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ETUDE RANDOMISEE |
Documents disponibles dans cette catégorie (219)
Article : Périodique
J. KAKKO ; K. D. SVANBORG ; M. J. KREEK ; M. HEILIG |Background: The partial opiate-receptor agonist buprenorphine has been suggested for treatment of heroin dependence, but there are few long-term and placebo-controlled studies of its effectiveness. We aimed to assess the 1-year efficacy of bupre[...]Article : Périodique
C. FARREN ; A. FARRELL ; A. HAGERTY ; C. MCHUGH |BACKGROUND AND AIMS: Alcohol use disorder (AUD) is a substantial problem, causing early death and great economic burden. Research has highlighted the potential positive impact of technological interventions, such as smartphone applications (app)[...]Article : Périodique
BACKGROUND AND AIMS: Randomized controlled trials (RCTs) are important for evaluating interventions, and qualitative research is increasingly recognized as being crucial to the success of this enterprise. We aimed to describe and demonstrate a t[...]Article : Périodique
Trends in alcohol consumption of college students remain a concern. Presented is a systematic review to determine the efficacy of alcohol-abuse interventions for college students. To be included in this review, the study must have been published[...]Article : Périodique
R. MIDFORD ; H. CAHILL ; L. LESTER ; R. RAMSDEN ; D. FOXCROFT ; L. VENNING |Aims: The Drug Education in Victorian Schools (DEVS) programme taught about licit and illicit drugs over two years (2010-2011), with follow up in the third year (2012). It focussed on minimising harm and employed participatory, critical-thinking[...]Article : Périodique
CONTEXT: Potentially effective environmental strategies have been recommended to reduce heavy alcohol use among college students. However, studies to date on environmental prevention strategies are few in number and have been limited by their no[...]Article : Périodique
G. W. JOE ; K. KNIGHT ; D. D. SIMPSON ; P. M. FLYNN ; J. T. MOREY ; N. G. BARTHOLOMEW ; M. STATON-TINDALL ; W. M. BURDON ; E. A. HALL ; S. S. MARTIN ; D. J. O'CONNELL |Finding brief effective treatments for criminal justice populations is a major public need. The CJ-DATS Targeted Intervention for Corrections (TIC), which consists of six brief interventions (communication, anger, motivation, criminal thinking, [...]Article : Périodique
Technology-based interventions such as those delivered by telephone or online may assist in removing significant barriers to treatment seeking for cannabis use disorder. Little research, however, has addressed differing technology-based treatmen[...]Article : Périodique
H. R. WHITE ; Y. JIAO ; A. E. RAY ; D. HUH ; D. C. ATKINS ; M. E. LARIMER ; K. FROMME ; W. R. CORBIN ; J. S. BAER ; J. W. LABRIE ; E. Y. MUN |Objective: This study examined whether brief motivational interventions (BMIs) designed for reducing heavy drinking among college students have secondary effects on reducing marijuana use. Method: The data came from Project INTEGRATE, which com[...]Article : Périodique
M. MEINI ; M. MONCINI ; D. CECCONI ; V. CELLESI ; L. BIASCI ; G. SIMONI ; M. AMEGLIO ; M. PELLEGRINI ; R. N. FORGIONE ; P. RUCCI |BACKGROUND: Currently, there is no specific pharmacological therapy with established efficacy for the treatment of cocaine dependence. The aim of this study was to determine the safety, tolerability and the effects of aripiprazole and ropinirole[...]Article : Périodique
ENGLISH: The Moti-4 intervention, in which motivational interviewing, self-monitoring, and strengthening behavioral control are used, was developed in the Netherlands in response to several rapid assessments of problematic use of cannabis among[...]Article : Périodique
Baclofen may reduce the symptoms of alcohol withdrawal, as an alternative or as an adjuvant for benzodiazepines, but the available data are insufficient to support baclofen-assisted alcohol withdrawal. This study investigated the need for diazep[...]Article : Périodique
Rapport
FRANÇAIS : Le baclofène, agoniste des récepteurs GABA B, est prescrit depuis 40 ans pour le traitement de la spasticité à une posologie de 30 à 80 mg par jour. Depuis 2005 de hautes doses de baclofène sont utilisées en France dans l'alcoolodépe[...]Article : Périodique
