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What's in that pill ? / SAYWELL T.
Titre : What's in that pill ? Type de document : Périodique Auteurs : SAYWELL T. ; J. McMANUS Année de publication : 2002 Importance : 34-39 Présentation : ill. Note générale : Far Eastern Economic Review, 2002, 34-39 Langues : Français (fre) Mots-clés : Thésaurus TOXIBASE
MEDICAMENTS ; USAGE DETOURNE ; TRAFIC ; SANTE PUBLIQUE
Discipline : SAN Santé publique / Public health Note de contenu : ill. Domaine : Autres substances / Other substances Affiliation : Etats-Unis. United States. Centre Emetteur : 13 OFDT Cote : A00838 Permalink : When "chems" meet sex: A rising phenomenon called "chemsex" / R. GIORGETTI ; A. TAGLIABRACCI ; F. SCHIFANO ; S. ZAAMI ; E. MARINELLI ; F. P. BUSARDO in Current Neuropharmacology, Vol.15, n°5 (2017)
Titre : When "chems" meet sex: A rising phenomenon called "chemsex" Type de document : Périodique Auteurs : R. GIORGETTI ; A. TAGLIABRACCI ; F. SCHIFANO ; S. ZAAMI ; E. MARINELLI ; F. P. BUSARDO Année de publication : 2017 Article en page(s) : 762-770 Langues : Anglais (eng) Mots-clés : Thésaurus TOXIBASE
ACTIVITE SEXUELLE ; DROGUES DE SYNTHESE ; GHB ; MEPHEDRONE ; METHAMPHETAMINE ; POPPERS ; HOMOSEXUEL ; TOXICITE ; MECANISME D'ACTION ; MEDICAMENTS ; PHARMACOLOGIE ; VOIE D'ADMINISTRATION ; SILDENAFIL ; PHENOMENE EMERGENT
Mots-clés : chemsex Discipline : PRO Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods Résumé : Background: The term "chemsex" was coined to indicate the voluntary intake of psychoactive and non psychoactive drugs in the context of recreational settings to facilitate and/or to enhance sexual intercourses mostly among men who have sex with other men (MSM).
Objective: The authors aimed to review the mechanisms of action, the toxicity and the pattern of use and abuse of substances involved in "chemsex" practice together with the sociocultural background underlying it and the health-related consequences that they may have.
Results: Gamma-hydroxybutyrate, gamma-butyrolactone,1,4-butanediol, mephedrone, methamphetamine, sildenafil, tadalafil, vardenafil and alkyl nitrites have been described in their role of "chemsex drugs" including pharmacological action and in their implication to impair capacities to chose sexual partners and consensual sex. Moreover, it has been demonstrated that sexual activity over protracted length of time under the influence of chemsex drugs can result in rectal trauma or penile abrasions and a significant increase of the risk of transmission of sexual transmitted diseases, especially in case of condomless intercourses, which are frequent in this context, representing therefore a serious health threat.
Conclusion: One of the major problems to establish health policy priority interventions for chemsex is the lack of available epidemiological data on the issue. Finally, social actions should be taken in order to break down the barriers that currently exist among chemsex drug users in accessing services, including the shame and stigma often associated with drug use. In conclusion, more specific resources to face high risks of infections and HIV transmission are required in bisexual and homosexual individuals having SUID: sex under the influence of drugs.
