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Auteur L. LI
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Abstinence trajectories among treated crack cocaine users / H. A. SIEGAL
Titre : Abstinence trajectories among treated crack cocaine users Titre traduit : (Trajectoires d'abstinence parmi des patients traités pour usage de crack et de cocaïne) Type de document : Périodique Auteurs : H. A. SIEGAL ; L. LI ; R. C. RAPP Année de publication : 2002 Importance : 437-449 Présentation : graph. ; tabl. Note générale : Addictive Behaviors, 2002, 27, (3), 437-449 Langues : Anglais (eng) Mots-clés : Thésaurus TOXIBASE
TRAITEMENT ; ABSTINENCE ; CRACK ; COCAINE ; TRAJECTOIRE ; COMPARAISON
Discipline : TRA Traitement et prise en charge / Treatment and care Résumé : This article reports findings from a study that investigated treatment outcomes among crack/cocaine users over a 18-month period. From a cohort of 229 subjects, three groups emerged: (1) those who had reported ongoing, stable abstinence from crack/cocaine; (2) those who had consistently used during the period; and (3) those who reported cycling between abstinence and use during the follow-up period. Analyses of variance (ANOVA) were conducted to compare the three groups in terms of intake characteristics, including demographic profile, previous treatment, motivational factors, and functioning in seven Addiction Severity Index (ASI) domains. Length of time involved in aftercare and Twelve Step participation after treatment were also contrasted among the three groups. Results showed that subjects who achieved sustained abstinence from crack/cocaine also did better in other domains such as employment, family, legal, and psychiatric than others. Stable abstinence was also significantly associated with a longer period of aftercare and frequent attendance at Twelve Step programs. Logistic regression analyses further estimated the significant impact of the posttreatment factors on the achievement of sustained abstinence. The implications of these findings for treatment services research are discussed. (Editor's abstract.) Domaine : Drogues illicites / Illicit drugs Refs biblio. : 34 Affiliation : Ctr. Interventions, Treatment, Addictions Res., Wright State Univ. Sch. Med, 216 Med. Sciences Building, Dayton, OH 45435.
Etats-Unis. United States.
Numéro Toxibase : 403841 Centre Emetteur : 04 CIRDD-51 Permalink : Les antagonistes du récepteur CB1 des cannabinoïdes : une nouvelle approche pour le traitement de la fibrose hépatique / F. TEIXEIRA-CLERC in Médecine/Sciences, Vol.22, n°8-9 (Août-Septembre 2006)
Titre : Les antagonistes du récepteur CB1 des cannabinoïdes : une nouvelle approche pour le traitement de la fibrose hépatique Titre traduit : (CB1 cannabinoid receptor antagonists: a novel approach for the treatment of liver fibrosis) Type de document : Périodique Auteurs : F. TEIXEIRA-CLERC ; B. JULIEN ; P. GRENARD ; J. TRAN VAN NHIEU ; DEVEAUX V. ; L. LI ; SERRIERE-LANNEAU V. ; LEDENT C. ; A. MALLAT ; S. LOTERSZTAJN Année de publication : 2006 Article en page(s) : 683-685 Langues : Français (fre) Mots-clés : Thésaurus TOXIBASE
FOIE ; FIBROSE ; CANNABINOIDES ; RECEPTEUR ; PATHOLOGIE ORGANIQUE ; TRAITEMENT
Discipline : PAT Pathologie organique / Organic pathology Résumé : La mortalité par cirrhose représente encore aujourd’hui un problème de santé publique (environ 14 000 décès annuels en France à l’heure actuelle). La cirrhose est secondaire à l’accumulation progressive d’une fibrose dans le foie en réponse à une agression chronique, principalement d’origine alcoolique, virale (virus de l’hépatite B ou C), ou métabolique (stéato-hépatite non alcoolique). Réduire ou supprimer l’accumulation de la fibrose représente donc un objectif important de la prise en charge des maladies chroniques du foie. On ne dispose cependant pas, à ce jour, de molécule dont l’effet antifibrosant ait été démontré chez l’homme. Nous avons récemment démontré que l’utilisation de molécules ciblant le système cannabinoïde pourrait représenter une nouvelle approche pour le traitement de la fibrose hépatique. [Extrait] Domaine : Drogues illicites / Illicit drugs Refs biblio. : 10 Affiliation : Inserm U581, Hôp. H. Mondor, Créteil
