Association between harm reduction intervention uptake and recent hepatitis C infection among people who inject drugs attending sites that provide sterile injecting equipment in Scotland / E. J. ALLEN ; N. E. PALMATEER ; S. J. HUTCHINSON ; S. CAMERON ; D. J. GOLDBERG ; A. TAYLOR in International Journal of Drug Policy, Vol.23, n°5 (September 2012)

Donner un avis [article]  inInternational Journal of Drug Policy > Vol.23, n°5 (September 2012) . - 346-352 Titre : Association between harm reduction intervention uptake and recent hepatitis C infection among people who inject drugs attending sites that provide sterile injecting equipment in Scotland Type de document : Périodique Auteurs : E. J. ALLEN ; N. E. PALMATEER ; S. J. HUTCHINSON ; S. CAMERON ; D. J. GOLDBERG ; A. TAYLOR Année de publication : 2012 Article en page(s) : 346-352 Langues : Anglais (eng) Mots-clés : Thésaurus Géographique ECOSSE ; ROYAUME-UNI Thésaurus TOXIBASE REDUCTION DES RISQUES ; HEPATITE ; INTERVENTION ; MATERIEL D'INJECTION ; INFECTION ; USAGER ; METHADONE Discipline : MAL Maladies infectieuses / Infectious diseases Résumé : Background: Prevalence of the hepatitis C virus (HCV) among people who inject drugs (PWID) in Scotland is high. The Scottish Government has invested significantly in harm reduction interventions with the goal of reducing HCV transmission among PWID. In evaluating the effectiveness of interventions, estimates of HCV incidence are essential. Methods: During 2008-2009, PWID were recruited from services providing sterile injecting equipment across mainland Scotland, completed an interviewer-administered questionnaire and provided a dried blood spot for anonymous anti-HCV and HCV-RNA testing. Recent infections were defined as anti-HCV negative and HCV-RNA positive. Logistic regression was undertaken to examine associations between recent HCV infection and self-reported uptake of methadone maintenance therapy (MMT) and injection equipment. Results: Fifty-four percent (1367/2555) of participants were anti-HCV positive. We detected 24 recent HCV infections, yielding incidence rate estimates ranging from 10.8 to 21.9 per 100 person-years. After adjustment for confounders, those with high needle/syringe coverage had reduced odds of recent infection (adjusted odds ratio [AOR] 0.32, 95% CI 0.10-1.00, p = 0.050). In the Greater Glasgow & Clyde region only, we observed a reduced odds of recent infection among those currently receiving MMT, relative to those on MMT in the last six months but not currently (AOR 0.04, 95% CI 0.001-1.07, p = 0.055). The effect of combined uptake of MMT and high needle/syringe coverage was only significant in unadjusted analyses (OR 0.34, 95% CI 0.12-0.97, p = 0.043; AOR 0.48, 95% CI 0.16-1.48, p = 0.203). Conclusion: We report the first large-scale, national application of a novel method designed to determine incidence of HCV among PWID using a cross-sectional design. Subsequent sweeps of this survey will increase statistical power and allow us to gauge the impact of preventive interventions. Domaine : Drogues illicites / Illicit drugs Affiliation : Health Protection Scotland, Glasgow, UK Cote : Abonnement Permalink : https://bdoc.ofdt.fr/index.php?lvl=notice_display&id=70570 [article]

Combination interventions to prevent HCV transmission among people who inject drugs: modeling the impact of antiviral treatment, needle and syringe programs, and opiate substitution therapy / N. K. MARTIN ; M. HICKMAN ; S. J. HUTCHINSON ; D. J. GOLDBERG ; P. VICKERMAN in Clinical Infectious Diseases, Vol.57, Suppl.2 (August 2013)  

