Historique
Article de Périodique
Disulfiram for the treatment of cocaine dependence (Review) (2024)
Auteur(s) :
TRACCIS, F. ;
MINOZZI, S. ;
TROGU, E. ;
VACCA, R. ;
VECCHI, S. ;
PANI, P. P. ;
AGABIO, R.
Année
2024
Page(s) :
art. CD007024
Sous-type de document :
Revue de la littérature / Literature review
Langue(s) :
Anglais
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
COCAINE
;
PHARMACOTHERAPIE
;
TRAITEMENT
;
EFFICACITE
;
ANTABUSE
;
EVALUATION
;
DEPENDANCE
;
NALTREXONE
;
COMPARAISON
;
PLACEBO
;
ABSTINENCE
Résumé :
Key messages :
- In people with cocaine dependence, disulfiram compared to placebo may increase the number of people who are abstinent at the end of treatment, but may have little or no effect on the frequency and amount of cocaine use and on the number of people who have achieved and maintained abstinence for at least three weeks at the end of treatment. We are unsure if disulfiram has any unwanted effects in people with cocaine dependence.
- In people with cocaine dependence, disulfiram compared to naltrexone may reduce the frequency of cocaine use but may have little or no effect on the amount of cocaine use.
- Of the 13 studies included in our review, 11 took place in the USA. Furthermore, most people included in the studies were men. Our results may not be applicable in other contexts because the effects of treatment could be strongly influenced by social environment, ethnicity, and sex.
- In people with cocaine dependence, disulfiram compared to placebo may increase the number of people who are abstinent at the end of treatment, but may have little or no effect on the frequency and amount of cocaine use and on the number of people who have achieved and maintained abstinence for at least three weeks at the end of treatment. We are unsure if disulfiram has any unwanted effects in people with cocaine dependence.
- In people with cocaine dependence, disulfiram compared to naltrexone may reduce the frequency of cocaine use but may have little or no effect on the amount of cocaine use.
- Of the 13 studies included in our review, 11 took place in the USA. Furthermore, most people included in the studies were men. Our results may not be applicable in other contexts because the effects of treatment could be strongly influenced by social environment, ethnicity, and sex.
Affiliation :
Department of Biomedical Sciences, Section of Neurosciences and Clinical Pharmacology, University of Cagliari, Cagliari, Italy