Domaine : Autres substances / Other substances ; Drogues illicites / Illicit drugs Sous-type de document : Revue de la littérature / Literature review Refs biblio. : 58 Affiliation : Section of Legal Medicine, Università Politecnica delle Marche, Ancona, Italy Permalink :
in Current Neuropharmacology > Vol.15, n°5 (2017) . - 762-770[article]When 'drugs' become 'drugs': Issues of pharmaceutical abuse in France from the 1960s to the 1990s / A. MARCHANT in Medicina nei Secoli, Arte e Scienza, Vol.26, n°2 (2014)
Titre : When 'drugs' become 'drugs': Issues of pharmaceutical abuse in France from the 1960s to the 1990s Type de document : Périodique Auteurs : A. MARCHANT Année de publication : 2014 Article en page(s) : 575-614 Langues : Anglais (eng) Italien (ita) Mots-clés : Thésaurus Géographique
HISTOIRE ; MEDICAMENTS ; ABUS ; PRODUIT ILLICITE ; POLYCONSOMMATION ; HEROINE ; PSYCHOTROPES ; USAGE DETOURNE ; SUBSTITUTION ; CODEINE ; MEDECIN ; PHARMACIEN
Discipline : SHS Sciences humaines et sociales / Human and social sciences Résumé : Since the 1970s, media frenzies about drug addiction have focused mainly on illicit drugs taken by rebellious or marginalised addicts, relegating iatrogenic drug abuse, and policies and problems linked to psychotropic pharmaceuticals available by prescription or over-the-counter to the shadows. In this article I go beyond the division between illicit drugs and medicines still configuring both public representations and historiography: using archival materials from the 1960s-1990s in France, I highlight some blind spots in drug history. Firstly I demonstrate the role of pharmaceutical abuse in the career of addicts, and then examine regulation policies, which are the dark side, however complementary, of drug policies and prohibition. Finally, I analyse the role of physicians and pharmacists in this control, and discuss the various professional debates relating to the legal supply of psychoactive drugs. In all these issues, the frame of the Cold War context will also be highlighted. Domaine : Autres substances / Other substances ; Drogues illicites / Illicit drugs Refs biblio. : 69 Affiliation : ENS Cachan, Institut des sciences sociales du Politique, France Permalink :
in Medicina nei Secoli, Arte e Scienza > Vol.26, n°2 (2014) . - 575-614[article]Which drugs cause overdose among opiate misusers ? Study of personal and witnessed overdoses / J. STRANG
Titre : Which drugs cause overdose among opiate misusers ? Study of personal and witnessed overdoses Titre traduit : (Quelles drogues entraînent des overdoses chez les usagers d'opiacés ? Etude réalisée auprès d'individus et de témoins) Type de document : Périodique Auteurs : J. STRANG ; P. GRIFFITHS ; POWIS B. ; J. FOUNTAIN ; S. WILLIAMSON ; M. GOSSOP Année de publication : 1999 Importance : 253-261 Présentation : fig., tabl. Note générale : Drug and Alcohol Review, 1999, 18, (3), 253-261 Langues : Anglais (eng) Mots-clés : Thésaurus TOXIBASE
OPIACES ; METHADONE ; HEROINE ; MEDICAMENTS ; INTERACTION CHIMIQUE ; SURDOSE ; MORTALITE
Résumé : FRANÇAIS :
Les larges prescriptions de méthadone en Angleterre conduisent à s'interroger sur sa toxicité et les risques d'overdose. L'étude porte sur 312 toxicomanes par voie intraveineuse, et concerne les overdoses fatales et non fatales. L'héroïne est la drogue la plus souvent impliquée dans les overdoses (>80%), dans les trois régions étudiées. La méthadone est responsable de la moitié des autres overdoses aux opiacés. Les associations sont fréquentes : héroïne plus méthadone ou héroïne plus non-opiacés.
Concern has been expressed at the widespread prescribing of methadone in view of its inherent toxicity. Commentators have opined that methadone is more toxic than heroin and causes more overdose deaths. However, data deficiencies and flawed analyses leave continuing uncertainty about this crucial policy issue. The relative contributions of heroin, other opiates (e.g. methadone) and non-opiate drugs to overdose and overdose deaths among drug misusers were examined in a community-recruited sample of 312 injecting drug misusers in London. Data were collected on last personal overdose (n = 117), last witnessed overdose (n = 167) and last witnessed fatal overdose (n = 55), and on the different drugs that had been involved with these overdoses. Heroin was involved in 83% of last personal overdoses, 90% of last witnessed overdoses and 80% of last witnessed fatal overdoses, while other opiates were involved in only 18%, 8% and 26%, respectively. Methadone accounted for about half of these "other opiate" overdoses. Overdoses involving a combination of heroin and a non-opiate were common-29%, 21% and 39%, respectively. Heroin was the drug most frequently involved in overdose across all 1hree areas of study. However, combinations of heroin and a non-opiate were surprisingly frequent, especially in witnessed fatal overdoses (as reported recently by other investigators using different methodologies). Considering the wide extent of methadone prescribing to this group, methadone was remarkably infrequently reported as responsible (solely or in combination) for either personal overdoses, (Author's abstract.)
Note de contenu : fig., tabl. Domaine : Drogues illicites / Illicit drugs Refs biblio. : 35 Affiliation : Nal Addict. Ctr, Inst. Psychiatr., Denmark Hill, London
Royaume-Uni. United Kingdom.