Donner un avis [article]  inClinical Infectious Diseases > Vol.57, Suppl.2 (August 2013) . - S39-S45 Titre : Combination interventions to prevent HCV transmission among people who inject drugs: modeling the impact of antiviral treatment, needle and syringe programs, and opiate substitution therapy Type de document : Périodique Auteurs : N. K. MARTIN ; M. HICKMAN ; S. J. HUTCHINSON ; D. J. GOLDBERG ; P. VICKERMAN Année de publication : 2013 Article en page(s) : S39-S45 Langues : Anglais (eng) Mots-clés : Thésaurus Géographique ROYAUME-UNI Thésaurus TOXIBASE HEPATITE ; INTERVENTION ; USAGER ; REDUCTION DES RISQUES ; MODELE ; TRAITEMENT DE MAINTENANCE ; ECHANGE DE SERINGUES ; ANTIVIRAUX ; PREVALENCE Discipline : MAL Maladies infectieuses / Infectious diseases Résumé : BACKGROUND: Interventions such as opiate substitution therapy (OST) and high-coverage needle and syringe programs (HCNSP) cannot substantially reduce hepatitis C virus (HCV) prevalence among people who inject drugs (PWID). HCV antiviral treatment may prevent onward transmission. We project the impact of combining OST, HCNSP, and antiviral treatment on HCV prevalence/incidence among PWID. METHODS: An HCV transmission model among PWID was used to project the combinations of OST, HCNSP, and antiviral treatment required to achieve different prevalence and incidence reductions within 10 years for 3 chronic prevalence scenarios and the impact of HCV treatment if only delivered through OST programs. Multivariate and univariate sensitivity analyses were performed. RESULTS: Large reductions (>45%) in HCV chronic prevalence over 10 years require HCV antiviral treatment. Scaling up OST and HCNSP substantially reduces the treatment rate required to achieve specific HCV prevalence reductions. If OST and HCNSP coverage were increased to 40% each (no coverage at baseline), then annually treating 10, 23, or 42 per 1000 PWID over 10 years would halve prevalence for 20%, 40%, or 60% baseline chronic HCV prevalences, respectively. Approximately 30% fewer treatments are necessary with new direct-acting antivirals. If coverage of OST and HCNSP is 50% at baseline, similar prevalence reductions require higher treatment rates for the same OST and HCNSP coverage. CONCLUSIONS: Combining antiviral treatment with OST with HCNSP is critical for achieving substantial reductions (>50%) in HCV chronic prevalence over 10 years. Empirical studies are required on how best to scale up antiviral treatment and combine treatment with other interventions. Domaine : Drogues illicites / Illicit drugs Refs biblio. : 30 Affiliation : School of Social and Community Medicine, University of Bristol, UK Lien : http://dx.doi.org/10.1093/cid/cit296 Permalink : https://bdoc.ofdt.fr/index.php?lvl=notice_display&id=74550 [article]

Does informing people who inject drugs of their hepatitis C status influence their injecting behaviour? Analysis of the Networks II study / E. ASPINALL ; A. WEIR ; R. SACKS-DAVIS ; T. SPELMAN ; J. GREBELY ; P. HIGGS ; S. J. HUTCHINSON ; M. E. HELLARD in International Journal of Drug Policy, Vol.25, n°1 (January 2014)

Donner un avis [article]  inInternational Journal of Drug Policy > Vol.25, n°1 (January 2014) . - 179-182 Titre : Does informing people who inject drugs of their hepatitis C status influence their injecting behaviour? Analysis of the Networks II study Type de document : Périodique Auteurs : E. ASPINALL ; A. WEIR ; R. SACKS-DAVIS ; T. SPELMAN ; J. GREBELY ; P. HIGGS ; S. J. HUTCHINSON ; M. E. HELLARD Année de publication : 2014 Article en page(s) : 179-182 Langues : Anglais (eng) Mots-clés : Thésaurus Géographique AUSTRALIE Thésaurus TOXIBASE HEPATITE ; USAGER ; SEROPOSITIVITE ; INJECTION ; CONDUITE A RISQUE ; DIAGNOSTIC Discipline : MAL Maladies infectieuses / Infectious diseases Résumé : BACKGROUND: People who inject drugs (PWID) are at risk of hepatitis C virus (HCV). It is plausible that PWID who receive a diagnosis of HCV will reduce their injecting risk out of concern for their injecting partners, although evidence for this is currently limited. The aim of this study was to investigate whether informing PWID of their HCV diagnosis was associated with a change in injecting behaviour. METHODS: Prospective, longitudinal study of PWID recruited from street drug markets across Melbourne, Australia. Interviews and HCV testing were conducted at 3-monthly intervals. The association between receiving a diagnosis of HCV and (i) injecting frequency and (ii) injecting equipment borrowing, was examined using generalized estimating equations (GEE) analysis. RESULTS: Thirty-five individuals received a diagnosis of HCV during the study period. Receiving a diagnosis of HCV was associated with a decrease of 0.35 injections per month (p=0.046) but there was no change in injecting equipment borrowing (p=0.750). CONCLUSIONS: A small reduction in injecting frequency was observed in PWID who received a diagnosis of HCV. This finding should be investigated further in larger studies examining a wider range of injecting risk behaviours. Domaine : Drogues illicites / Illicit drugs Affiliation : Glasgow Caledonian University, Glasgow, UK Cote : Abonnement Permalink : https://bdoc.ofdt.fr/index.php?lvl=notice_display&id=73942 [article]