H. BRENDRYEN ; I. O. LUND ; A. B. JOHANSEN ; M. RIKSHEIM ; S. NESVAG ; F. DUCKERT |Aims: To compare a brief versus a brief plus intensive self-help version of 'Balance', a fully automated online alcohol intervention, on self-reported alcohol consumption. Design: A pragmatic randomized controlled trial. Participants in both c[...]Article : Périodique
M. SOLMI ; M. DE TOFFOL ; J. Y. KIM ; M. J. CHOI ; B. STUBBS ; T. THOMPSON ; J. FIRTH ; A. MIOLA ; G. CROATTO ; F. BAGGIO ; S. MICHELON ; L. BALLAN ; B. GERDLE ; F. MONACO ; P. SIMONATO ; P. SCOCCO ; V. RICCA ; G. CASTELLINI ; M. FORNARO ; A. MURRU ; E. VIETA ; P. FUSAR-POLI ; C. BARBUI ; J. P. A. IOANNIDIS ; A. F. CARVALHO ; J. RADUA ; C. U. CORRELL ; S. CORTESE ; R. M. MURRAY ; D. CASTLE ; J. I. SHIN ; E. DRAGIOTI |Objective: To systematically assess credibility and certainty of associations between cannabis, cannabinoids, and cannabis based medicines and human health, from observational studies and randomised controlled trials (RCTs). Design: Umbrella re[...]Article : Périodique
Objective: The purpose of the present study was to develop a treatment for marijuana dependence specifically designed to enhance self-efficacy. Method: The participants were 215 marijuana-dependent men and women randomized to one of three 9-we[...]Article : Périodique
F. J. EIROA-OROSA ; C. HAASEN ; U. VERTHEIN ; C. DILG ; I. SCHAFER ; J. REIMER |Benzodiazepine (BZD) use has been found to be associated with poorer psychosocial adjustment, higher levels of polydrug use and more risk-taking behaviors among opioid dependent patients. The aim of this paper is to analyze the correlation betwe[...]Article : Périodique
Aims College students who violate alcohol policies are often mandated to participate in alcohol-related interventions. This study investigated (i) whether such interventions reduced drinking beyond the sanction alone, (ii) whether a brief motiva[...]Périodique
A. BAKER ; N. K. LEE ; M. CLAIRE ; T. J. LEWIN ; T. GRANT ; POHLMAN S. ; J. B. SAUNDERS ; F. KAY-LAMBKIN ; CONSTABLE P. ; L. JENNER ; V. J. CARR | 2005ENGLISH : Aims : The present study sought to replicate and extend a small pilot study conducted by Baker, Boggs & Lewin (2001) which demonstrated that brief interventions consisting of motivational interviewing and cognitive-behaviour therapy [...]Article : Périodique
K. C. WINTERS ; T. FAHNHORST ; A. BOTZET ; S. LEE ; B. LALONE |This randomized controlled trial evaluated the use of two brief intervention conditions for adolescents (aged 12-18 years) who have been identified in a school setting as abusing alcohol and other drugs. Adolescents and their parents (N = 315) w[...]Périodique
M. AALTO ; SAKSANEN R. ; LAINE P. ; FORSSTROM R. ; RAIKAA M. ; KIVILUOTO M. ; K. SEPPA ; SILLANAUKEE P. | 2000BACKGROUND: Today, heavy drinking is a common health hazard among women. The evidence in favor of providing some kind of brief intervention to reduce drinking is quite convincing. However, we do not know if intervention works in a natural enviro[...]Article : Périodique
P. P. ROY-BYRNE ; K. BUMGARDNER ; A. KRUPSKI ; C. DUNN ; R. RIES ; D. M. DONOVAN ; I. I. WEST ; C. MAYNARD ; D. C. ATKINS ; M. C. GRAVES ; J. M. JOESCH ; G. A. ZARKIN |Importance: Although brief intervention is effective for reducing problem alcohol use, few data exist on its effectiveness for reducing problem drug use, a common issue in disadvantaged populations seeking care in safety-net medical settings (ho[...]Article : Périodique
S. IMTIAZ ; M. ROERECKE ; P. KURDYAK ; A. V. SAMOKHVALOV ; O. S. M. HASAN ; J. REHM |Objectives: The efficacy of brief interventions for cannabis use was assessed in a systematic review and meta-analyses. Methods: Systematic searches in academic databases were conducted, and reference lists of included studies were reviewed. Ra[...]Article : Périodique
OBJECTIVE: Alcohol-impaired (AI) driving among college students remains a significant public health concern and may be the single most risky drinking outcome among young adults. Brief motivational interventions (BMIs) have been shown to reduce a[...]Article : Périodique
