Historique
Article de Périodique
Multi-analytical identification of the synthetic opioids cychlorphine and methiodone (IC-26) in drug seizures: first detection in Europe (2026)
Auteur(s) :
DUGUES, P. ;
ROBIN, T. ;
BELLOUARD, M. ;
CHENORHOKIAN, S. ;
TRIGUEL, M. ;
PFAU, G. ;
FENG, C. ;
CHERKI, S. ;
HERBETTE, G. ;
ALVAREZ, J. C. ;
LARABI, I. A.
Année
2026
Page(s) :
doi: 10.1515/cclm-2025-1428
Langue(s) :
Anglais
Refs biblio. :
44
Domaine :
Drogues illicites
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus géographique
FRANCE
;
EUROPE
Thésaurus mots-clés
OPIOIDES
;
DROGUES DE SYNTHESE
;
PHENOMENE EMERGENT
;
SAISIE
;
SURVEILLANCE EPIDEMIOLOGIQUE
;
ANALYSE CHIMIQUE
;
METHODE
;
MESURES QUALITATIVES
;
MESURES QUANTITATIVES
;
DEPISTAGE
;
PHARMACOLOGIE
;
CHIMIE
;
TOXICOLOGIE
Résumé :
OBJECTIVES: The rapid emergence of highly potent synthetic opioids represents a growing challenge for forensic and clinical laboratories.
METHODS: We report the first identification in Europe of methiodone (IC-26) and the first detection in France of cychlorphine in drug samples collected by a drug-checking service in Paris.
RESULTS: Preliminary screening by liquid chromatography with diode-array detection (LC-DAD) and gas chromatography coupled with mass spectrometry (GC-MS) revealed unknown peaks due to the lack of corresponding spectra in available spectral librairies. High-resolution mass spectrometry (LC-HRMS) provided accurate mass measurements consistent with the cychlorphine and Methiodone formulas. Structural confirmation was obtained by 1D/2D nuclear magnetic resonance (NMR) spectroscopy. Targeted LC-MS/MS quantified 5% cychlorphine and 2% methiodone, with no other psychoactive compounds detected.
CONCLUSIONS: These results highlight the limitations of library-based screening and the value of multi-platform strategies integrating LC-HRMS, LC-MS/MS, and NMR for the early detection of emerging drugs. [Author's abstract]
METHODS: We report the first identification in Europe of methiodone (IC-26) and the first detection in France of cychlorphine in drug samples collected by a drug-checking service in Paris.
RESULTS: Preliminary screening by liquid chromatography with diode-array detection (LC-DAD) and gas chromatography coupled with mass spectrometry (GC-MS) revealed unknown peaks due to the lack of corresponding spectra in available spectral librairies. High-resolution mass spectrometry (LC-HRMS) provided accurate mass measurements consistent with the cychlorphine and Methiodone formulas. Structural confirmation was obtained by 1D/2D nuclear magnetic resonance (NMR) spectroscopy. Targeted LC-MS/MS quantified 5% cychlorphine and 2% methiodone, with no other psychoactive compounds detected.
CONCLUSIONS: These results highlight the limitations of library-based screening and the value of multi-platform strategies integrating LC-HRMS, LC-MS/MS, and NMR for the early detection of emerging drugs. [Author's abstract]
Affiliation :
Pharmacology and Toxicology Laboratory, CHU Raymond Poincaré (AP-HP), MONITOR Platform (Carnot-APHP), UVSQ-Paris Saclay University, Inserm U1018, CESP Center for Research in Epidemiology and Population Health, Team MOODS, Garches, France
Analyse Ton Prod-IDF, Paris, France
National Identification System of Toxics Ad Substances (SINTES), French Observatory of Drugs and Addictive Tendencies (OFDT), Paris, France
NMR Department, Institute of Chemistry of Natural Substances, CNRS UPR2301, Gif sur Yvette Cedex, France
Analyse Ton Prod-IDF, Paris, France
National Identification System of Toxics Ad Substances (SINTES), French Observatory of Drugs and Addictive Tendencies (OFDT), Paris, France
NMR Department, Institute of Chemistry of Natural Substances, CNRS UPR2301, Gif sur Yvette Cedex, France