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S. M. HUSBAND ; R. A. GLENNON ; GORGERAT S. ; GOUGH R. ; TYACKE R. ; J. CROSBY ; D. J. NUTT ; J. W. LEWIS ; A. L. HUDSON | 2001A series of beta-carbolines were prepared and their affinities for imidazoline (i1, and i2) sites evaluated. Selected compounds were also examined at x2-adrenoceptors. Some of the beta-carbolines were found to bind with high affinity to i2-sites[...]Article : Périodique
H. J. AUBIN ; J. REIMER ; D. J. NUTT ; A. BLADSTROM ; L. TORUP ; C. FRANÇOIS ; J. CHICK |Nalmefene is the first drug approved for reduction of alcohol consumption. The aim of this study was to evaluate the clinical relevance of treatment with nalmefene in alcohol-dependent patients with a high drinking risk level from two randomised[...]Article : Périodique
J. REHM ; S. MARMET ; P. ANDERSON ; A. GUAL ; L. KRAUS ; D. J. NUTT ; R. ROOM ; A. V. SAMOKHVALOV ; E. SCAFATO ; M. TRAPENCIERIS ; R. W. WIERS ; G. GMEL |Aims: The aim of the study was to explore whether the concept of heavy substance use over time can be used as definition of substance use disorder. Methods: Narrative review. Results: Heavy use over time clearly underlies the neurobiological[...]Article : Périodique
Proper assessment of the harms caused by the misuse of drugs can inform policy makers in health, policing, and social care. We aimed to apply multicriteria decision analysis (MCDA) modelling to a range of drug harms in the UK. Members of the Ind[...]Article : Périodique
Many psychoactive drugs are used recreationally, particularly by young people. This use and its perceived dangers have led to many different classes of drugs being banned under national laws and international conventions. Indeed, the possession [...]Article : Périodique
A web-based survey was used to consult the opinions of experienced drug users on matters related to drug harms. We identified a rare sample of 93 drug users with personal experience with 11 different illicit drugs that are widely used in the UK.[...]Article : Périodique
The recreational use of gamma hydroxy butyrate (GHB) has gained popularity over the last decade. GHB was initially sold as a safe body building and fat burning compound. It is now also widely abused by body builders and young ravers. GHB attract[...]Article : Périodique
This Royal Society Discussion Meeting, held on 25–26 February 2008, was intended to mark the enormous scientific progress that has been made in this field in the last decade or so, advances that can be measured from the time of a Frontiers Meeti[...]Article : Périodique
Article : Périodique
In this paper we discuss the relative physical, psychological and social harms of the two most frequently used intoxicant drugs in the UK, namely cannabis and alcohol. Over the past 40 years, the use of both drugs has risen significantly with di[...]Article : Périodique
C. B. McNABB ; B. R. RUSSELL ; D. CAPRIOLI ; D. J. NUTT ; S. GIBBONS ; J. W. DALLEY |A recent and dramatic increase in the emergence of novel psychoactive substances ('legal highs') has left many governments unable to provide a timely response to an increasing number of potentially harmful drugs now available to the public. In r[...]Périodique
F. D. LAW ; J. E. BAILEY ; D. S. ALLEN ; MELICHAR J. K. ; J. S. MYLES ; M. C. MITCHESON ; J. W. LEWIS ; D. J. NUTT | 1997FRANÇAIS : Treize hommes, d'âge moyen de 30 ans, répondant aux critères de dépendance aux opioïdes du DSM-III-R et recevant des doses quotidiennes de méthadone de 20 à 30 mg, ont été traités pendant 3 jours par 4 mg de buprénorphine sublinguale[...]Article : Périodique
C. CASAJUANA KOGEL ; M. M. BALCELLS-OLIVERO ; H. LOPEZ-PELAYO ; L. MIQUEL ; L. TEIXIDO ; J. COLOM ; D. J. NUTT ; J. REHM ; A. GUAL |Objective: Reliable data on cannabis quantities is required to improve assessment of cannabis consumption for epidemiological analysis and clinical assessment, consequently a Standard Joint Unit (SJU) based on quantity of 9-Tetrahydrocannabinol [...]Périodique
MELICHAR J. K. ; J. S. MYLES ; EAP C. B. ; D. J. NUTT | 2003ENGLISH : Substitute methadone prescribing is one of the main modes of treatment for opiate dependence. This study examined the relationship between methadone dose (measured by daily dose and methadone's active (R)- enantiomer blood levels) an[...]Bulletin : Périodique
Philosophical Transactions of the Royal Society B, Vol.363, n°1507 - October 2008 - Discussion meeting issue: The neurobiology of addiction
T. W. ROBBINS, Editeur scientifique ; B. J. EVERITT, Editeur scientifique ; D. J. NUTT, Editeur scientifique | 2008
