Marijuana-based drugs: innovative therapeutics or designer drugs of abuse?

K. A. SEELY ; P. L. PRATHER ; L. P. JAMES ; J. H. MORAN | 2011
Dans Molecular Interventions (Vol.11, n°1, February 2011) Article : Périodique

The principal psychoactive component of marijuana, Δ9-tetrahydrocannabinol (THC), activates CB1 cannabinoid receptors (CB1Rs). Unfortunately, pharmacological research into the design of effective THC analogs has been hampered by psychiatric side[...]

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Spice drugs are more than harmless herbal blends: a review of the pharmacology and toxicology of synthetic cannabinoids

K. A. SEELY ; J. LAPOINT ; J. H. MORAN ; L. FATTORE | 2012
Dans Progress in Neuro-Psychopharmacology and Biological Psychiatry (Vol.39, n°2, 3 December 2012) Article : Périodique

"K2" and "Spice" drugs (collectively hereafter referred to as Spice) represent a relatively new class of designer drugs that have recently emerged as popular alternatives to marijuana, otherwise characterized as "legal highs". These drugs are re[...]

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