Historique
Article de Périodique
Case report of a fatal 3-hydroxyphencyclidine intoxication, including blood and hair results (2023)
Auteur(s) :
AMELINE, A. ;
BAUDRY, M. ;
GARNIER, D. ;
RAUL, J. S. ;
KINTZ, P.
Année
2023
Page(s) :
552-556
Sous-type de document :
Etude de cas / Case report
Langue(s) :
Anglais
Refs biblio. :
18
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus géographique
FRANCE
Thésaurus mots-clés
ETUDE DE CAS
;
INTOXICATION
;
PHENCYCLIDINE
;
DROGUES DE SYNTHESE
;
ANALYSE CHIMIQUE
;
MORT
;
SANG
;
PHANERES
Résumé :
3-hydroxyphencyclidine (3-OH-PCP) is a hydroxy derivative of phencyclidine, synthesized in 1978 to investigate the structure-activity relationship of phencyclidine derivates. In vitro studies have shown that 3-OH-PCP, like phencyclidine, acts on the NMDA receptor and has a higher affinity for this receptor than phencyclidine. The authors report the case of a 38-year-old man, known for drug addiction, found dead at home with two plastic bags of powders found near his body. Using LC-MS/MS, peripheral blood toxicological analysis revealed consumption of 3-OH-PCP with a concentration of 3-OH-PCP at 524 ng/mL. Blood also tested positive for nordiazepam, methylphenidate, amisulpride, methadone and benzoylecgonine, all at concentrations near those observed after recreational abuse. The blood concentration of 3-OH-PCP is the highest ever reported in the literature. Hair testing also revealed 3-OH-PCP, at 174 pg/mg, which may correspond to a chronic consumption of this molecule. A NMR analysis of the two powders highlighted 3-OH-PCP and 5-Meo-DMT, estimated at 85.4% and 91.3% of purity, respectively, using the Electronic Reference To access in vivo Concentrations (ERETIC) method.
Affiliation :
Institut de médecine légale, Strasbourg, France.
Laboratoire de Conception et Application de Molécules Bioactives, UMR 7199, Illkirch-Graffenstaden, France
Plateforme d'Analyse Chimique de Strasbourg-Illkirch, Illkirch-Graffenstaden, France
X-Pertise Consulting, Mittelhausbergen, France
Laboratoire de Conception et Application de Molécules Bioactives, UMR 7199, Illkirch-Graffenstaden, France
Plateforme d'Analyse Chimique de Strasbourg-Illkirch, Illkirch-Graffenstaden, France
X-Pertise Consulting, Mittelhausbergen, France