN ; C. M. CAVINESS ; E. F. MORSE ; K. R. GRIMONE ; D. AUDET ; D. S. HERMAN ; E. MOITRA ; B. J. ANDERSON |Aims: To test the hypothesis that among non-treatment-seeking emerging adults (EA) who both use marijuana and have alcohol binges, a brief, longitudinally delivered, developmentally based motivational intervention would show greater reductions i[...]Article : Périodique
E. OVIEDO-JOEKES ; S. BRISSETTE ; D. C. MARSH ; P. LAUZON ; D. GUH ; A. ANIS ; M. T. SCHECHTER |BACKGROUND: Studies in Europe have suggested that injectable diacetylmorphine, the active ingredient in heroin, can be an effective adjunctive treatment for chronic, relapsing opioid dependence. METHODS: In an open-label, phase 3, randomized, [...]Article : Périodique
I. SOHI ; K. D. SHIELD ; J. REHM ; M. MONTEIRO |This article updates a 2017 review on the effectiveness of digital interventions for reducing alcohol use in the general population. An updated systematic search of the MEDLINE database was performed in accordance with the Preferred Reporting It[...]Article : Périodique
Does cessation of smoking cause a change in alcohol consumption? Evidence from the Lung Health study
FRANÇAIS : Quoiqu'une relation positive existe entre l'utilisation de cigarettes et la consommation d'alcool, il n'est pas évident si un changement dans l'utilisation de cigarettes est suivi par un changement de la consommation d'alcool. L'étu[...]Article : Périodique
L. AMATO ; S. MINOZZI ; P. P. PANI ; R. SOLIMINI ; S. VECCHI ; P. ZUCCARO ; M. DAVOLI |BACKGROUND: Cocaine dependence is a disorder for which no pharmacological treatment of proven efficacy exists, advances in the neurobiology could guide future medication development. OBJECTIVES: To investigate the efficacy and acceptability of [...]Article : Périodique
G. ADDOLORATO ; L. LEGGIO ; A. FERRULLI ; S. CARDONE ; G. BEDOGNI ; F. CAPUTO ; G. GASBARRINI ; R. LANDOLFI ; Baclofen Study Group |AIMS: To explore the effect of baclofen in a dose of 20 mg three times per day, compared with the already studied dose of 10 mg three times per day, in the treatment of alcohol dependence. METHODS: We present a secondary analysis of a 12-week do[...]Rapport
T. T. MENSINGA ; I. DE VRIES ; M. KRUIDENIER ; C. C. HUNAULT ; I. S. VAN DEN HENGEL-KOOT ; J. W. FIJEN ; M. E. C. LEENDERS ; J. MEULENBELT | Bilthoven : RIVM | 2006Systematic measurements of the concentration of the psycho-active substance delta-9-tetrahydrocannabinol (THC) in 'netherweed' cannabis obtained from coffeeshops in the Netherlands have revealed that the mean THC concentrations have steadily inc[...]Article : Périodique
F. R. LEVIN ; J. J. MARIANI ; D. J. BROOKS ; M. PAVLICOVA ; W. CHENG ; E. V. NUNES |Cannabis dependence is a substantial public health problem. Behavioral treatments have shown promise, but there are no effective medications for cannabis dependence. The purpose of this study was to evaluate the safety and efficacy of dronabinol[...]Périodique
DEHUE T. | 2002ENGLISH : In 1995, the Dutch Minister of Health proposed that a randomized clinical trial (RCT) with heroin-maintenance for severe abusers be conducted. It took nearly four years of lengthy debates before the Dutch Parliament consented to the [...]Article : Périodique
C. DIAZ GOMEZ ; M. NGANTCHA ; N. LE GARJEAN ; N. BROUARD ; M. LASBLEIZ ; M. PERENNES ; F. J. KERDILES ; C. LE LAN ; R. MOIRAND ; A. BELLOU |Background: Introduction to alcohol consumption early in life increases the risk of alcohol dependency and hence motivational interventions are needed in young patients visiting the emergency department (ED). Aim: This study aims to investigate[...]Article : Périodique
