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Titre :	Vol.39, n°2 - 3 December 2012 - New drugs of abuse
Type de document :	Périodique
Auteurs :	C. DAVIDSON, Editeur scientifique
Année de publication :	2012
Langues :	Anglais
Permalink :	https://bdoc.ofdt.fr/index.php?lvl=bulletin_display&id=5373

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New psychoactive substances [Editorial] / C. DAVIDSON in Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol.39, n°2 (3 December 2012)

Identifying emerging trends in recreational drug use; outcomes from the Psychonaut Web Mapping Project / P. DELUCA ; Z. DAVEY ; O. CORAZZA ; L. DI FURIA ; M. FARRE ; L. H. FLESLAND ; M. MANNONEN ; A. MAJAVA ; T. PELTONIEMI ; M. PASINETTI ; C. PEZZOLESI ; N. SCHERBAUM ; H. SIEMANN ; A. SKUTLE ; M. TORRENS ; P. VAN DER KREEFT ; E. IVERSEN ; F. SCHIFANO in Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol.39, n°2 (3 December 2012)

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in Progress in Neuro-Psychopharmacology and Biological Psychiatry > Vol.39, n°2 (3 December 2012) . - 221-226

Titre :	Identifying emerging trends in recreational drug use; outcomes from the Psychonaut Web Mapping Project
Type de document :	Périodique
Auteurs :	P. DELUCA ; Z. DAVEY ; O. CORAZZA ; L. DI FURIA ; M. FARRE ; L. H. FLESLAND ; M. MANNONEN ; A. MAJAVA ; T. PELTONIEMI ; M. PASINETTI ; C. PEZZOLESI ; N. SCHERBAUM ; H. SIEMANN ; A. SKUTLE ; M. TORRENS ; P. VAN DER KREEFT ; E. IVERSEN ; F. SCHIFANO
Année de publication :	2012
Article en page(s) :	221-226
Note générale :	Note de police scientifique : Revue Internationale de Criminologie et de Police Technique et Scientifique 2015;68(2):252-253.
Langues :	Anglais
Mots-clés :	Thésaurus Géographique EUROPE Thésaurus TOXIBASE INTERNET ; DROGUES DE SYNTHESE ; PHENOMENE EMERGENT ; USAGE RECREATIF ; SURVEILLANCE EPIDEMIOLOGIQUE
Discipline :	PRO Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods
Domaine :	Drogues illicites / Illicit drugs
Résumé :	BACKGROUND: This paper presents the outcomes of the 2-year European Union funded Psychonaut Web Mapping Project which aimed at developing and implementing an integrated web mapping system to promptly identify and learn about novel psychoactive substances (NPS; "legal highs") through the regular monitoring of the Internet. METHODS: More than 200 discussion forums, social media, online shops, websites and other Internet resources (e.g. YouTube, eBay, Google, Google Insight) have been extensively and regularly monitored in 7 European countries (UK, Finland, Norway, Belgium, Germany, Italy and Spain) for emerging trends of NPS throughout the period of the study. RESULTS: Key online resources have been identified as "leading edge" which have provided accurate and timely information on novel emerging compounds. In total more than 400 substances/products have been recorded. NPS have been noted online before reaching wider audiences. DISCUSSION: Although a high number of novel psychoactive substances have been identified in the 2-year duration of the project, not all have become trends that needed public health response. Conversely, new recreational drug phenomena such as "spice drugs," mephedrone and naphyrone were all identified as emerging trends in forums and websites. In addition, it has been possible for the first time to collate detailed information on these and several more compounds even though no or limited scientific publications were available. It is therefore recommended that these monitoring activities are to be continued, that more countries, researchers and health professionals are involved, and that the findings are widely shared with all the relevant agencies, health professionals and future research projects. Implications, advantages and limitations of using the Internet as primary source for identifying emerging trends are also discussed.
Affiliation :	National Addiction Centre, Institute of Psychiatry, King's College London, London, UK
Permalink :	https://bdoc.ofdt.fr/index.php?lvl=notice_display&id=72171

Mephedrone (4-methylmethcathinone): what is new in our understanding of its use and toxicity / D. M. WOOD ; P. I. DARGAN in Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol.39, n°2 (3 December 2012)

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in Progress in Neuro-Psychopharmacology and Biological Psychiatry > Vol.39, n°2 (3 December 2012) . - 227-233

