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Auteur D. J. GOLDBERG
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Association between harm reduction intervention uptake and recent hepatitis C infection among people who inject drugs attending sites that provide sterile injecting equipment in Scotland / E. J. ALLEN ; N. E. PALMATEER ; S. J. HUTCHINSON ; S. CAMERON ; D. J. GOLDBERG ; A. TAYLOR in International Journal of Drug Policy, Vol.23, n°5 (September 2012)
Titre : Association between harm reduction intervention uptake and recent hepatitis C infection among people who inject drugs attending sites that provide sterile injecting equipment in Scotland Type de document : Périodique Auteurs : E. J. ALLEN ; N. E. PALMATEER ; S. J. HUTCHINSON ; S. CAMERON ; D. J. GOLDBERG ; A. TAYLOR Année de publication : 2012 Article en page(s) : 346-352 Langues : Anglais (eng) Mots-clés : Thésaurus Géographique
ECOSSE ; ROYAUME-UNI
REDUCTION DES RISQUES ; HEPATITE ; INTERVENTION ; MATERIEL D'INJECTION ; INFECTION ; USAGER ; METHADONE
Discipline : MAL Maladies infectieuses / Infectious diseases Résumé : Background: Prevalence of the hepatitis C virus (HCV) among people who inject drugs (PWID) in Scotland is high. The Scottish Government has invested significantly in harm reduction interventions with the goal of reducing HCV transmission among PWID. In evaluating the effectiveness of interventions, estimates of HCV incidence are essential.
Methods: During 2008-2009, PWID were recruited from services providing sterile injecting equipment across mainland Scotland, completed an interviewer-administered questionnaire and provided a dried blood spot for anonymous anti-HCV and HCV-RNA testing. Recent infections were defined as anti-HCV negative and HCV-RNA positive. Logistic regression was undertaken to examine associations between recent HCV infection and self-reported uptake of methadone maintenance therapy (MMT) and injection equipment.
Results: Fifty-four percent (1367/2555) of participants were anti-HCV positive. We detected 24 recent HCV infections, yielding incidence rate estimates ranging from 10.8 to 21.9 per 100 person-years. After adjustment for confounders, those with high needle/syringe coverage had reduced odds of recent infection (adjusted odds ratio [AOR] 0.32, 95% CI 0.10-1.00, p = 0.050). In the Greater Glasgow & Clyde region only, we observed a reduced odds of recent infection among those currently receiving MMT, relative to those on MMT in the last six months but not currently (AOR 0.04, 95% CI 0.001-1.07, p = 0.055). The effect of combined uptake of MMT and high needle/syringe coverage was only significant in unadjusted analyses (OR 0.34, 95% CI 0.12-0.97, p = 0.043; AOR 0.48, 95% CI 0.16-1.48, p = 0.203).
Conclusion: We report the first large-scale, national application of a novel method designed to determine incidence of HCV among PWID using a cross-sectional design. Subsequent sweeps of this survey will increase statistical power and allow us to gauge the impact of preventive interventions.
Domaine : Drogues illicites / Illicit drugs Affiliation : Health Protection Scotland, Glasgow, UK Cote : Abonnement Permalink :
in International Journal of Drug Policy > Vol.23, n°5 (September 2012) . - 346-352[article]Combination interventions to prevent HCV transmission among people who inject drugs: modeling the impact of antiviral treatment, needle and syringe programs, and opiate substitution therapy / N. K. MARTIN ; M. HICKMAN ; S. J. HUTCHINSON ; D. J. GOLDBERG ; P. VICKERMAN in Clinical Infectious Diseases, Vol.57, Suppl.2 (August 2013)
Titre : Combination interventions to prevent HCV transmission among people who inject drugs: modeling the impact of antiviral treatment, needle and syringe programs, and opiate substitution therapy Type de document : Périodique Auteurs : N. K. MARTIN ; M. HICKMAN ; S. J. HUTCHINSON ; D. J. GOLDBERG ; P. VICKERMAN Année de publication : 2013 Article en page(s) : S39-S45 Langues : Anglais (eng) Mots-clés : Thésaurus Géographique
HEPATITE ; INTERVENTION ; USAGER ; REDUCTION DES RISQUES ; MODELE ; TRAITEMENT DE MAINTENANCE ; ECHANGE DE SERINGUES ; ANTIVIRAUX ; PREVALENCE
Discipline : MAL Maladies infectieuses / Infectious diseases Résumé : BACKGROUND: Interventions such as opiate substitution therapy (OST) and high-coverage needle and syringe programs (HCNSP) cannot substantially reduce hepatitis C virus (HCV) prevalence among people who inject drugs (PWID). HCV antiviral treatment may prevent onward transmission. We project the impact of combining OST, HCNSP, and antiviral treatment on HCV prevalence/incidence among PWID.