S. L. WALSH ; S. D. COMER ; M. R. LOFWALL ; B. VINCE ; N. LEVY-COOPERMAN ; D. KELSH ; M. A. COE ; J. D. JONES ; P. A. NUZZO ; F. TIBERG ; B. SHELDON ; S. KIM |Importance: Buprenorphine is an efficacious, widely used treatment for opioid use disorder (OUD). Daily oral transmucosal formulations can be associated with misuse, diversion, and nonadherence; these limitations may be obviated by a sustained r[...]Article : Périodique
T. R. ARKELL ; F. VINCKENBOSCH ; R. C. KEVIN ; E. L. THEUNISSEN ; I. S. MCGREGOR ; J. G. RAMAEKERS |Question: What is the magnitude and duration of driving impairment following vaporization of cannabis containing varying concentrations of Delta9-tetrahydrocannabinol (THC) and cannabidiol (CBD)? Findings: In this crossover clinical trial that [...]Article : Périodique
TONSTAD S. ; TONNESEN P. ; P. HAJEK ; K. WILLIAMS ; C. BILLING ; K. REEVES ; Varenicline Phase 3 Study Group |FRANÇAIS : Cet essai a pour objectif de déterminer si un traitement de 12 semaines supplémentaires par la varenicline augmente les taux d'abstinence du tabac chez des fumeurs ayant reçu un traitement initial par la varenicline durant 12 semain[...]Article : Périodique
N. BERTHOLET ; E. SCHMUTZ ; J. STUDER ; A. ADAM ; G. GMEL ; J. A. CUNNINGHAM ; J. McNEELY ; J. B. DAEPPEN |Objective: To estimate the effects of providing access to an alcohol intervention based on a smartphone. Design: Randomised controlled trial. Setting: Four higher education institutions in Switzerland. Participants: 1770 students (> =18 yea[...]Article : Périodique
S. HARTLEY ; N. SIMON ; A. LARABI ; I. VAUGIER ; F. BARBOT ; M. A. QUERA-SALVA ; J. C. ALVAREZ |BACKGROUND: The pharmacokinetic-pharmacodynamic relationship between whole blood delta-9-tetrahydrocannabinol (THC) and driving risk is poorly understood. METHODS: Fifteen chronic cannabis consumers (1-2 joints/day; CC) and 15 occasional cannab[...]Article : Périodique
J. M. McQUEEN ; T. E. HOWE ; C. BALLINGER ; J. GODWIN |OBJECTIVE: The purpose of this study was to examine the effectiveness of an alcohol brief intervention (ABI) on alcohol consumption in hazardous or harmful drinkers compared with screening alone within a general hospital setting. METHOD: Follow[...]Article : Périodique
J. LERCH ; S. T. WALTERS ; L. TANG ; F. S. TAXMAN |As many as 80% of the nearly five million adults under community supervision (i.e., probation, parole) are substance involved; however, treatment utilization is low. Using a multi-site randomized controlled trial, we tested the efficacy of in-pe[...]Article : Périodique
Research Summary: Study randomly assigned 235 offenders to drug treatment court (DTC) or "treatment as usual." Analyses of official records collected over a two-year follow-up period show that DTC is reducing crime in a population of drug-addict[...]Article : Périodique
BACKGROUND: Self-help interventions without professional contact to curb adult problem drinking in the community are increasingly being delivered via the Internet. OBJECTIVE: The objective of this meta-analysis was to assess the overall effect[...]Article : Périodique
E. KANER ; M. BLAND ; P. CASSIDY ; S. COULTON ; V. DALE ; P. DELUCA ; E. GILVARRY ; C. GODFREY ; N. HEATHER ; J. MYLES ; D. NEWBURY-BIRCH ; A. OYEFESO ; S. PARROTT ; K. A. PERRYMAN ; T. PHILLIPS ; J. SHEPHERD ; C. DRUMMOND |Objective: To evaluate the effectiveness of different brief intervention strategies at reducing hazardous or harmful drinking in primary care. The hypothesis was that more intensive intervention would result in a greater reduction in hazardous o[...]Article : Périodique