Centre Emetteur : 13 OFDT Cote : A03127 Lien : http://id.erudit.org/iderudit/013769ar Permalink :
in Médecine/Sciences > Vol.22, n°8-9 (Août-Septembre 2006) . - 683-685[article]Antifibrogenic role of the cannabinoid receptor CB2 in the liver / B. JULIEN
Titre : Antifibrogenic role of the cannabinoid receptor CB2 in the liver Titre traduit : (Le rôle antifibrinogène du récepteur cannabinoïde CB2 dans le foie.) Type de document : Périodique Auteurs : B. JULIEN ; P. GRENARD ; F. TEIXEIRA-CLERC ; J. TRAN VAN NHIEU ; L. LI ; KARSAK M. ; A. ZIMMER ; A. MALLAT ; S. LOTERSZTAJN Année de publication : 2005 Importance : 742-755 Note générale : Gastroenterology, 2005, 128, (3), 742-755 Langues : Anglais (eng) Mots-clés : Thésaurus TOXIBASE
CANNABIS ; FIBROSE ; RECEPTEUR ; CANNABINOIDES ; FOIE ; IMMUNOLOGIE ; CIRRHOSE ; HISTOLOGIE ; BIOLOGIE
BACKGROUND & AIMS: Hepatic myofibroblasts are central for the development of liver fibrosis associated with chronic liver diseases, and blocking their accumulation may prevent fibrogenesis. Cannabinoids are the active components of marijuana and act via 2 G-protein-coupled receptors, CB1 and CB2. Here, we investigated whether liver fibrogenic cells are a target of cannabinoids. METHODS: CB2 receptors were characterized in biopsy specimens of normal human liver and active cirrhosis by immunohistochemistry, and in cultures of hepatic stellate cells and hepatic myofibroblasts by reverse-transcription polymerase chain reaction (RT-PCR), immunocytochemistry, and GTP[gamma]S assays. Functional studies were performed in cultured hepatic myofibroblasts and activated hepatic stellate cells. Carbon tetrachloride-induced liver fibrosis was studied in mice invalidated for CB2 receptors. RESULTS: In liver biopsy specimens from patients with active cirrhosis of various etiologies, CB2 receptors were expressed in nonparenchymal cells located within and at the edge of fibrous septa in smooth muscle alpha-actin-positive cells. In contrast, CB2 receptors were not detected in normal human liver. CB2 receptors were also detected in cultured hepatic myofibroblasts and in activated hepatic stellate cells. Their activation triggered potent antifibrogenic effects, namely, growth inhibition and apoptosis. Growth inhibition involved cyclooxygenase-2, and apoptosis resulted from oxidative stress. Finally, mice invalidated for CB2 receptors developed enhanced liver fibrosis following chronic carbon tetrachloride treatment as compared with wild-type mice. CONCLUSIONS: These data constitute the first demonstration that CB2 receptors are highly up-regulated in the cirrhotic liver, predominantly in hepatic fibrogenic cells. Moreover, this study also highlights the antifibrogenic role of CB2 receptors during chronic liver injury. (Author' s abstract)
Domaine : Drogues illicites / Illicit drugs Refs biblio. : 52 Affiliation : INSERM U581, 94010 Créteil
Centre Emetteur : 13 OFDT Cote : A03055 Permalink : Case management as a therapeutic enhancement: impact on post-treatment criminality / H. A. SIEGAL
Titre : Case management as a therapeutic enhancement: impact on post-treatment criminality Titre traduit : (Comment le suivi individualisé des patients renforce la démarche thérapeutique : son impact sur la criminalité post traitement.) Type de document : Périodique Auteurs : H. A. SIEGAL ; L. LI ; R. C. RAPP Année de publication : 2002 Importance : 37-46 Présentation : tabl. Note générale : Journal of Addictive Diseases, 2002, 21, (4), 37-46 Langues : Anglais (eng) Mots-clés : Thésaurus TOXIBASE
