A 6-year review of new psychoactive substances at the Centre antipoison Grand-Ouest d'Angers: Clinical and biological data / A. TURCANT ; M. DEGUIGNE ; S. FÉREC ; C. BRUNEAU ; I. LEBORGNE ; B. LELIÈVRE ; C. GEGU ; F. JEGOU ; C. ABBARA ; G. LE ROUX ; D. BOELS in Toxicologie Analytique et Clinique, Vol.29, n°1 (Février 2017)    

Donner un avis [article]  inToxicologie Analytique et Clinique > Vol.29, n°1 (Février 2017) . - 18-33 Titre : A 6-year review of new psychoactive substances at the Centre antipoison Grand-Ouest d'Angers: Clinical and biological data Type de document : Périodique Auteurs : A. TURCANT ; M. DEGUIGNE ; S. FÉREC ; C. BRUNEAU ; I. LEBORGNE ; B. LELIÈVRE ; C. GEGU ; F. JEGOU ; C. ABBARA ; G. LE ROUX ; D. BOELS Année de publication : 2017 Article en page(s) : 18-33 Langues : Anglais (eng) Mots-clés : Thésaurus Géographique FRANCE Thésaurus TOXIBASE DROGUES DE SYNTHESE ; PHENOMENE EMERGENT ; DEPISTAGE ; TOXICOLOGIE ; CATHINONE ; EFFET SECONDAIRE ; KETAMINE ; ETUDE DE CAS ; CANNABINOIDES ; ANALYSE CHIMIQUE Discipline : PRO Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods Résumé : For the last 10 years, recreational use of new psychoactive substances (NPS) with hallucinogenic properties was more and more described either in a context of consumption during a rave-party or at home alone or in small group. A review of 62 cases (56 M, 6 F, 16-46 y) registered from 2011 to 2016 at the French Grand Ouest centre antipoison of Angers is presented. Some of them (n = 15) presented a severe clinical state (poison severity score, PSS = 3) and only one was a fatal intoxication (PSS = 4). Treatment of acute intoxication was mainly based on supportive care with a quick recovery in less than 48 h. A high number of these cases were documented by plasma (pl) and/or urine analyses using LC-UV, GC-MS and LC-MS². Several powders or other forms bought on the web market by the patients were also analysed. Six amphetamines derivates were detected such as methiopropamine (pl: 50 - 430 µg/L, n = 6) or 5 others (6-APB, 6-APDB, 5-EAPB, 5-MAPB, 2-FA each once). Four 2,5-dimethoxy-derivates of phenylethylamines (2Cs) or of amphetamines (DOs) were detected as 2C-P (pl: Domaine : Autres substances / Other substances ; Drogues illicites / Illicit drugs Refs biblio. : 48 Affiliation : Laboratoire de pharmacologie-toxicologie, institut de biologie en santé, CHU d’Angers, Angers, France Cote : Abonnement Lien : http://www.sciencedirect.com/science/journal/23520078/29/1 Permalink : https://bdoc.ofdt.fr/index.php?lvl=notice_display&id=78625 [article]