METHODS: An HCV transmission model among PWID was used to project the combinations of OST, HCNSP, and antiviral treatment required to achieve different prevalence and incidence reductions within 10 years for 3 chronic prevalence scenarios and the impact of HCV treatment if only delivered through OST programs. Multivariate and univariate sensitivity analyses were performed.
RESULTS: Large reductions (>45%) in HCV chronic prevalence over 10 years require HCV antiviral treatment. Scaling up OST and HCNSP substantially reduces the treatment rate required to achieve specific HCV prevalence reductions. If OST and HCNSP coverage were increased to 40% each (no coverage at baseline), then annually treating 10, 23, or 42 per 1000 PWID over 10 years would halve prevalence for 20%, 40%, or 60% baseline chronic HCV prevalences, respectively. Approximately 30% fewer treatments are necessary with new direct-acting antivirals. If coverage of OST and HCNSP is 50% at baseline, similar prevalence reductions require higher treatment rates for the same OST and HCNSP coverage.
CONCLUSIONS: Combining antiviral treatment with OST with HCNSP is critical for achieving substantial reductions (>50%) in HCV chronic prevalence over 10 years. Empirical studies are required on how best to scale up antiviral treatment and combine treatment with other interventions.
Domaine : Drogues illicites / Illicit drugs Refs biblio. : 30 Affiliation : School of Social and Community Medicine, University of Bristol, UK Lien : http://dx.doi.org/10.1093/cid/cit296 Permalink :
in Clinical Infectious Diseases > Vol.57, Suppl.2 (August 2013) . - S39-S45[article]Drug-related deaths by region, sex, and age group per 100 injecting drug users in Scotland, 2000-01 / S. M. BIRD
Titre : Drug-related deaths by region, sex, and age group per 100 injecting drug users in Scotland, 2000-01 Titre traduit : (Mortalité liée à l'usage de drogue par région, sexe et groupe d'âge chez 100 usagers de drogue par injection en Ecosse, 2000-01) Type de document : Périodique Auteurs : S. M. BIRD ; S. J. HUTCHINSON ; D. J. GOLDBERG Année de publication : 2003 Importance : 941-944 Présentation : tabl. Note générale : The Lancet, 2003, 362, 941-944 Langues : Français (fre) Mots-clés : Thésaurus TOXIBASE
MORTALITE ; EPIDEMIOLOGIE DESCRIPTIVE ; SEXE ; REGION ; AGE ; USAGER ; INJECTION
Discipline : EPI Epidémiologie / Epidemiology Résumé :
Background. In 2000 and 2001, there were 292 and 332 drug-related deaths in Scotland, respectively. Of the 332 people who died in 2001, 65 were of female sex, 80 were younger than 25 years, and 112 were older than 34 yaers. We assessed the effect of region, sex, and age group on drug-related deaths in Scotland per 100 injecting drug users. Methods. We used published regional estimates of current injecting drug users (n=22 805), their sex (30% female) and age distribution (8% older than 34 years in mid-1990s), or corresponding data for problem drug users (21% older than 34 years in 2000) to compare observed with expected drug-related deaths by region, sex, and age group pe 1000 population or per 100 injecting drug users. Findings. Regional population-based expectations fitted poorly to observed drug-related deaths in 2001 per 100 injecting drug users were significantly lower in female (0.9 [95% CI0.6-1.1]) than in male drug users (1.5;1.3-1.7). They were between two and six times more frequent per 100 injecting drug users older than 34 years than younger than 25 years, depending on wether curren injecting drug users' age distribution was assumed to be the same as problem drug users' or as injecting drug users' in the mid-1990s (2.1[1.7-2.5] or 5.3[4.3-6.3], respectively). Interpretation. Older and male injecting drug userswere at highest risk of drug-related death. Injecting drug users' age distribution should be assessed and compared across countries. (Review' s abstract)
Note de contenu : tabl. Domaine : Drogues illicites / Illicit drugs Refs biblio. : 18 Affiliation : Royaume-Uni. United Kingdom. Numéro Toxibase : 207348 Centre Emetteur : 02 Coordonnateur Permalink : Estimating the number of people with hepatitis C virus who have ever injected drugs and have yet to be diagnosed: an evidence synthesis approach for Scotland / T. C. PREVOST ; A. M. PRESANIS ; A. TAYLOR ; D. J. GOLDBERG ; S. J. HUTCHINSON ; D. DE ANGELIS in Addiction, Vol.110, n°8 (August 2015)
Titre : Estimating the number of people with hepatitis C virus who have ever injected drugs and have yet to be diagnosed: an evidence synthesis approach for Scotland Type de document : Périodique Auteurs : T. C. PREVOST ; A. M. PRESANIS ; A. TAYLOR ; D. J. GOLDBERG ; S. J. HUTCHINSON ; D. DE ANGELIS Année de publication : 2015 Article en page(s) : 1287-1300 Langues : Anglais (eng) Mots-clés : Thésaurus Géographique