Drug-related deaths by region, sex, and age group per 100 injecting drug users in Scotland, 2000-01 / S. M. BIRD

Donner un avis Titre : Drug-related deaths by region, sex, and age group per 100 injecting drug users in Scotland, 2000-01 Titre traduit : (Mortalité liée à l'usage de drogue par région, sexe et groupe d'âge chez 100 usagers de drogue par injection en Ecosse, 2000-01) Type de document : Périodique Auteurs : S. M. BIRD ; S. J. HUTCHINSON ; D. J. GOLDBERG Année de publication : 2003 Importance : 941-944 Présentation : tabl. Note générale : The Lancet, 2003, 362, 941-944 Langues : Français (fre) Mots-clés : Thésaurus TOXIBASE MORTALITE ; EPIDEMIOLOGIE DESCRIPTIVE ; SEXE ; REGION ; AGE ; USAGER ; INJECTION Thésaurus Géographique ECOSSE Discipline : EPI Epidémiologie / Epidemiology Résumé : ENGLISH : Background. In 2000 and 2001, there were 292 and 332 drug-related deaths in Scotland, respectively. Of the 332 people who died in 2001, 65 were of female sex, 80 were younger than 25 years, and 112 were older than 34 yaers. We assessed the effect of region, sex, and age group on drug-related deaths in Scotland per 100 injecting drug users. Methods. We used published regional estimates of current injecting drug users (n=22 805), their sex (30% female) and age distribution (8% older than 34 years in mid-1990s), or corresponding data for problem drug users (21% older than 34 years in 2000) to compare observed with expected drug-related deaths by region, sex, and age group pe 1000 population or per 100 injecting drug users. Findings. Regional population-based expectations fitted poorly to observed drug-related deaths in 2001 per 100 injecting drug users were significantly lower in female (0.9 [95% CI0.6-1.1]) than in male drug users (1.5;1.3-1.7). They were between two and six times more frequent per 100 injecting drug users older than 34 years than younger than 25 years, depending on wether curren injecting drug users' age distribution was assumed to be the same as problem drug users' or as injecting drug users' in the mid-1990s (2.1[1.7-2.5] or 5.3[4.3-6.3], respectively). Interpretation. Older and male injecting drug userswere at highest risk of drug-related death. Injecting drug users' age distribution should be assessed and compared across countries. (Review' s abstract) Note de contenu : tabl. Domaine : Drogues illicites / Illicit drugs Refs biblio. : 18 Affiliation : Royaume-Uni. United Kingdom. Numéro Toxibase : 207348 Centre Emetteur : 02 Coordonnateur Permalink : https://bdoc.ofdt.fr/index.php?lvl=notice_display&id=19672

Estimating prevalence of injecting drug users and associated heroin-related death rates in England by using regional data and incorporating prior information / R. KING ; S. M. BIRD ; A. OVERSTALL ; G. HAY ; S. J. HUTCHINSON in Journal of the Royal Statistical Society: Series A-Statistics in Society, Vol.177, n°1 (January 2014)  

Donner un avis [article]  inJournal of the Royal Statistical Society: Series A-Statistics in Society > Vol.177, n°1 (January 2014) . - 209-236 Titre : Estimating prevalence of injecting drug users and associated heroin-related death rates in England by using regional data and incorporating prior information Type de document : Périodique Auteurs : R. KING ; S. M. BIRD ; A. OVERSTALL ; G. HAY ; S. J. HUTCHINSON Année de publication : 2014 Article en page(s) : 209-236 Langues : Anglais (eng) Mots-clés : Thésaurus Géographique ANGLETERRE ; ROYAUME-UNI Thésaurus TOXIBASE PREVALENCE ; EVALUATION ; USAGER ; INJECTION ; HEROINE ; MORTALITE ; MODELE STATISTIQUE ; POPULATION CACHEE ; REGION Discipline : EPI Epidémiologie / Epidemiology Résumé : Injecting drug users (IDUs) have a direct social and economic effect yet can typically be regarded as a hidden population within a community. We estimate the size of the IDU population across the nine different Government Office regions of England in 2005-2006 by using capture-recapture methods with age (ranging from 15 to 64 years) and gender as covariate information. We consider a Bayesian model averaging approach using log-linear models, where we can include explicit prior information within the analysis in relation to the total IDU population (elicited from the number of drug-related deaths and injectors' drug-related death rates). Estimation at the regional level allows for regional heterogeneity with these regional estimates aggregated to obtain a posterior mean estimate for the number of England's IDUs of 195840 with 95% credible interval (181700, 210480). There is significant variation in the estimated regional prevalence of current IDUs per million of population aged 15-64 years, and in injecting drug-related death rates across the gender x age cross-classifications. The propensity of an IDU to be seen by at least one source also exhibits strong regional variability with London having the lowest propensity of being observed (posterior mean probability 0.21) and the South West the highest propensity (posterior mean 0.46). Domaine : Drogues illicites / Illicit drugs Affiliation : University of St Andrews, UK Lien : http://dx.doi.org/10.1111/rssa.12011 Permalink : https://bdoc.ofdt.fr/index.php?lvl=notice_display&id=73868 [article]