P. J. CONROD ; M. O'LEARY-BARRETT ; N. NEWTON ; L. TOPPER ; N. CASTELLANOS-RYAN ; C. MACKIE ; A. GIRARD |FRANÇAIS : Cette étude randomisée montre qu'un programme de prévention ciblé sur les adolescents présentant une personnalité « à risque » semble avoir un effet durable pour limiter leur consommation d'alcool, lorsqu'il est mis en œuvre par des [...]Article : Périodique
S. ROOKE ; J. COPELAND ; M. NORBERG ; D. HINE ; J. McCAMBRIDGE |BACKGROUND: Self-help strategies offer a promising way to address problems with access to and stigma associated with face-to-face drug and alcohol treatment, and the Internet provides an excellent delivery mode for such strategies. To date, no s[...]Article : Périodique
M. MALMBERG ; M. KLEINJAN ; G. OVERBEEK ; A. VERMULST ; K. MONSHOUWER ; J. LAMMERS ; W. A. M. VOLLEBERGH ; R. C. M. E. ENGELS |Aim: To evaluate the effectiveness of the Healthy School and Drugs programme on alcohol, tobacco and marijuana use among Dutch early adolescents. Design: Randomized clustered trial with two intervention conditions (i.e. e-learning and integral[...]Article : Périodique
M. MALMBERG ; G. OVERBEEK ; M. KLEINJAN ; A. VERMULST ; K. MONSHOUWER ; J. LAMMERS ; W. A. M. VOLLEBERGH ; R. C. M. E. ENGELS |BACKGROUND: Substance use is highly prevalent among Dutch adolescents. The Healthy School and Drugs program is a nationally implemented school-based prevention program aimed at reducing early and excessive substance use among adolescents. Althou[...]Article : Périodique
Aim: To evaluate the effectiveness of an online school-based prevention program for ecstasy (MDMA) and new psychoactive substances (NPS). Design: Cluster randomized controlled trial with two groups (intervention and control). Setting: Eleven s[...]Article : Périodique
BACKGROUND: Current insights indicate that Web-based delivery may enhance the implementation of brief alcohol interventions. Previous research showed that electronically delivered brief alcohol interventions decreased alcohol use in college stud[...]Article : Périodique
M. A. WALTON ; S. T. CHERMACK ; J. T. SHOPE ; C. R. BINGHAM ; M. A. ZIMMERMAN ; F. C. BLOW ; R. M. CUNNINGHAM |Context: Emergency department (ED) visits present an opportunity to deliver brief interventions to reduce violence and alcohol misuse among urban adolescents at risk of future injury. Objective: To determine the efficacy of brief interventions[...]Périodique
L. A. VENTURA ; E. G. LAMBERT | 2005This study explored the effects of specific types of substance abuse treatment services on clients remaining arrest free for the year following services. The sample consisted of clients admitted to the Lucas County Alcohol and Drug Addiction Ser[...]Article : Périodique
Purpose: School-based substance abuse prevention programs are widespread but are rarely evaluated in Europe. We aimed to evaluate the effect of a new school-based prevention program against substance use on the frequency of alcohol consumption a[...]Article : Périodique
C. GIROUD ; M. AUGSBURGER ; B. FAVRAT ; A. MENETREY ; M. A. PIN ; L. E. ROTHUIZEN ; M. APPENZELLER ; T. BUCLIN ; S. MATHIEU ; CASTELLA V. ; A. HAZEKAMP ; P. MANGIN |FRANÇAIS : Deux études épidémiologiques successives ont montré que le cannabis était en première position des substances psychoactives détectées dans le sang des conducteurs soupçonnés de conduire sous l'influence de produits psychotropes. Une[...]Article : Périodique
FRANÇAIS : En préalable au projet belge TADAM (un essai clinique de traitement assisté par diacétylmorphine), notre équipe de recherche a étudié les essais cliniques réalisés à l'étranger. Depuis 1994, six études contrôlées randomisées ont été[...]Article : Périodique
BACKGROUND: People who smoke conventional cigarettes are increasingly turning to electronic cigarettes (e-cigarettes) as a pathway to quitting. However, the efficacy and safety of e-cigarettes for smoking cessation remains controversial. METHO[...]Article : Périodique