J. BERNSTEIN ; T. HEEREN ; E. EDWARD ; D. DORFMAN ; C. BLISS ; M. WINTER ; E. BERNSTEIN |OBJECTIVES: Adolescents in their late teens and early 20s have the highest alcohol consumption in the United States; binge drinking peaks at age 21-25 years. Underage drinking is associated with many negative consequences, including academic pro[...]Article : Périodique
CONTEXT: Selective interventions targeting personality risk are showing promise in the prevention of problematic drinking behavior, but their effect on illicit drug use has yet to be evaluated. OBJECTIVE: To investigate the efficacy of targete[...]Article : Périodique
T. CARNEY ; B. J. MYERS ; J. LOUW ; C. I. OKWUNDU |BACKGROUND: Adolescent substance use is a major problem in and of itself, and because it acts as a risk factor for other problem behaviours. As substance use during adolescence can lead to adverse and often long-term health and social consequenc[...]Article : Périodique
R. N. ROSENTHAL ; W. LING ; P. CASADONTE ; F. VOCCI ; G. L. BAILEY ; K. KAMPMAN ; A. A. PATKAR ; S. CHAVOUSTIE ; C. BLASEY ; S. C. SIGMON ; K. L. BEEBE |Aims: To evaluate the safety and efficacy of buprenorphine implants (BI) versus placebo implants (PI) for the treatment of opioid dependence. A secondary aim compared BI to open-label sublingual buprenorphine/naloxone tablets (BNX). Design: Ran[...]Article : Périodique
W. LING ; P. CASADONTE ; G. BIGELOW ; K. M. KAMPMAN ; A. A. PATKAR ; G. L. BAILEY ; R. N. ROSENTHAL ; K. L. BEEBE |Context: Limitations of existing pharmacological treatments for opioid dependence include low adherence, medication diversion, and emergence of withdrawal symptoms. Objective: To determine the efficacy of buprenorphine implants that provide a l[...]Article : Périodique
Aims: To examine the effectiveness of a personality-targeted intervention program (Adventure trial) delivered by trained teachers to high-risk (HR) high-school students on reducing marijuana use and frequency of use. Design: A cluster-randomize[...]Article : Périodique
E. HOCH ; G. BÜHRINGER ; A. PIXA ; K. DITTMER ; J. HENKER ; A. SEIFERT ; H. U. WITTCHEN |Background: In a recent paper, we reported the efficacy of a modular cognitive-behavioral intervention for treating adolescents and adults with cannabis use disorders (CUD). In this study, we examine the outcome of this intervention after transl[...]Article : Périodique
C. LAPORTE ; B. PEREIRA ; O. BLANC ; B. ESCHALIER ; S. KINOUANI ; P. M. LLORCA ; G. BROUSSE ; P. VORILHON |FRANÇAIS : En 2017, un quart des français de 15 à 25 ans consommaient du cannabis mensuellement et 80 % d'entre eux ont consulté un médecin généraliste dans l'année. L'objectif de l'étude Canabic était d'évaluer l'impact d'une intervention brèv[...]Article : Périodique
C. LAPORTE ; H. VAILLANT-ROUSSEL ; B. PEREIRA ; O. BLANC ; B. ESCHALIER ; S. KINOUANI ; G. BROUSSE ; P. M. LLORCA ; P. VORILHON |PURPOSE: Brief intervention to reduce cannabis is a promising technique that could be adapted for use in primary care, but it has not been well studied in this setting. We tested the efficacy of a brief intervention conducted by general practiti[...]Périodique
C. B. CARROLL ; P. G. BAIN ; TEARE L. ; X. LIU ; JOINT C. ; WROATH C. ; S. G. PARKIN ; P. FOX ; D. WRIGHT ; J. HOBART ; J. P. ZAJICEK | 2004Background: The long-term treatment of Parkinson disease (PD) may be complicated by the development of levodopa-induced dyskinesia. Clinical and animal model data support the view that modulation of cannabinoid function may exert an antidyskinet[...]Article : Périodique
N. J. HORTON ; E. KIM ; R. SAITZ |BACKGROUND: Alcohol consumption is commonly used as a primary outcome in randomized alcohol treatment studies. The distribution of alcohol consumption is highly skewed, particularly in subjects with alcohol dependence. METHODS: In this paper, we[...]Article : Périodique
R. SAITZ ; D. M. CHENG ; M. WINTER ; T. W. KIM ; S. M. MELI ; D. ALLENSWORTH-DAVIES ; C. LLOYD-TRAVAGLINI ; J. H. SAMET |Importance: People with substance dependence have health consequences, high health care utilization, and frequent comorbidity but often receive poor-quality care. Chronic care management (CCM) has been proposed as an approach to improve care and[...]Article : Périodique