ECOSSE ; ROYAUME-UNI
HEPATITE ; USAGER ; INJECTION ; PREVALENCE ; DIAGNOSTIC
Discipline : MAL Maladies infectieuses / Infectious diseases Résumé : Aims: To estimate the number of people who have ever injected drugs (defined here as PWID) living in Scotland in 2009 who have been infected with the hepatitis C virus (HCV) and to quantify and characterize the population remaining undiagnosed.
Methods: Information from routine surveillance (n = 22 616) and survey data (n = 2511) was combined using a multiparameter evidence synthesis approach to estimate the size of the PWID population, HCV antibody prevalence and the proportion of HCV antibody prevalent cases who have been diagnosed, in subgroups defined by recency of injecting (in the last year or not), age (15-34 and 35-64 years), gender and region of residence (Greater Glasgow and Clyde and the rest of Scotland).
Results: HCV antibody-prevalence among PWID in Scotland during 2009 was estimated to be 57% [95% CI = 52-61%], corresponding to 46?657 [95% credible interval (CI) = 33 812-66 803] prevalent cases. Of these, 27 434 (95% CI = 14 636-47 564) were undiagnosed, representing 59% [95% CI=43-71%] of prevalent cases. Among the undiagnosed, 83% (95% CI = 75-89%) were PWID who had not injected in the last year and 71% (95% CI = 58-85%) were aged 35-64 years.
Conclusions: The number of undiagnosed hepatitis C virus-infected cases in Scotland appears to be particularly high among those who have injected drugs more than 1 year ago and are more than 35 years old.
Domaine : Drogues illicites / Illicit drugs Refs biblio. : 34 Affiliation : MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, UK Cote : Abonnement Lien : http://dx.doi.org/10.1111/add.12948 Permalink :
in Addiction > Vol.110, n°8 (August 2015) . - 1287-1300[article]Estimating the population prevalence of injection drug use and infection with human immunodeficiency virus among injection drug users in Glasgow, Scotland / M. FRISCHER
Titre : Estimating the population prevalence of injection drug use and infection with human immunodeficiency virus among injection drug users in Glasgow, Scotland Type de document : Périodique Auteurs : M. FRISCHER ; LEYLAND A ; CORMACK R ; D. J. GOLDBERG ; M. BLOOR ; S. T. GREEN ; A. TAYLOR ; R. COVELL ; N. McKEGANEY ; S. PLATT Année de publication : 1993 Importance : 170-181 Présentation : tabl. Note générale : American Journal of Epidemiology, 1993, 138, (3), 170-181 Langues : Anglais (eng) Mots-clés : Thésaurus TOXIBASE
PREVALENCE ; INJECTION ; VIH ; MODELE STATISTIQUE
Discipline : MAL Maladies infectieuses / Infectious diseases Résumé :
Although data on the prevalence of injection drug use are an essential prerequisite for estimating the number of individuals infected with the human immunodeficiency virus (HIV), there have been few attempts to utilize statistical methods of population estimation based on multiple data sources. Data on 3,670 cases (2,866 individuals) were obtained from the HIV test register, drug treatment agencies, police records, and needle and syringe exchanges in Glasgow, Scotland, in 1990. Log-linear analysis was used to model the number of individuals in each of the sources. The model incorporating dependency among the three health care agencies (HIV test, drug treatment, and needle exchange) and independence of the police sample fitted the data well, with a residual chi 2 value of 2.9 (6 df). The expected value of the missing cell corresponding to absence from all four samples was 5,628, yielding an overall estimate of 8,494 injectors (95% confidence interval (CI) 7,491-9,721), for a prevalence rate of 1.35% for people aged 15-55 years in Glasgow during 1990. The high ratio of known to unknown injectors (1:2) resulted from the extensive coverage of known injectors and the relatively high level of overlap between the combined health care agency sample and the police sample. While further analysis demonstrated that the probability of appearing in the four samples varied by age and sex, heterogeneity in the population did not affect the choice of model or substantially alter the estimates for the total number of unknown injectors. A concurrent study of a community-wide sample of 503 injectors resulted in an HIV prevalence rate of 1.1% (95% CI 0.4-2.5%). The results of these studies were combined to produce a further estimate of 93 HIV-infected current injectors in Glasgow (95% CI 33-214).