POST CURE ; TRAITEMENT ; RETENTION ; ACCOMPAGNEMENT ; EFFICACITE ; CRIMINALITE
Discipline : TRA Traitement et prise en charge / Treatment and care Résumé :
Using a sample of 453 veterans who received substance abuse treatment and were randomly assigned to case management and non-case management, this study examined both proximal (aftercare participation) and distal (severity of legal problems) measures of treatment outcomes. Multivariate analyses reveal that case-managed subjects stay longer in aftercare services than non-case managed clients. The longer post-treatment aftercare was related to better outcomes in criminality. The length of aftercare participation was also significantly associated with employment and readiness for treatment. (Author' s abstract)
Note de contenu : tabl. Domaine : Drogues illicites / Illicit drugs Refs biblio. : 30 Affiliation : Ctr Interventions, Treatment and Addict. Res., Wright State Univ. Sch. Med., 216 Med. Sci. Bild., Dayton, OH 45435. E-mai: harvey.siegalwright.edu
Etats-Unis. United States.
Numéro Toxibase : 206518 Centre Emetteur : 02 Coordonnateur Permalink : Causes of death up to 10 years after admissions to hospitals for self-inflicted, drug-related or alcohol-related, or violent injury during adolescence: a retrospective, nationwide, cohort study / A. HERBERT ; R. GILBERT ; D. COTTRELL ; L. LI in Lancet (The), Vol.390, n°10094 (August 5, 2017)
Titre : Causes of death up to 10 years after admissions to hospitals for self-inflicted, drug-related or alcohol-related, or violent injury during adolescence: a retrospective, nationwide, cohort study Type de document : Périodique Auteurs : A. HERBERT ; R. GILBERT ; D. COTTRELL ; L. LI Année de publication : 2017 Article en page(s) : 577-587 Langues : Anglais (eng) Mots-clés : Thésaurus Géographique
ALCOOL ; PRODUIT ILLICITE ; HOPITAL ; ADMISSION ; CAUSE DE DECES ; ETUDE RETROSPECTIVE ; COHORTE ; ACCIDENT ; ADOLESCENT ; VIOLENCE ; SUICIDE ; EPIDEMIOLOGIE ; HOMICIDE
Discipline : EPI Epidémiologie / Epidemiology Résumé : Background: Emergency hospital admission with adversity-related injury (ie, self-inflicted, drug-related or alcohol-related, or violent injury) affects 4% of 10-19-year-olds. Their risk of death in the decade after hospital discharge is twice as high as that of adolescents admitted to hospitals for accident-related injury. We established how cause of death varied between these groups.
Methods: We did a retrospective, nationwide, cohort study comparing risks of death in five causal groups (suicide, drug-related or alcohol-related, homicide, accidental, and other causes of death) up to 10 years after hospital discharge following adversity-related (self-inflicted, drug-related or alcohol-related, or violent injury) or accident-related (for which there was no recorded adversity) injury. We included adolescents (aged 10-19 years) who were admitted as an emergency for adversity-related or accident-related injury between April 1, 1997, and March 31, 2012. We excluded adolescents who did not have their sex recorded, died during the index admission, had no valid discharge date, or were admitted with injury related to neither adversity nor accidents. We identified admissions for adversity-related or accident-related injury to the National Health Service in England with the International Classification of Diseases-10 codes in Hospital Episode Statistics data, linked to the Office for National Statistics mortality data for England, to establish cause-specific risks of death between the first day and 10 years after discharge, and to compare risks between adversity-related and accident-related index injury after adjustment for age group, socioeconomic status, and chronic conditions.