J. F. THRASHER ; M. J. CARPENTER ; J. O. ANDREWS ; K. M. GRAY ; A. J. ALBERG ; A. NAVARRO ; D. B. FRIEDMAN ; K. M. CUMMINGS |BACKGROUND: Pictorial health warning labels on cigarette packaging have been proposed for the U.S., but their potential influences among populations that suffer tobacco-related health disparities are unknown. PURPOSE: To evaluate pictorial hea[...]Article : Périodique
H. J. AUBIN ; J. REIMER ; D. J. NUTT ; A. BLADSTROM ; L. TORUP ; C. FRANÇOIS ; J. CHICK |Nalmefene is the first drug approved for reduction of alcohol consumption. The aim of this study was to evaluate the clinical relevance of treatment with nalmefene in alcohol-dependent patients with a high drinking risk level from two randomised[...]Article : Périodique
Introduction: This study examines smoke-free youth partnerships implementing the Teens Against Tobacco Use model developed by the American Lung Association. This innovative tobacco prevention strategy has not been evaluated rigorously. Students [...]Périodique
B. A. MARTELL ; F. M. ORSON ; J. POLING ; E. MITCHELL ; R. D. ROSSEN ; T. GARDNER ; T. R. KOSTEN | 2009CONTEXT. Cocaine dependence, which affects 2.5 million Americans annually, has no US Food and Drug Administration–approved pharmacotherapy. OBJECTIVES. To evaluate the immunogenicity, safety, and efficacy of a novel cocaine vaccine to treat coc[...]Article : Périodique
K. E. WATKINS ; A. J. OBER ; K. LAMP ; M. LIND ; C. SETODJI ; K. C. OSILLA ; S. B. HUNTER ; C. M. MCCULLOUGH ; K. BECKER ; P. O. IYIEWUARE ; A. DIAMANT ; K. HEINZERLING ; H. A. PINCUS |Importance: Primary care offers an important and underutilized setting to deliver treatment for opioid and/or alcohol use disorders (OAUD). Collaborative care (CC) is effective but has not been tested for OAUD. Objective: To determine whether C[...]Article : Périodique
FRANÇAIS : Position du problème : De nombreux programmes internationaux visant la réduction du tabagisme chez les jeunes sont réalisés en milieu scolaire, permettant de suivre les interventions sur plusieurs années. Les approches prometteuses p[...]Article : Périodique
AIMS: We previously reported effects of the CMCA intervention in reducing social and commercial access to alcohol by youth, and reducing alcohol use by 18-20-year-olds. This paper reports on effects of CMCA on arrests and car crashes. DESIGN: [...]Article : Périodique
A. C. WAGENAAR ; D. M. MURRAY ; J. P. GEHAN ; M. WOLFSON ; J. L. FORSTER ; T. L. TOOMEY ; C. L. PERRY ; R. JONES-WEBB |OBJECTIVE: Communities Mobilizing for Change on Alcohol (CMCA) was a randomized 15-community trial of a community organizing intervention designed to reduce the accessibility of alcoholic beverages to youths under the legal drinking age. METHO[...]Article : Périodique
BACKGROUND: Smoking cessation is a potentially appropriate role for community pharmacists because they are encouraged to advise on the correct use of nicotine replacement therapy (NRT) products and to provide behavioural support to aid smoking c[...]Périodique
H. EDER ; R. JAGSCH ; D. KRAIGHER ; A. PRIMORAC ; N. EBNER ; G. FISCHER | 2005FRANÇAIS : 64 patients recevant soit une dose moyenne de 85 mg de méthadone soit une dose moyenne de 680 mg de morphine sont évalués sur les critères de rétention en traitement, de consommation de drogues illicites (tests urinaires), de symptô[...]Article : Périodique
OBJECTIVE AND METHOD: The authors compared the effects of acetorphan, an enkephalinase inhibitor, with those of clonidine for the treatment of the opioid withdrawal syndrome. Nineteen patients addicted to heroin or synthetic opiates who were und[...]Article : Périodique
B. FRANK ; SERPELL M. G. ; J. HUGHES ; J. N. MATTHEWS ; KAPUR D. |OBJECTIVE: To compare the analgesic efficacy and side effects of the synthetic cannabinoid nabilone with those of the weak opioid dihydrocodeine for chronic neuropathic pain. DESIGN: Randomised, double blind, crossover trial of 14 weeks' duratio[...]Périodique
D. RAISTRICK ; D. WEST ; O. FINNEGAN ; G. THISTLETHWAITE ; BREARLEY R. ; J. BANBERY | 2005ENGLISH : Objective: To investigate whether a buprenorphine opiate detoxification regimen can be considered to be at least as clinically effective as a lofexidine regimen. Design: An open-label randomized controlled trial (RCT) using a non-inf[...]