Titre :	Mephedrone (4-methylmethcathinone): what is new in our understanding of its use and toxicity
Type de document :	Périodique
Auteurs :	D. M. WOOD ; P. I. DARGAN
Année de publication :	2012
Article en page(s) :	227-233
Langues :	Anglais
Mots-clés :	Thésaurus TOXIBASE MEPHEDRONE ; TOXICITE ; DROGUES DE SYNTHESE ; ANALYSE CHIMIQUE ; PREVALENCE
Discipline :	PRO Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods
Domaine :	Drogues illicites / Illicit drugs
Résumé :	Mephedrone (4-methylmethcathinone) is a synthetic cathinone that has been used as a recreational drug in Europe and elsewhere in the world since 2007. In addition to published scientific papers there are a number of different data sources available which provide information on the sources, availability and prevalence of use of mephedrone. Whilst there are no formal human studies to determine the acute toxicity of mephedrone, there is a range of different levels of data available which describe the acute toxicity of mephedrone. These include user Internet discussion fora, sub-population level surveys of user previous experiences of acute toxicity and individual case reports and case series of toxicity related to both self-reported and analytically confirmed mephedrone use. In this review article we describe how through the process of data triangulation using a combination of these different sources, it is possible to develop an understanding of the acute toxicity of mephedrone. This demonstrates that mephedrone has a pattern of acute toxicity that is similar to other stimulant drugs such as MDMA, amphetamine and cocaine.
Sous-type de document :	Revue de la littérature / Literature review
Affiliation :	Guy's and St Thomas' NHS Foundation Trust, London, UK
Permalink :	https://bdoc.ofdt.fr/index.php?lvl=notice_display&id=72172

Spice drugs are more than harmless herbal blends: a review of the pharmacology and toxicology of synthetic cannabinoids / K. A. SEELY ; J. LAPOINT ; J. H. MORAN ; L. FATTORE in Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol.39, n°2 (3 December 2012)

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in Progress in Neuro-Psychopharmacology and Biological Psychiatry > Vol.39, n°2 (3 December 2012) . - 234-243

Titre :	Spice drugs are more than harmless herbal blends: a review of the pharmacology and toxicology of synthetic cannabinoids
Type de document :	Périodique
Auteurs :	K. A. SEELY ; J. LAPOINT ; J. H. MORAN ; L. FATTORE
Année de publication :	2012
Article en page(s) :	234-243
Langues :	Anglais
Mots-clés :	Thésaurus TOXIBASE CANNABINOIDES ; PHARMACOLOGIE ; TOXICOLOGIE ; DROGUES DE SYNTHESE ; ANALYSE CHIMIQUE ; LEGISLATION ; PHYSIOLOGIE ; MECANISME D'ACTION ; EFFET SECONDAIRE
Discipline :	PRO Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods
Domaine :	Drogues illicites / Illicit drugs
Résumé :	"K2" and "Spice" drugs (collectively hereafter referred to as Spice) represent a relatively new class of designer drugs that have recently emerged as popular alternatives to marijuana, otherwise characterized as "legal highs". These drugs are readily available on the Internet and sold in many head shops and convenience stores under the disguise of innocuous products like herbal blends, incense, or air fresheners. Although package labels indicate "not for human consumption", the number of intoxicated people presenting to emergency departments is dramatically increasing. The lack of validated and standardized human testing procedures and an endless supply of potential drugs of abuse are primary reasons why researchers find it difficult to fully characterize clinical consequences associated with Spice. While the exact chemical composition and toxicology of Spice remains to be determined, there is mounting evidence identifying several synthetic cannabinoids as causative agents responsible for psychoactive and adverse physical effects. This review provides updates of the legal status of common synthetic cannabinoids detected in Spice and analytical procedures used to test Spice products and human specimens collected under a variety of clinical circumstances. The pharmacological and toxicological consequences of synthetic cannabinoid abuse are also reviewed to provide a future perspective on potential short- and long-term implications. HIGHLIGHTS: • Synthetic cannabinoids (spice) recently emerged as popular alternatives to marijuana. • Spice chemical composition and toxicology remains to be determined. • An update of the legal status of synthetic cannabinoids commonly detected is provided. • We describe analytical testing procedures for their identification in herbal blends and human specimens. • The pharmacological and toxicological effects of synthetic cannabinoids are discussed.
Sous-type de document :	Revue de la littérature / Literature review
Affiliation :	Arkansas Department of Health, Public Health Laboratory, Little Rock, AR, USA
Permalink :	https://bdoc.ofdt.fr/index.php?lvl=notice_display&id=72173

