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Article : Périodique
Context: Rapid opioid detoxification with opioid antagonist induction using general anesthesia has emerged as an expensive, potentially dangerous, unproven approach to treat opioid dependence. Objective: To determine how anesthesia-assisted de[...]
Article : Périodique
M. HANEY ; E. W. GUNDERSON ; H. JIANG ; E. D. COLLINS ; R. W. FOLTIN |BACKGROUND. Rates of relapse among cocaine-dependent patients are high, and new treatment approaches are needed. Clinical data demonstrate that a cocaine vaccine (TA-CD) produces selective anticocaine antibodies, yet the impact of these antibodi[...]
Périodique
C. L. HART ; A. S. WARD ; E. D. COLLINS ; M. HANEY ; R. W. FOLTIN | 2004ENGLISH : Data from research with laboratory animals indicate that cocaine self-administration can be reduced by A-aminobutyric acid (GABA) agonists. Yet, the effectiveness of GABA agonists to decrease human cocaine self-administration has not[...]
Article : Périodique
B. FAVRAT ; J. BESSON ; M. M. MILLER ; E. D. COLLINS ; H. D. KLEBER ; R. A. WHITTINGTON ; CONTRERAS J. A. ; C. J. DE JONG ; P. G. O'CONNOR |Dr Collins and colleagues studied anesthesia-assisted vs buprenorphine- or clonidine-assisted heroin detoxification and naltrexone induction. The article and the accompanying editorial by Dr OConnor showed that detoxification is not in itself a [...]
Article : Périodique
Several sources indicate that intravenously administered buprenorphine may have significant abuse liability in humans. The present study evaluated the reinforcing effects of intravenously administered buprenorphine (0, 2, and 8 mg) in detoxified[...]
Article : Périodique
Buprenorphine is a partial μ-opioid agonist and κ-opioid antagonist currently under development as a maintenance medication for heroin dependence. Because of concerns about illicit diversion of buprenorphine, a combination tablet containing bupr[...]
Périodique
E. D. COLLINS ; STRELTZER J. | 2003
Article : Périodique
E. D. COLLINS ; T. HORTON ; K. REINKE ; L. AMASS ; E. V. NUNES |For opioid-dependent patients, the need for detoxification has been a barrier to entry into long-term residential treatment. This report describes a retrospective observational cohort study with the first 38 opioid-dependent patients entering Fi[...]