Estimating the number of people with hepatitis C virus who have ever injected drugs and have yet to be diagnosed: an evidence synthesis approach for Scotland / T. C. PREVOST ; A. M. PRESANIS ; A. TAYLOR ; D. J. GOLDBERG ; S. J. HUTCHINSON ; D. DE ANGELIS in Addiction, Vol.110, n°8 (August 2015)  

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Examination of the risk of reinfection with hepatitis C among injecting drug users who have been tested in Glasgow / S. A. McDONALD ; S. J. HUTCHINSON ; S. O. CAMERON ; H. A. INNES ; A. McLEOD ; D. J. GOLDBERG in International Journal of Drug Policy, Vol.23, n°5 (September 2012)

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Expansion of HCV treatment access to people who have injected drugs through effective translation of research into public health policy: Scotland's experience / S. J. HUTCHINSON ; J. F. DILLON ; R. FOX ; S. A. McDONALD ; H. A. INNES ; A. WEIR ; A. McLEOD ; E. J. ASPINALL ; N. E. PALMATEER ; A. TAYLOR ; A. MUNRO ; H. VALERIO ; G. BROWN ; D. J. GOLDBERG in International Journal of Drug Policy, Vol.26, n°11 (November 2015)

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Factors associated with injecting risk behaviour among serial community-wide samples of injecting drug users in Glasgow 1990-94: implications for control and prevention of blood-borne viruses / S. J. HUTCHINSON in Addiction, Vol.95, n°6 (June 2000)

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Global policy and access to new hepatitis C therapies for people who inject drugs / J. S. DOYLE ; E. J. ASPINALL ; S. J. HUTCHINSON ; B. QUINN ; C. GORE ; S. Z. WIKTOR ; M. E. HELLARD in International Journal of Drug Policy, Vol.26, n°11 (November 2015)

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High-risk injecting behaviour in hostel accommodation for the homeless in Glasgow 200102: a study combining quantitative and qualitative methodology / S. L. WADD in Journal of Substance Use, Vol.11 n°5 (2006)

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Injecting drug users in Scotland, 2006: Listing, number, demography, and opiate-related death-rates / R. KING ; S. M. BIRD ; A. OVERSTALL ; G. HAY ; S. J. HUTCHINSON in Addiction Research and Theory, Vol.21, n°3 (June 2013)  

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Interventions to prevent HIV and Hepatitis C in people who inject drugs: A review of reviews to assess evidence of effectiveness / G. J. MACARTHUR ; E. VAN VELZEN ; N. E. PALMATEER ; J. KIMBER ; A. PHARRIS ; V. HOPE ; A. TAYLOR ; K. ROY ; E. ASPINALL ; D. GOLDBERG ; T. RHODES ; D. HEDRICH ; M. SALMINEN ; M. HICKMAN ; S. J. HUTCHINSON in International Journal of Drug Policy, Vol.25, n°1 (January 2014)

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Male drugs-related deaths in the fortnight after release from prison: Scotland, 1996-99 / S. M. BIRD

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Modelling the impact of incarceration and prison-based hepatitis C virus (HCV) treatment on HCV transmission among people who inject drugs in Scotland / J. STONE ; N. K. MARTIN ; M. HICKMAN ; S. J. HUTCHINSON ; E. ASPINALL ; A. TAYLOR ; A. MUNRO ; K. DUNLEAVY ; E. PETERS ; P. BRAMLEY ; P. C. HAYES ; D. J. GOLDBERG ; P. VICKERMAN in Addiction, Vol.112, n°7 (July 2017)    

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