Note de contenu : tabl. Domaine : Drogues illicites / Illicit drugs Refs biblio. : 33 Affiliation : Royaume-Uni. United Kingdom. Numéro Toxibase : 101124 Centre Emetteur : 13 OFDT Cote : A02073 Permalink : Examination of the risk of reinfection with hepatitis C among injecting drug users who have been tested in Glasgow / S. A. McDONALD ; S. J. HUTCHINSON ; S. O. CAMERON ; H. A. INNES ; A. McLEOD ; D. J. GOLDBERG in International Journal of Drug Policy, Vol.23, n°5 (September 2012)PermalinkExpansion of HCV treatment access to people who have injected drugs through effective translation of research into public health policy: Scotland's experience / S. J. HUTCHINSON ; J. F. DILLON ; R. FOX ; S. A. McDONALD ; H. A. INNES ; A. WEIR ; A. McLEOD ; E. J. ASPINALL ; N. E. PALMATEER ; A. TAYLOR ; A. MUNRO ; H. VALERIO ; G. BROWN ; D. J. GOLDBERG in International Journal of Drug Policy, Vol.26, n°11 (November 2015)PermalinkFactors associated with injecting risk behaviour among serial community-wide samples of injecting drug users in Glasgow 1990-94: implications for control and prevention of blood-borne viruses / S. J. HUTCHINSON in Addiction, Vol.95, n°6 (June 2000)PermalinkHas the rate of progression to AIDS changed in recent years ? / N. CARREPermalinkHigh-risk injecting behaviour in hostel accommodation for the homeless in Glasgow 200102: a study combining quantitative and qualitative methodology / S. L. WADD in Journal of Substance Use, Vol.11 n°5 (2006)PermalinkModelling the impact of incarceration and prison-based hepatitis C virus (HCV) treatment on HCV transmission among people who inject drugs in Scotland / J. STONE ; N. K. MARTIN ; M. HICKMAN ; S. J. HUTCHINSON ; E. ASPINALL ; A. TAYLOR ; A. MUNRO ; K. DUNLEAVY ; E. PETERS ; P. BRAMLEY ; P. C. HAYES ; D. J. GOLDBERG ; P. VICKERMAN in Addiction, Vol.112, n°7 (July 2017)PermalinkMortality and cause of death in a cohort of people who had ever injected drugs in Glasgow: 1982-2012 / D. NAMBIAR ; A. WEIR ; E. J. ASPINALL ; M. STOOVE ; S. HUTCHINSON ; P. DIETZE ; L. WAUGH ; D. J. GOLDBERG in Drug and Alcohol Dependence, Vol.147 (February 2015)PermalinkOne-year follow-up of opiate injectors treated with oral methadone in a GP-centred programme / S. J. HUTCHINSONPermalinkPre-AIDS mortality from natural causes associated with HIV disease progression : evidence from the European seroconverter study among injecting drug users / M. PRINSPermalinkPrevalence and determinants of hepatitis C virus infection among female drug injecting sex workers in Glasgow / A. TAYLOR in Harm Reduction Journal, Vol.5 n°11 (2008)Permalink