Cardiovascular toxicity of novel psychoactive drugs: Lessons from the past / P. DAWSON ; J. D. MOFFATT in Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol.39, n°2 (3 December 2012)

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in Progress in Neuro-Psychopharmacology and Biological Psychiatry > Vol.39, n°2 (3 December 2012) . - 244-252

Titre :	Cardiovascular toxicity of novel psychoactive drugs: Lessons from the past
Type de document :	Périodique
Auteurs :	P. DAWSON ; J. D. MOFFATT
Année de publication :	2012
Article en page(s) :	244-252
Langues :	Anglais
Mots-clés :	Thésaurus TOXIBASE DROGUES DE SYNTHESE ; APPAREIL CARDIOVASCULAIRE ; MORBIDITE ; MORTALITE ; PHARMACOLOGIE ; SEROTONINE ; EVOLUTION ; ECSTASY ; MEPHEDRONE ; DOPAMINE ; VASOCONSTRICTION ; CATECHOLAMINES ; BRONCHODILATATEURS ; AMPHETAMINES
Discipline :	PRO Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods
Domaine :	Drogues illicites / Illicit drugs
Résumé :	The long use of ephedrine, amphetamines, cocaine, LSD and more recently 3,4-methylenedioxy-N-methylamphetamine (MDMA; “Ecstasy”) allows us to predict with some confidence what cardiovascular risks are likely to be associated with novel psychoactive substances (NPS). Once the probably multiple biological activities of a compound are known it is possible to define the likely risks of cardiovascular toxicity. Agonists of 5-HT2A receptors or alpha-adrenoceptors may cause vasoconstriction and tissue ischemia. Drugs which have agonist affinity for 5-HT2B receptors will probably promote heart valve fibrosis leading to heart failure. Compounds that interfere with uptake of dopamine or 5-hydroxytryptamine (5-HT) are likely to also have effects on noradrenergic neurotransmission and lead to sympathomimetic effects on the heart and vasculature. Drugs that cause dopamine release, or inhibit uptake are likely to be addictive and lead to chronic use. Other drugs (particularly the so-called empathogens) are associated with weekly usage in social settings; over time such use can lead to cardiovascular harm. Defining which of these effects NPS have is an important element of predicting the harm they may cause and informing those appointed to introduce regulations to control them. HIGHLIGHTS: • We review the recent history of psychoactive drug abuse. • We describe the associations between drugs of abuse and cardiovascular toxicity. • We highlight potential risks associated with novel psychoactive substances.
Sous-type de document :	Revue de la littérature / Literature review
Affiliation :	Division of Biomedical Sciences, St. George's, University of London, London, UK
Permalink :	https://bdoc.ofdt.fr/index.php?lvl=notice_display&id=72174

2-DPMP (desoxypipradrol, 2-benzhydrylpiperidine, 2-phenylmethylpiperidine) and D2PM (diphenyl-2-pyrrolidin-2-yl-methanol, diphenylprolinol): A preliminary review / J. M. CORKERY ; S. ELLIOTT ; F. SCHIFANO ; O. CORAZZA ; A. H. GHODSE in Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol.39, n°2 (3 December 2012)

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in Progress in Neuro-Psychopharmacology and Biological Psychiatry > Vol.39, n°2 (3 December 2012) . - 253-258

