QT interval prolongation: prevalence, risk factors and pharmacovigilance data among methadone-treated patients in France

A. PERRIN-TERRIN ; A. PATHAK ; M. LAPEYRE-MESTRE | 2011
Dans Fundamental and Clinical Pharmacology (Vol.25, n°4, August 2011) Article : Périodique

Several reports have suggested the role of methadone in QT prolongation, Torsades de Pointes (TdP), and ventricular arrhythmia. The aim of this study was to identify the frequency of QT interval prolongation and QT dispersion among a population [...]

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Valvular heart disease in a patient taking 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') [Letter]

F. MONTASTRUC ; G. MONTASTRUC ; P. VIGREUX ; P. BRUNEVAL ; C. GUILBEAU-FRUGIER ; C. CRON ; H. BAGHERI ; B. DELISLE ; M. LAPEYRE-MESTRE ; A. PATHAK ; J. L. MONTASTRUC | 2012
Dans British Journal of Clinical Pharmacology (Vol.74, n°3, September 2012) Article : Périodique

3,4-methylenedioxymethamphetamine, (MDMA, 'Ecstasy'), an amphetamine-derived drug, is a psychoactive stimulant used as a recreational drug. In vitro experiments have suggested that ecstasy can lead to fenfluramine-like proliferation of cardiac v[...]

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