Historique
Article de Périodique
Nitrous oxide abuse: Clinical outcomes, pharmacology, pharmacokinetics, toxicity and impact on metabolism (2023)
Auteur(s) :
GERNEZ, E. ;
LEE, G. R. ;
NIGUET, J. P. ;
ZERIMECH, F. ;
BENNIS, A. ;
GRZYCH, G.
Année
2023
Page(s) :
art. 962
Sous-type de document :
Revue de la littérature / Literature review
Langue(s) :
Anglais
Refs biblio. :
77
Domaine :
Autres substances / Other substances
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
PROTOXYDE D'AZOTE
;
PHARMACOLOGIE
;
PHARMACOCINETIQUE
;
TOXICITE
;
METABOLISME
;
USAGE RECREATIF
;
EFFET SECONDAIRE
;
SYMPTOME
;
NEUROBIOLOGIE
;
SYSTEME NERVEUX CENTRAL
;
SYSTEME NERVEUX PERIPHERIQUE
;
ANTALGIQUES
;
ANESTHESIE
;
ANTIDEPRESSEURS
;
MECANISME D'ACTION
;
ABUS
Résumé :
The recreational use of nitrous oxide (N2O), also called laughing gas, has increased significantly in recent years. In 2022, the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) recognized it as one of the most prevalent psychoactive substances used in Europe. Chronic nitrous oxide (N2O) exposure can lead to various clinical manifestations. The most frequent symptoms are neurological (sensitive or motor disorders), but there are also other manifestations like psychiatric manifestations or cardiovascular disorders (thrombosis events). N2O also affects various neurotransmitter systems, leading to its anesthetic, analgesic, anxiolytic and antidepressant properties. N2O is very challenging to measure in biological matrices. Thus, in cases of N2O intoxication, indirect biomarkers such as vitamin B12, plasma homocysteine and plasma MMA should be explored for diagnosis and assessment. Others markers, like oxidative stress markers, could be promising but need to be further investigated. [Author's abstract]
Affiliation :
CHU de Lille, Centre de Biologie Pathologie Génétique, Lille, France
Mater Misericordiae University Hospital, Dublin, Ireland
Service de Neurologie, Hôpital Saint Vincent de Paul-GHICL, Lille, France
Assistance Publique-Hôpitaux de Paris, Service de Neurologie, Groupe Hospitalier Universitaire Paris Sud, Hôpital Bicêtre, Le Kremlin-Bicêtre, France
Mater Misericordiae University Hospital, Dublin, Ireland
Service de Neurologie, Hôpital Saint Vincent de Paul-GHICL, Lille, France
Assistance Publique-Hôpitaux de Paris, Service de Neurologie, Groupe Hospitalier Universitaire Paris Sud, Hôpital Bicêtre, Le Kremlin-Bicêtre, France