Buprenorphine/naloxone vs methadone for the treatment of opioid use disorder

B. NOSYK ; J. E. MIN ; F. HOMAYRA ; M. KURZ ; B. C. GUERRA-ALEJOS ; R. YAN ; M. PISKE ; S. R. SEAMAN ; P. BACH ; S. GREENLAND ; M. E. KARIM ; U. SIEBERT ; J. BRUNEAU ; P. GUSTAFSON ; K. KAMPMAN ; P. T. KORTHUIS ; T. LOUGHIN ; L. C. MCCANDLESS ; R. W. PLATT ; K. T. SCHNEPEL ; M. E. SOCIAS | 2024
Dans Journal of the American Medical Association (Vol.332, n°21, December 3, 2024) Article : Périodique

Key points: Question: Is buprenorphine/naloxone associated with lower risk of treatment discontinuation and mortality compared with methadone? Findings: In this population-based retrospective cohort study that included 30?891 individuals initi[...]

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Nouveauté

Comparative effectiveness of urine drug testing schedules alongside opioid agonist treatment: Emulation of a population-based target trial in British Columbia, Canada

M. KURZ ; B. C. GUERRA-ALEJOS ; J. E. MIN ; S. R. SEAMAN ; M. PISKE ; P. BACH ; J. BRUNEAU ; S. GREENLAND ; P. GUSTAFSON ; K. KAMPMAN ; M. E. KARIM ; P. T. KORTHUIS ; R. W. PLATT ; U. SIEBERT ; M. E. SOCIAS ; E. WOOD ; B. NOSYK | 2025
Dans Addiction (Vol.120, n°12, December 2025) Article : Périodique

BACKGROUND AND AIM: Urine drug testing is often utilized alongside opioid agonist treatment to assess client progress by validating self-reported substance use, monitoring for diversion and supporting clinical decisions for take-home dosing. How[...]

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Comparative efficacy and safety of pharmacotherapies for alcohol withdrawal: A systematic review and network meta-analysis

A. BAHJI ; P. BACH ; M. DANILEWITZ ; D. CROCKFORD ; N. EL-GUEBALY ; D. J. DEVOE ; R. SAITZ | 2022
Dans Addiction (Vol.117, n°10, October 2022) Article : Périodique

BACKGROUND AND AIMS: There have been few head-to-head clinical trials of pharmacotherapies for alcohol withdrawal (AW). We, therefore, aimed to evaluate the comparative performance of pharmacotherapies for AW. METHODS: Six databases were search[...]

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The impact of benzodiazepine use on mortality among polysubstance users in Vancouver, Canada

G. R. WALTON ; K. HAYASHI ; P. BACH ; H. DONG ; T. KERR ; K. AHAMAD ; M. J. MILLOY ; J. MONTANER ; E. WOOD | 2016
Dans Public Health Reports (Vol.131, n°3, May-June 2016) Article : Périodique

OBJECTIVE: Illicit drug use is a well-established risk factor for increased morbidity and mortality. However, little is known about the impact of benzodiazepine use on mortality among populations of polysubstance users. This study aimed to ident[...]

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