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Auteur P. BRAMLEY
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Modelling the impact of incarceration and prison-based hepatitis C virus (HCV) treatment on HCV transmission among people who inject drugs in Scotland / J. STONE ; N. K. MARTIN ; M. HICKMAN ; S. J. HUTCHINSON ; E. ASPINALL ; A. TAYLOR ; A. MUNRO ; K. DUNLEAVY ; E. PETERS ; P. BRAMLEY ; P. C. HAYES ; D. J. GOLDBERG ; P. VICKERMAN in Addiction, Vol.112, n°7 (July 2017)
Titre : Modelling the impact of incarceration and prison-based hepatitis C virus (HCV) treatment on HCV transmission among people who inject drugs in Scotland Type de document : Périodique Auteurs : J. STONE ; N. K. MARTIN ; M. HICKMAN ; S. J. HUTCHINSON ; E. ASPINALL ; A. TAYLOR ; A. MUNRO ; K. DUNLEAVY ; E. PETERS ; P. BRAMLEY ; P. C. HAYES ; D. J. GOLDBERG ; P. VICKERMAN Année de publication : 2017 Article en page(s) : 1302-1314 Langues : Anglais (eng) Mots-clés : Thésaurus Géographique
ECOSSE ; ROYAUME-UNI
HEPATITE ; PRISON ; INCARCERATION ; TRAITEMENT DE MAINTENANCE ; CONTAMINATION ; USAGER ; INJECTION ; MODELE STATISTIQUE
Discipline : MAL Maladies infectieuses / Infectious diseases Résumé : Background and Aims: People who inject drugs (PWID) experience high incarceration rates, and previous incarceration is associated with elevated hepatitis C virus (HCV) transmission risk. In Scotland, national survey data indicate lower HCV incidence in prison than the community (4.3 versus 7.3 per 100 person-years), but a 2.3-fold elevated transmission risk among recently released ( Design: Dynamic mathematical modelling of incarceration and HCV transmission, using approximate Bayesian computation for model calibration.
Setting: Scotland, UK.
Participants: A simulated population of PWID.
Measurements: Population-attributable fraction (PAF) of incarceration to HCV transmission among PWID. Decrease in HCV incidence and chronic prevalence due to current levels of prison opiate substitution therapy (OST; 57% coverage) and HCV treatment, as well as scaling-up DAAs in prison and/or preventing the elevated risk associated with prison release.
Findings: Incarceration contributes 27.7% [PAF; 95% credible interval (CrI) -3.1 to 51.1%] of HCV transmission among PWID in Scotland. During the next 15 years, current HCV treatment rates (10.4/6.8 per 1000 incarcerated/community PWID annually), with existing prison OST, could reduce incidence and chronic prevalence among all PWID by a relative 10.7% (95% CrI = 8.4-13.3%) and 9.7% (95% CrI = 7.7-12.1%), respectively. Conversely, without prison OST, HCV incidence and chronic prevalence would decrease by 3.1% (95% CrI = -28.5 to 18.0%) and 4.7% (95% CrI = -11.3 to 14.5%). Additionally, preventing the heightened risk among recently released PWID could reduce incidence and chronic prevalence by 45.0% (95% CrI = 19.7-57.5%) and 33.3% (95% CrI = 15.6-43.6%) or scaling-up prison HCV treatments to 80% of chronic PWID prison entrants with sufficient sentences (>16 weeks) could reduce incidence and prevalence by 45.6% (95% CrI = 38.0-51.3%) and 45.5% (95% CrI = 39.3-51.0%), respectively.
Conclusions: Incarceration and the elevated transmission risk following prison release can contribute significantly to hepatitis C virus transmission among people who inject drugs. Scaling-up hepatitis C virus treatment in prison can provide important prevention benefits.
Domaine : Drogues illicites / Illicit drugs Refs biblio. : 47 Affiliation : School of Social and Community Medicine, University of Bristol, Bristol, UK Cote : Abonnement Lien : http://dx.doi.org/10.1111/add.13783 Permalink :
in Addiction > Vol.112, n°7 (July 2017) . - 1302-1314[article]