Titre :	2-DPMP (desoxypipradrol, 2-benzhydrylpiperidine, 2-phenylmethylpiperidine) and D2PM (diphenyl-2-pyrrolidin-2-yl-methanol, diphenylprolinol): A preliminary review
Type de document :	Périodique
Auteurs :	J. M. CORKERY ; S. ELLIOTT ; F. SCHIFANO ; O. CORAZZA ; A. H. GHODSE
Année de publication :	2012
Article en page(s) :	253-258
Langues :	Anglais
Mots-clés :	Thésaurus TOXIBASE DROGUES DE SYNTHESE ; USAGE RECREATIF ; TOXICITE ; ANALYSE CHIMIQUE ; TYPE D'USAGE ; PHARMACOLOGIE ; EFFET SECONDAIRE
Discipline :	PRO Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods
Domaine :	Drogues illicites / Illicit drugs
Résumé :	2-DPMP (desoxypipradrol, 2-benzhydrylpiperidine, 2-phenylmethylpiperidine) and D2PM (diphenyl-2-pyrrolidin-2-yl-methanol, diphenylprolinol) are psychoactive substances, sold primarily over the Internet and in 'head' shops as 'legal highs', 'research chemicals' or 'plant food'. Originally developed in the 1950s for the treatment of narcolepsy and ADHD, 2-DPMP's use soon became very limited. Recreational use of 2-DPMP and D2PM appears to have started in March 2007, but only developed slowly. However, in the UK their popularity grew in 2009, increasing rapidly during summer 2010. At this time, there were many presentations to UK Emergency Departments by patients complaining of undesirable physical and psychiatric effects after taking 2-DPMP. In spring 2011 there were similar presentations for D2PM. Recreational use of these drugs has been reported only occasionally in on-line user fora. There is little scientifically-based literature on the pharmacological, physiological, psychopharmacological, toxicological and epidemiological characteristics of these drugs. Here we describe what is known about them, especially on their toxicity, including what we believe to be the first three deaths involving the use of 2-DPMP in August 2010. There are no international controls imposed on 2-DPMP or D2PM. However, a ban on their UK importation was imposed in November 2011 and they became Class C drugs on 13 June 2012. It is critical that any other cases, including non-fatal overdoses, are documented so that a scientific evidence-base can be established for them.
Sous-type de document :	Revue de la littérature / Literature review
Affiliation :	National Programme for Substance Abuse Deaths (np-SAD), International Centre for Drug Policy, St. George's, University of London, London, UK
Permalink :	https://bdoc.ofdt.fr/index.php?lvl=notice_display&id=72175

The recreational tryptamine 5-MeO-DALT (N,N-diallyl-5-methoxytryptamine): A brief review / J. M. CORKERY ; E. DURKIN ; S. ELLIOTT ; F. SCHIFANO ; A. H. GHODSE in Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol.39, n°2 (3 December 2012)

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in Progress in Neuro-Psychopharmacology and Biological Psychiatry > Vol.39, n°2 (3 December 2012) . - 259-262

Titre :	The recreational tryptamine 5-MeO-DALT (N,N-diallyl-5-methoxytryptamine): A brief review
Type de document :	Périodique
Auteurs :	J. M. CORKERY ; E. DURKIN ; S. ELLIOTT ; F. SCHIFANO ; A. H. GHODSE
Année de publication :	2012
Article en page(s) :	259-262
Langues :	Anglais
Mots-clés :	Thésaurus Géographique ROYAUME-UNI Thésaurus TOXIBASE DROGUES DE SYNTHESE ; ANALYSE CHIMIQUE ; PHARMACOLOGIE ; EFFET SECONDAIRE ; TOXICITE ; MORTALITE ; TOXICOLOGIE
Discipline :	PRO Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods
Domaine :	Drogues illicites / Illicit drugs
Résumé :	5-MeO-DALT (N,N-diallyl-5-methoxytryptamine) is a psychoactive substance, sold primarily over the Internet as a 'research chemical' or 'plant food'. Although details for the synthesis of this tryptamine have been available since 2004, its use as a hallucinogenic drug has been reported only occasionally in on-line user fora. It is controlled in only a few countries world-wide. There is little scientifically-based literature on the pharmacological, physiological, psychopharmacological, toxicological and epidemiological characteristics of 5-MeO-DALT. Here we review what is known about these aspects. We also report what we believe to be the first death involving the use of this substance. The case involved a man in his mid-20s who died in mid-2010. The coroner concluded that the deceased "died from injuries sustained after being hit by a lorry whilst under the influence of 5-MeODALT". It is critical that any other cases, including non-fatal instances, are documented so that a scientific evidence-base can be established for this drug. HIGHLIGHTS: • 5-MeO-DALT is a psychoactive substance sold as a 'research chemical'. • Use as a hallucinogenic is reported by user fora; it can affect risk assessment. • Scant scientific literature on physical effects, psychopharmacology, toxicology. • Victim died from injuries sustained when hit by a vehicle whilst under its influence. • Any (non-) fatal cases need documenting to establish scientific evidence-base.
Sous-type de document :	Revue de la littérature / Literature review
Affiliation :	National Programme for Substance Abuse Deaths (np-SAD), International Centre for Drug Policy, St George's, University of London, London, UK
Permalink :	https://bdoc.ofdt.fr/index.php?lvl=notice_display&id=72176

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Progress in Neuro-Psychopharmacology and Biological Psychiatry . Vol.39, n°2

New drugs of abuse
Mention de date : 3 December 2012
Paru le : 03/12/2012

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Progress in Neuro-Psychopharmacology and Biological Psychiatry . Vol.39, n°2

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