BACKGROUND: Many studies reported that brief interventions are effective in reducing excessive drinking. This study aimed to assess the efficacy of a protocol of brief intervention for college students (BASICS), delivered face-to-face, to reduce[...]Article : Périodique
J. B. DAEPPEN ; N. BERTHOLET ; J. GAUME ; C. FORTINI ; M. FAOUZI ; G. GMEL |Background: Brief motivational intervention (BMI) is one of the few effective strategies targeting alcohol consumption, but has not been tested in young men in the community. We evaluated the efficacy of BMI in reducing alcohol use and related p[...]Article : Périodique
H. X. LIN ; Z. LIU ; P. HAJEK ; W. T. ZHANG ; Y. WU ; B. C. ZHU ; H. H. LIU ; Q. XIANG ; Y. ZHANG ; S. B. LI ; F. PESOLA ; Y. Y. WANG |Key Points: Question: How do electronic cigarettes (ECs) as a stop-smoking aid compare with efficacy of varenicline and nicotine chewing gum? Findings: In this randomized clinical trial including 1068 smokers, ECs were as effective as varenicl[...]Article : Périodique
R. F. ANTON ; P. LATHAM ; K. VORONIN ; S. BOOK ; M. HOFFMAN ; J. PRISCIANDARO ; E. BRISTOL |Importance: Although an estimated 30 million people meet criteria for alcohol use disorder (AUD), few receive appropriate pharmacotherapy. A more personalized, symptom-specific, approach might improve efficacy and acceptance. Objective: To exam[...]Article : Périodique
I. DEMARET ; E. QUERTEMONT ; G. LITRAN ; C. MAGOGA ; C. DEBLIRE ; N. DUBOIS ; J. DE ROUBAIX ; C. CHARLIER ; A. LEMAITRE ; M. ANSSEAU |Background/Aims: Heroin-assisted treatment (HAT) can improve the condition of heroin addicts still using street heroin after a methadone treatment. In Belgium, a new trial compared the efficacy of a HAT to existing methadone maintenance treatmen[...]Article : Périodique
E. VALDIVIESO LOPEZ ; C. REY-RENONES ; T. RODRIGUEZ-BLANCO ; C. FERRE GRAU ; V. ARIJA ; M. L. BARRERA URIARTE ; E. GRANADO-FONT ; G. FLORES-MATEO ; TAB_ES Study Group |Aims: To evaluate the efficacy of a school-based educational programme in reducing the incidence and prevalence of smoking in secondary school students (compulsory secondary education: CSE) in Catalonia (Spain). Design: Cluster-randomized contr[...]Article : Périodique
E. HOCH ; R. NOACK ; J. HENKER ; A. PIXA ; M. HÖFLER ; S. BEHRENDT ; G. BÜHRINGER ; H. U. WITTCHEN |AIMS: To examine the efficacy, 3- and 6-month follow-up effects of a psychological treatment for older adolescents and adults with DSM-IV cannabis use disorders. The program was tailored to the needs of this patient population. EXPERIMENTAL PRO[...]Article : Périodique
Background and aims: Binge drinking is a widespread practice among adolescents worldwide and is associated with various harmful consequences. Theory-based interventions are a promising approach to prevent this drinking behaviour in this populati[...]Article : Périodique
L. BALDACARA ; H. COGO-MOREIRA ; B. L. PARREIRA ; T. A. DINIZ ; J. J. MILHOMEM ; C. C. FERNANDES ; A. L. LACERDA |OBJECTIVE: We performed a double-blind, randomized, placebo-controlled trial to assess the efficacy of topiramate in the treatment of crack cocaine dependence. METHOD: Sixty men who were dependent on cocaine (DSM-IV) (exclusive use of crack coc[...]Article : Périodique
D. E. JORENBY ; J. HAYS ; N. A. RIGOTTI ; S. AZOULAY ; WATSKY E. ; C. BILLING ; GONG J. ; K. REEVES ; Varenicline Phase 3 Study Group |FRANÇAIS : Cet essai thérapeutique a pour objectif de déterminer l'efficacité et la tolérance de la varenicline (un agoniste partiel du récepteur nicotinique) dans l'aide au sevrage tabagique. Les résultats montrent l'efficacité et la bonne to[...]