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ETUDE RANDOMISEE |
Documents disponibles dans cette catégorie (226)
Article : Périodique
J. BERNSTEIN ; T. HEEREN ; E. EDWARD ; D. DORFMAN ; C. BLISS ; M. WINTER ; E. BERNSTEIN |OBJECTIVES: Adolescents in their late teens and early 20s have the highest alcohol consumption in the United States; binge drinking peaks at age 21-25 years. Underage drinking is associated with many negative consequences, including academic pro[...]Article : Périodique
CONTEXT: Selective interventions targeting personality risk are showing promise in the prevention of problematic drinking behavior, but their effect on illicit drug use has yet to be evaluated. OBJECTIVE: To investigate the efficacy of targete[...]Article : Périodique
T. CARNEY ; B. J. MYERS ; J. LOUW ; C. I. OKWUNDU |BACKGROUND: Adolescent substance use is a major problem in and of itself, and because it acts as a risk factor for other problem behaviours. As substance use during adolescence can lead to adverse and often long-term health and social consequenc[...]Article : Périodique
R. N. ROSENTHAL ; W. LING ; P. CASADONTE ; F. VOCCI ; G. L. BAILEY ; K. KAMPMAN ; A. A. PATKAR ; S. CHAVOUSTIE ; C. BLASEY ; S. C. SIGMON ; K. L. BEEBE |Aims: To evaluate the safety and efficacy of buprenorphine implants (BI) versus placebo implants (PI) for the treatment of opioid dependence. A secondary aim compared BI to open-label sublingual buprenorphine/naloxone tablets (BNX). Design: Ran[...]Article : Périodique
W. LING ; P. CASADONTE ; G. BIGELOW ; K. M. KAMPMAN ; A. A. PATKAR ; G. L. BAILEY ; R. N. ROSENTHAL ; K. L. BEEBE |Context: Limitations of existing pharmacological treatments for opioid dependence include low adherence, medication diversion, and emergence of withdrawal symptoms. Objective: To determine the efficacy of buprenorphine implants that provide a l[...]Article : Périodique
Aims: To examine the effectiveness of a personality-targeted intervention program (Adventure trial) delivered by trained teachers to high-risk (HR) high-school students on reducing marijuana use and frequency of use. Design: A cluster-randomize[...]Article : Périodique
E. HOCH ; G. BÜHRINGER ; A. PIXA ; K. DITTMER ; J. HENKER ; A. SEIFERT ; H. U. WITTCHEN |Background: In a recent paper, we reported the efficacy of a modular cognitive-behavioral intervention for treating adolescents and adults with cannabis use disorders (CUD). In this study, we examine the outcome of this intervention after transl[...]Article : Périodique
C. LAPORTE ; B. PEREIRA ; O. BLANC ; B. ESCHALIER ; S. KINOUANI ; P. M. LLORCA ; G. BROUSSE ; P. VORILHON |FRANÇAIS : En 2017, un quart des français de 15 à 25 ans consommaient du cannabis mensuellement et 80 % d'entre eux ont consulté un médecin généraliste dans l'année. L'objectif de l'étude Canabic était d'évaluer l'impact d'une intervention brèv[...]Article : Périodique
C. LAPORTE ; H. VAILLANT-ROUSSEL ; B. PEREIRA ; O. BLANC ; B. ESCHALIER ; S. KINOUANI ; G. BROUSSE ; P. M. LLORCA ; P. VORILHON |PURPOSE: Brief intervention to reduce cannabis is a promising technique that could be adapted for use in primary care, but it has not been well studied in this setting. We tested the efficacy of a brief intervention conducted by general practiti[...]Périodique
C. B. CARROLL ; P. G. BAIN ; TEARE L. ; X. LIU ; JOINT C. ; WROATH C. ; S. G. PARKIN ; P. FOX ; D. WRIGHT ; J. HOBART ; J. P. ZAJICEK | 2004Background: The long-term treatment of Parkinson disease (PD) may be complicated by the development of levodopa-induced dyskinesia. Clinical and animal model data support the view that modulation of cannabinoid function may exert an antidyskinet[...]Article : Périodique
N. J. HORTON ; E. KIM ; R. SAITZ |BACKGROUND: Alcohol consumption is commonly used as a primary outcome in randomized alcohol treatment studies. The distribution of alcohol consumption is highly skewed, particularly in subjects with alcohol dependence. METHODS: In this paper, we[...]Article : Périodique
R. SAITZ ; D. M. CHENG ; M. WINTER ; T. W. KIM ; S. M. MELI ; D. ALLENSWORTH-DAVIES ; C. LLOYD-TRAVAGLINI ; J. H. SAMET |Importance: People with substance dependence have health consequences, high health care utilization, and frequent comorbidity but often receive poor-quality care. Chronic care management (CCM) has been proposed as an approach to improve care and[...]Article : Périodique
