A clinical pharmacological study of subcutaneous nicotine

J. LE HOUEZEC ; P. JACOB III ; N. L. BENOWITZ | 1993
Dans European Journal of Clinical Pharmacology (Vol.44, n°3, March 1993) Article : Périodique

The stable isotope-labeled compound 3',-3'-dideuteronicotine (nicotine-d2) was used to investigate the disposition kinetics and effects of nicotine administered subcutaneously to 6 smokers. Plasma nicotine-d2 concentrations were measured for 8 h[...]

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Urine toxicology samples in cocaine treatment trials: how many need to be tested?

K. L. DELUCCHI ; S. L. BATKI ; J. MOON ; P. JACOB III ; R. T. JONES | 2002
Périodique

ENGLISH : How frequently should urine samples be collected and analyzed to accurately measure drug use in clinical trials of cocaine abuse treatments? Previous research suggests that analyzing one of three weekly urine toxicology samples in an[...]

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