Numéro Toxibase : 803021 Centre Emetteur : 08 CAS Strasbourg Permalink : Which indicators can public health authorities use to monitor prescription drug abuse and evaluate the impact of regulatory measures? Controlling High Dosage Buprenorphine abuse / V. PAULY ; E. FRAUGER ; V. PRADEL ; F. ROUBY ; J. BERBIS ; F. NATALI ; P. REGGIO ; H. COUDERT ; J. MICALLEF ; X. THIRION in Drug and Alcohol Dependence, Vol.113, n°1 (January 2011)
Titre : Which indicators can public health authorities use to monitor prescription drug abuse and evaluate the impact of regulatory measures? Controlling High Dosage Buprenorphine abuse Type de document : Périodique Auteurs : V. PAULY ; E. FRAUGER ; V. PRADEL ; F. ROUBY ; J. BERBIS ; F. NATALI ; P. REGGIO ; H. COUDERT ; J. MICALLEF ; X. THIRION Année de publication : 2011 Article en page(s) : 29-36 Langues : Anglais (eng) Mots-clés : Thésaurus Géographique
SANTE PUBLIQUE ; BUPRENORPHINE ; MEDICAMENTS ; ABUS ; REMBOURSEMENT SS ; BASE DE DONNEES ; EPIDEMIOLOGIE DESCRIPTIVE ; MEDECIN GENERALISTE ; USAGE DETOURNE ; PRESCRIPTION MEDICALE ; METHODE
Discipline : EPI Epidémiologie / Epidemiology Résumé : Background: Two methods have been recently developed from a drug reimbursement database to provide useful indicators for public health authorities concerning the abuse potential of psychotropic drugs. The doctor-shopping indicator (DSI) measures the proportion of the drug obtained by doctor shopping among the overall quantity of the drug reimbursed and the clustering method reveals subgroups of deviant patients.
Objective: The objective of the study was to analyze and compare indicators resulting from these two methods, applied to High Dosage Buprenorphine (HDB) (a product well-known to be diverted in France), in order to determine which public health authorities needs they answer.
Data analysis: The patients with reimbursed HDB were grouped using the clustering method in terms of drug dispensations characteristics over a nine month period. The characteristics of the resulting subgroups, including their DSI, were then compared.
Results: 4787 Patients (73.4%) had no measurable doctor-shopping behaviour. But the comparison of the two methods demonstrated that the more a patient's profile was characterized by deviant behavior, the higher was the DSI: from 0.4% in a subgroup with a median profile to 72% in a subgroup with a deviant profile.
Conclusion: These two methods are useful surveillance tools for public health authorities: the clustering method may help devise pertinent intervention strategies to reduce prescription drug abuse while the DSI method provides quantitative information demonstrating whether these strategies are useful. We discuss the advantages and disadvantages of using these two methods as useful indicators for public health authorities. [Author's abstract]
Domaine : Autres substances / Other substances Affiliation : Centre d'Evaluation et d'Information sur la Pharmacodépendance (CEIP), Centre Associé, Laboratoire de Santé Publique, Faculté de médecine, Marseille, France Permalink :
in Drug and Alcohol Dependence > Vol.113, n°1 (January 2011) . - 29-36[article]Which psychoactive prescription drugs are illegally obtained and through which ways of acquisition? About OPPIDUM survey / E. FRAUGER ; S. NORDMANN ; V. ORLÉANS ; V. PRADEL ; V. PAULY ; X. THIRION ; J. MICALLEF ; Réseau des CEIP in Fundamental and Clinical Pharmacology, Vol.26, n°4 (August 2012)PermalinkWhich psychoactive substances are used by patients seen in the healthcare system in French overseas territories? Results of the OPPIDUM survey / A. DAVELUY ; E. FRAUGER ; H. PEYRIÈRE ; C. MORACCHINI ; F. HARAMBURU ; J. MICALLEF in Fundamental and Clinical Pharmacology, Vol.31, n°1 (February 2017)PermalinkWHO's role, mandate and activities to counter the world drug problem. A public health perspective / OMS / WHOPermalinkWho sells what? Country specific differences in substance availability on the Agora cryptomarket / J. VAN BUSKIRK ; S. NAICKER ; A. ROXBURGH ; R. BRUNO ; L. BURNS in International Journal of Drug Policy, Vol.35 (September 2016)PermalinkWhy do some doctors become addicted? [Editorial] / D. BROOKE in Addiction, Vol.91, n°3 (March 1996)PermalinkWhy low-dose benzodiazepine-dependent insomniacs can't escape their sleeping pills / D. SCHNEIDER-HELMERT in Acta Psychiatrica Scandinavica, Vol.78, n°6 (December 1988)PermalinkWomen and substance abuse problems / R. A. CORMIER ; C. A. DELL ; N. POOLE in BMC Women's Health, Vol.4, Suppl.1 (2004)PermalinkWomen as home caregivers : gender portrayal in OTC drug commercials / R. S. CRAIGPermalinkWorkshop on the medical utility of marijuana / ***PermalinkWorldwide prevalence and trends in unintentional drug overdose: A systematic review of the literature / S. S. MARTINS ; L. SAMPSON ; M. CERDA ; S. GALEA in American Journal of Public Health, Vol.105, n°11 (November 2015)Permalink