Findings: We identified 1 080 368 adolescents (388 937 [36.0%] girls, 690 546 [63.9%] boys, and 885 [0.1%] adolescents who did not have their sex recorded). Of these adolescents, we excluded 40 549 (10.4%) girls, 56 107 (8.1%) boys, and all 885 without their sex recorded. Of the 333 009 (30.8%) adolescents admitted with adversity-related injury (181 926 [54.6%] girls and 151 083 [45.4%] boys) and 649 818 (60.2%) admitted with accident-related injury (166 462 [25.6%] girls and 483 356 [74.4%] boys), 4782 (0.5%) died in the 10 years after discharge (1312 [27.4%] girls and 3470 [72.6%] boys). Adolescents discharged after adversity-related injury had higher risks of suicide (adjusted subhazard ratio 4.54 [95% CI 3.25-6.36] for girls, and 3.15 [2.73-3.63] for boys) and of drug-related or alcohol-related death (4.71 [3.28-6.76] for girls, and 3.53 [3.04-4.09] for boys) in the next decade than they did after accident-related injury. Although we included homicides in our estimates of 10-year risks of adversity-related deaths, we did not explicitly present these risks because of small numbers and risks of statistical disclosure. There was insufficient evidence that girls discharged after adversity-related injury had increased risks of accidental deaths compared with those discharged after accident-related injury (adjusted subhazard ratio 1.21 [95% CI 0.90-1.63]), but there was evidence that this risk was increased for boys (1.26 [1.09-1.47]). There was evidence of decreased risks of other causes of death in girls (0.64 [0.53-0.77]), but not in boys (0.99 [0.84-1.17]). Risks of suicide were increased following self-inflicted injury (adjusted subhazard ratio 5.11 [95% CI 3.61-7.23] for girls, and 6.20 [5.27-7.30] for boys), drug-related or alcohol-related injury (4.55 [3.23-6.39] for girls, and 4.51 [3.89-5.24] for boys), and violent injury in boys (1.43 [1.15-1.78]) versus accident-related injury. However, the increased risk of suicide in girls following violent injury versus accident-related injury was not significantly increased (adjusted subhazard ratio 1.48 [95% CI 0.73-2.98]). Following each type of index injury, risks of suicide and risks of drug-related or alcohol-related death were increased by similar magnitudes.
Interpretation: Risks of suicide were significantly increased after all types of adversity-related injury except for girls who had violent injury. Risks of drug-related or alcohol-related death increased by a similar magnitude. Current practice to reduce risks of harm after self-inflicted injury should be extended to drug-related or alcohol-related and violent injury in adolescence. Prevention should address the substantial risks of drug-related or alcohol-related death alongside risks of suicide.
Funding: UK Department of Health.
Domaine : Alcool / Alcohol ; Drogues illicites / Illicit drugs Refs biblio. : 32 Affiliation : Population, Policy and Practice Programme, UCL Great Ormond Street Institute of Child Health, University College London, London, UK Permalink :
in Lancet (The) > Vol.390, n°10094 (August 5, 2017) . - 577-587[article]CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis / F. TEIXEIRA-CLERCPermalinkClient and program factors associated with dropout from court mandated drug treatment / E. EVANS in Evaluation and Program Planning, Vol.32, n°3 (August 2009)PermalinkEffectiveness of motivational interviewing to reduce illicit drug use in adolescents: a systematic review and meta-analysis / L. LI ; S. ZHU ; N. TSE ; S. TSE ; P. WONG in Addiction, Vol.111, n°5 (May 2016)PermalinkFatal methadone poisoning in children: Maryland 1992-1996 / L. LIPermalinkMeasuring readiness for change among crack cocaine users : a descriptive analysis / H. A. SIEGALPermalinkPrevalence and risk factors of illicit drug use by people with disabilities / D. MOOREPermalinkRespondent-driven sampling to recruit young adult non-medical users of pharmaceutical opioids: Problems and solutions / R. DANIULAITYTE ; R. FALCK ; L. LI ; R. W. NAHHAS ; R. G. CARLSON in Drug and Alcohol Dependence, Vol.121, n°1-2 (February 2012)PermalinkThe role of case management in retaining clients in substance abuse treatment : an exploratory analysis / H. A. SIEGALPermalink