Association of a CB1 Cannabinoid Receptor Gene (CNR1) polymorphism with severe alcohol dependence

L. G. SCHMIDT ; SAMOCHOWIEC J. ; U. FINCKH ; FISZER-PIOSIK E. ; HORODNICKI J. ; B. WENDEL ; H. ROMMELSPACHER ; HOEHE M. R. | 2002
Périodique

ENGLISH : Due to the involvement of the endogenous cannabinoid system in brain reward mechanisms a silent polymorphism (1359G/A; Thr453Thr) in the single coding exon of the CB1 human cannabinoid receptor gene (CNRI) was analysed in 121 severel[...]

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Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependence

P. FRANKE ; B. WENDEL ; M. KNAPP ; SCHWAB S. G. ; NEEF D. ; W. MAIER ; WILDENAUER D. B. ; HOEHE M. R. | 2003
Dans European Psychiatry (Vol.18, n°1, February 2003) Article : Périodique

Objective. - In a modified case-control association study we tested the assumption that two polymorphisms (A118 in exon 1 and IVS2+31 in intron 2) of the human µ-opioid receptor gene (OPRM1) confer susceptibility to opioid dependence. Methods. -[...]

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