J. F. THRASHER ; M. J. CARPENTER ; J. O. ANDREWS ; K. M. GRAY ; A. J. ALBERG ; A. NAVARRO ; D. B. FRIEDMAN ; K. M. CUMMINGS |BACKGROUND: Pictorial health warning labels on cigarette packaging have been proposed for the U.S., but their potential influences among populations that suffer tobacco-related health disparities are unknown. PURPOSE: To evaluate pictorial hea[...]Article : Périodique
H. J. AUBIN ; J. REIMER ; D. J. NUTT ; A. BLADSTROM ; L. TORUP ; C. FRANÇOIS ; J. CHICK |Nalmefene is the first drug approved for reduction of alcohol consumption. The aim of this study was to evaluate the clinical relevance of treatment with nalmefene in alcohol-dependent patients with a high drinking risk level from two randomised[...]Article : Périodique
Introduction: This study examines smoke-free youth partnerships implementing the Teens Against Tobacco Use model developed by the American Lung Association. This innovative tobacco prevention strategy has not been evaluated rigorously. Students [...]Périodique
B. A. MARTELL ; F. M. ORSON ; J. POLING ; E. MITCHELL ; R. D. ROSSEN ; T. GARDNER ; T. R. KOSTEN | 2009CONTEXT. Cocaine dependence, which affects 2.5 million Americans annually, has no US Food and Drug Administration–approved pharmacotherapy. OBJECTIVES. To evaluate the immunogenicity, safety, and efficacy of a novel cocaine vaccine to treat coc[...]Article : Périodique
K. E. WATKINS ; A. J. OBER ; K. LAMP ; M. LIND ; C. SETODJI ; K. C. OSILLA ; S. B. HUNTER ; C. M. MCCULLOUGH ; K. BECKER ; P. O. IYIEWUARE ; A. DIAMANT ; K. HEINZERLING ; H. A. PINCUS |Importance: Primary care offers an important and underutilized setting to deliver treatment for opioid and/or alcohol use disorders (OAUD). Collaborative care (CC) is effective but has not been tested for OAUD. Objective: To determine whether C[...]Article : Périodique
FRANÇAIS : Position du problème : De nombreux programmes internationaux visant la réduction du tabagisme chez les jeunes sont réalisés en milieu scolaire, permettant de suivre les interventions sur plusieurs années. Les approches prometteuses p[...]Article : Périodique
AIMS: We previously reported effects of the CMCA intervention in reducing social and commercial access to alcohol by youth, and reducing alcohol use by 18-20-year-olds. This paper reports on effects of CMCA on arrests and car crashes. DESIGN: [...]Article : Périodique
A. C. WAGENAAR ; D. M. MURRAY ; J. P. GEHAN ; M. WOLFSON ; J. L. FORSTER ; T. L. TOOMEY ; C. L. PERRY ; R. JONES-WEBB |OBJECTIVE: Communities Mobilizing for Change on Alcohol (CMCA) was a randomized 15-community trial of a community organizing intervention designed to reduce the accessibility of alcoholic beverages to youths under the legal drinking age. METHO[...]Article : Périodique
BACKGROUND: Smoking cessation is a potentially appropriate role for community pharmacists because they are encouraged to advise on the correct use of nicotine replacement therapy (NRT) products and to provide behavioural support to aid smoking c[...]Périodique
H. EDER ; R. JAGSCH ; D. KRAIGHER ; A. PRIMORAC ; N. EBNER ; G. FISCHER | 2005FRANÇAIS : 64 patients recevant soit une dose moyenne de 85 mg de méthadone soit une dose moyenne de 680 mg de morphine sont évalués sur les critères de rétention en traitement, de consommation de drogues illicites (tests urinaires), de symptô[...]Article : Périodique
OBJECTIVE AND METHOD: The authors compared the effects of acetorphan, an enkephalinase inhibitor, with those of clonidine for the treatment of the opioid withdrawal syndrome. Nineteen patients addicted to heroin or synthetic opiates who were und[...]Article : Périodique
B. FRANK ; SERPELL M. G. ; J. HUGHES ; J. N. MATTHEWS ; KAPUR D. |OBJECTIVE: To compare the analgesic efficacy and side effects of the synthetic cannabinoid nabilone with those of the weak opioid dihydrocodeine for chronic neuropathic pain. DESIGN: Randomised, double blind, crossover trial of 14 weeks' duratio[...]Périodique
D. RAISTRICK ; D. WEST ; O. FINNEGAN ; G. THISTLETHWAITE ; BREARLEY R. ; J. BANBERY | 2005ENGLISH : Objective: To investigate whether a buprenorphine opiate detoxification regimen can be considered to be at least as clinically effective as a lofexidine regimen. Design: An open-label randomized controlled trial (RCT) using a non-inf[...]